Photon Counting Detectors for Clinical k-edge CT

用于临床 k 边缘 CT 的光子计数探测器

• 批准号: 8180319
• 负责人: WILLIAM C BARBER
• 金额: $ 84.69万
• 依托单位: DXRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-10 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8180319
• 关键词: Abdomen; Accounting; Address; Agreement; Algorithms; Anodes; Attenuated; Calcified; Calcium; Ceramics; Clinical; Computer Simulation; Contrast Media; Coupled; Custom; Data; Detection; Development; Diagnosis; Dimensions; Discrimination; Dose; Elements; Encapsulated; Evaluation; Feedback; Fibrosis; Floods; Floor; Gadolinium; Generations; Goals; Grant; Histocompatibility Testing; Human; Image; Imaging Phantoms; Imaging Techniques; Iodine; Length; Manufacturer Name; Marketing; Measures; Mechanics; Methods; Mind; Modeling; Neck; Noise; Output; Patients; Performance; Phase; Photons; Physiologic pulse; Polychlorinated Biphenyls; Positioning Attribute; Power Sources; Printing; Production; Property; Public Health; Radiation; Reading; Resolution; Risk; Roentgen Rays; Rotation; Running; Sampling; Scanning; Semiconductors; Shapes; Side; Simulate; Skin; Slice; Speed; Staging; System; Technology; Testing; Thick; Time; Tissue Differentiation; Tissues; Translating; Tube; Weight; Work; X-Ray Computed Tomography; base; bone; cold temperature; commercialization; data modeling; design; detector; gadolinium oxide; imaging modality; improved; millisecond; next generation; novel; operation; physical property; product development; prototype; public health relevance; radiologist; reconstruction; research study; response; simulation; simulation software; soft tissue; statistics; success; tumor

DESCRIPTION (provided by applicant): This fast track grant titled, "Photon Counting Detectors for Clinical k-edge CT" will enable DxRay to bring to market a customer-driven improved version of our CdTe-based photon- counting x-ray computed tomography (CT) detector with energy discrimination. These detectors have enabled significant improvements in CT imaging such as reduced patient dose while maintaining excellent image quality, enhanced tissue contrast, and material decomposition capabilities (tissue type identification). The overall goal is to bring to the CT marketplace a photon-counting energy-dispersive x-ray detector with energy discrimination for use in human x-ray CT imaging. So far we have demonstrated a first generation fast photon- counting x-ray imaging array which has a higher maximum output count rate (by more than an order of magnitude) than all others, and the arrays have been used to generate the first patient images to date. This first-generation system is capable of counting at over 5 W 106 counts per second per mm2 (cps/mm2) and has performed clinical scans at up to 300 mA of tube current, demonstrating both reduced dose and improved image quality in neck and abdomen studies. Our x-ray imaging arrays are completely vertically integrated and are compatible with all the existing gantries and x-ray tubes being used clinically. With feedback from our customers we have determined that there are two more performance enhancements required from our detector for the full commercialization of our technology. In the first year we will produce a fully functioning prototype of the second- generation photon-counting CT detector and demonstrate its performance with all the features our customers require. In the second and third year of the project we will, with feedback from our customers, produce the first production runs of the final product, with sufficient numbers of detectors to provide samples to our customers for testing in their clinical systems. This will allow for patient studies to be performed in existing gantries. We expect large commercial success with this product. This is due to the significant improvements to and advantages over existing detectors that our technology provides together with the widespread and increasing use of CT. The x-ray exposure in CT scanning has been of major concern for radiologists and physicists as the number of CT examinations has increased. Therefore, a method which reduces the patient dose in CT examinations will have a significant impact on public health. Our product addresses the need to reduce dose in CT. At the same time, improved tissue differentiation and material-specific identification is needed for better diagnosis. Our product addresses these needs by improving image quality by making use of the energy information contained in the individually counted x-rays at high flux, information that is currently not obtainable with the non photon-counting x-ray imaging arrays currently in use in multi-slice CT systems. PUBLIC HEALTH RELEVANCE: The overall goal of this proposal is to develop a photon counting CT detector with energy binning and read-out that is capable of producing energy resolved CT scan which can deliver less radiation dose and differentiate between tissue types. Photon counting detectors with energy binning can improve CT performance by counting and binning each x-ray detected.

描述（由申请人提供）：这项标题为“临床K-EDGE CT的光子计数检测器”的快速拨款将使DXRAY能够通过能量歧视的基于CDTE的光子计算X射线计算机（CT）检测器来推销我们基于CDTE的光子计算X射线计算机（CT）检测器的改进版本。这些探测器已经在CT成像方面有了显着改善，例如减少患者剂量，同时保持出色的图像质量，增强的组织对比度和材料分解能力（组织类型识别）。总体目标是将带有能量歧视的光子计算能量分散X射线检测器带到CT市场，用于人X射线CT成像。到目前为止，我们已经证明了第一代快速X射线成像阵列的第一代快照阵列，该阵列的最大输出计数速率（超过一个数量级）比所有其他阵列都高，并且这些阵列已被用于生成迄今为止的第一个患者图像。该第一代系统的计数能够以超过5 W 106的计数计数每秒每秒5 W 106计（CPS/mm2），并且在高达300 mA的管电流时进行了临床扫描，既降低剂量和颈部和腹部研究的图像质量降低。 我们的X射线成像阵列是完全垂直集成的，并且与临床上使用的所有现有巨塔和X射线管兼容。 通过客户的反馈，我们确定我们的检测器需要另外两种绩效提高，以实现我们的技术的全面商业化。在第一年，我们将制作出第二代光子计数CT检测器的功能齐全的原型，并通过客户所需的所有功能来展示其性能。在项目的第二年和第三年中，我们将在客户的反馈下生产最终产品的第一个生产运行，并提供足够数量的探测器，以向我们的客户提供样品以在其临床系统中进行测试。这将使患者研究可以在现有的龙盘中进行。 我们预计该产品的商业成功很大。这是由于我们的技术与CT的广泛使用和越来越多的使用一起提供的现有探测器的显着改善和优势。 CT扫描中的X射线暴露是放射科医生和物理学家的主要关注点，因为CT检查的数量增加了。因此，一种减少CT检查中患者剂量的方法将对公共卫生产生重大影响。我们的产品解决了减少CT剂量的必要性。同时，需要改进的组织分化和特定于材料的鉴定才能更好地诊断。我们的产品通过利用在高通量下的单独计数X射线中包含的能量信息来满足这些需求，而当前正在使用中的非光子计算X射线成像阵列中，目前无法获得的信息，这些信息目前无法获得。 公共卫生相关性：该提案的总体目标是开发具有能量箱和读取的光子计数CT检测器，该检测器能够产生能量解决的CT扫描，从而可以提供较少的辐射剂量并区分组织类型。具有能量箱的光子计数检测器可以通过计数和固定每个检测到的X射线来改善CT性能。