A Novel In-Vivo Cell Tracking System Based on Combined XCT and FT

基于 XCT 和 FT 组合的新型体内细胞追踪系统

基本信息

批准号：
7595163
负责人：
WILLIAM C BARBER
金额：
$ 35.81万
依托单位：
DXRAY, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7595163
关键词：
Address Algorithms Animal Model Animals Area Arts Beds California Cardiology Caring Cells Clinical Collaborations Data Deposition Detection Development Disease Dose Dourine Drug Delivery Systems Ensure Evaluation Film Fluorescence Funding Goals Hour Image Imaging Device Imaging Phantoms Imaging technology Leadership Longitudinal Studies Magnetic Resonance Imaging Marketing Measurement Medical Imaging Methodology Methods Modality Monitor Mus Neurology Performance Phase Production Reading Recording of previous events Research Research Personnel Resolution Scanning Semiconductors Signal Transduction Site Small Business Innovation Research Grant Source Stem Cell Research Stem cells System Systems Integration Techniques Technology Testing Therapeutic Time Travel Tube United States National Institutes of Health Universities X-Ray Computed Tomography anticancer research base cellular development cost design design and construction detector experience imaging modality improved in vivo innovation interest molecular imaging new technology novel novel strategies oncology pre-clinical preclinical study programs prototype reconstruction red mercuric iodide research study response scale up technological innovation tomography tool trafficking

项目摘要

DESCRIPTION (provided by applicant): We propose to build the world's first combined x-ray computed tomography (XCT) and fluorescence tomography (FT) system. The construction of this system will create a new molecular imaging tool for researchers performing stem cell and cancer research. Stem cell research holds great promise for the development of cellular therapies for the treatment of disease and the development of cell tracking methods is therefore extremely significant. Several important scientific and technological innovations developed by our team of investigators at DxRay Inc. (Northridge, CA) and the University of California Irvine (UCI) allow the creation of a novel combined XCT and FT system. This project produces a unique dual-modality imaging methodology that combines functional and anatomical information and provides a new approach to molecular imaging. At the completion of the proposed project the combined XCT and FT system will add unique imaging capabilities to the animal imaging facilities at UCI. Furthermore, the innovative XCT technology developed by DxRay and the novel FT technology developed by UCI will be commercialized with support from Gamma Medica Ideas (Northridge, CA) who are very interested in this development and are providing a gantry for the combined system. Cellular therapeutics show great promise for the treatment of many diseases, but unfortunately few non-invasive techniques exist for tracking the cells after administration. The ability to non-invasively monitor cell trafficking in-vivo longitudinally is a pressing need for emerging cellular therapeutic strategies since this could be used to assess response. In-vivo tracking of cells has a broad range of potential applications in various diseases covering the fields of neurology, oncology, and cardiology. Therefore, to address the need for new multi-modality molecular imaging technologies, that are capable of the non-invasive in-vivo longitudinal imaging of mice for cell tracking, we propose to build the first of its kind combined XCT and FT system. The development of this very promising new technology, the first to combine FT with anatomical information from XCT in a relatively inexpensive and easy to use system, will create a powerful new tool for stem cell research and targeted drug delivery studies. We are developing novel in-vivo combined x-ray computed tomography (XCT) and fluorescence tomography (FT) system. This new technology will create a new type of dual-modality molecular imaging. This project will create new cell tracking capabilities and will benefit preclinical studies of cellular therapies.

描述（由申请人提供）：我们建议建立世界上第一个组合的X射线计算机断层扫描（XCT）和荧光断层扫描（FT）系统。该系统的构建将为进行干细胞和癌症研究的研究人员创建一个新的分子成像工具。因此，干细胞研究对疾病治疗的细胞疗法的发展具有很大的希望，因此，细胞跟踪方法的发展非常重要。 DXRAY Inc.（加利福尼亚州诺斯里奇）和加利福尼亚大学欧文分校（UCI）的研究人员团队开发了一些重要的科学和技术创新，允许创建一种新颖的XCT和FT系统。该项目产生了独特的双模式成像方法，该方法结合了功能和解剖信息，并提供了一种新的分子成像方法。拟议项目完成时，组合的XCT和FT系统将为UCI的动物成像设施添加独特的成像功能。此外，DXRAY开发的创新XCT技术以及UCI开发的新型FT技术将在Gamma Medica Ideas（CA Northridge，CA）的支持下进行商业化，他们对这一开发非常感兴趣，并为合并系统提供了龙门。细胞疗法对许多疾病的治疗表现出了很大的希望，但不幸的是，在给药后跟踪细胞的非侵入性技术很少。非侵入性监测细胞运输的能力在体内纵向上是对新兴的细胞治疗策略的紧迫需求，因为这可以用于评估反应。细胞的体内跟踪在涵盖神经病学，肿瘤学和心脏病学领域的各种疾病中具有广泛的潜在应用。因此，为了满足对新型多模式分子成像技术的需求，这些技术能够对小鼠进行细胞跟踪的非侵入性体内纵向成像，我们建议构建同类XCT和FT系统的第一个组合。这项非常有前途的新技术的开发是第一个将FT与XCT的解剖信息相结合的，将在相对便宜且易于使用的系统中创造出强大的新工具，用于干细胞研究和靶向药物递送研究。我们正在开发新型的体内X射线计算机断层扫描（XCT）和荧光断层扫描（FT）系统。这项新技术将创建一种新型的双模式分子成像。该项目将创建新的细胞跟踪功能，并有益于细胞疗法的临床前研究。