University of Wisconsin Transplant Reseach Training Program

威斯康星大学移植研究培训计划

• 批准号: 9925721
• 负责人: Dixon B Kaufman
• 金额: $ 27.7万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925721
• 关键词: Training Programs; Transplantation; Universities; Wisconsin

PROJECT SUMMARY The UW Transplant Research Training Program represents an essential funding mechanism for post- doctoral trainees and residents at our own institution and nationwide. The overall goal of the “UW Transplant Research Training Program” is to provide postdoctoral trainees who are strongly motivated toward a career in transplant related research, with a two-year, comprehensive, hypothesis-based research experience. Trainees will be exposed to a curriculum including principles of clinical trials, research design, management, ethics and data analysis. The training program will foster the development of knowledge, skills, professional attitudes, and experience required for successful academic careers. The program will maintain two trainees per year for a two-year training experience (accepting two new trainees each year). Our trainer pool includes a total of 12 faculty, representing six departments, including Cell and Regenerative Medicine, Medical Microbiology and Immunology, Medicine, Pathology and Laboratory Medicine, Pediatrics, and Surgery. Trainers have been selected based on extramural research support, prior mentoring experience, relevance of research goals to the training program, and already existing collaborations in the pursuit of translational research. Collectively, they have mentored over 115 post-doctoral trainees over the past 10 years including both MDs and PhDs. The specific objectives of this program are: (A) to provide training in the conduct of basic, translational and clinical transplant research focused on improving human health through participation in an individual and tailored didactic and mentoring program, and (B) to develop MD and PhD post-doctoral trainees as skilled team-oriented scientists with an emphasis on transplant research. The three areas of focus chosen for the program encompass the major research initiatives in transplant research at University of Wisconsin: i.) Immunobiology/ Immune Regulation, ii) Cellular Therapies/Regenerative Medicine, and iii) Translational research via large animal models. The strengths of the program include the breadth of funded research covering basic cellular in vitro projects, murine models, primates and human studies; an experienced trainer pool; collaboration with the UW Institute for Clinical and Translational Research (ICTR) funded by a CTSA; and a training model that encourages interactions and cross-training between clinicians and scientists. Additionally this program boasts individualized training plans, extensive institutional resources to enhance training, an experienced administrative infrastructure to assist with management of the program, a plan to promote diversity by recruiting and retaining both women and minorities, and a comprehensive plan for training in the responsible conduct of research. The administrative structure includes an Executive Committee, an External Advisory Board, a Diversity Advisory Committee, as well as program support and coordination utilizing an existing training grant program administrator within the Department of Surgery.

项目概要 华盛顿大学移植研究培训计划代表了移植后的重要资助机制。 我们自己的机构和全国范围内的博士生和住院医生“华盛顿大学移植”的总体目标。 “研究培训计划”旨在为有强烈职业动机的博士后培训生提供 移植相关研究，具有两年全面、基于假设的研究经验。 将接触到包括临床试验原理、研究设计、管理、伦理学和 培训计划将促进知识、技能、专业态度和能力的发展。 该计划每年将保留两名学员，为期一年。 两年的培训经验（每年接受两名新学员）。我们的培训师库共有 12 名。 教师，代表六个系，包括细胞与再生医学、医学微生物学和 免疫学、医学、病理学和实验医学、儿科和外科培训师。 根据校外研究支持、先前的指导经验、研究目标与研究目标的相关性进行选择 培训计划，以及在追求转化研究方面已经存在的合作。 过去 10 年来指导了超过 115 名博士后学员，其中包括医学博士和博士。 该计划的具体目标是： (A) 提供基本的、转化性的培训 临床移植研究的重点是通过参与个人和患者的参与来改善人类健康 量身定制的教学和指导计划，以及（B）将医学博士和博士后培训生培养为熟练的技术人员 以团队为导向的科学家，重点关注移植研究。选择的三个重点领域。 计划涵盖威斯康星大学移植研究的主要研究举措：i.) 免疫生物学/免疫调节，ii) 细胞疗法/再生医学，以及 iii) 转化 该计划的优势包括资助研究的广度。 涵盖基本细胞体外项目、小鼠模型、灵长类动物和人类研究； 池；与 CTSA 资助的威斯康星大学临床和转化研究所 (ICTR) 合作； 鼓励信徒和科学家之间互动和交叉培训的培训模式。 该项目拥有个性化的培训计划、丰富的机构资源来加强培训、 经验丰富的行政基础设施，以协助该计划的管理，该计划旨在促进 通过招募和留住妇女和少数族裔来实现多样性，以及全面的培训计划 负责开展研究的行政结构包括执行委员会、外部委员会。 咨询委员会、多元化咨询委员会以及计划支持和协调利用 外科部现有的培训补助金计划管理员。

项目成果

The "UW-LPHS Test": A New Test to Predict the Outcome of Renal Autotransplant for Loin Pain Hematuria Syndrome.

“UW-LPHS 测试”：一项预测腰痛血尿综合征自体肾移植结果的新测试。

• 发表时间: 2018-12
• 作者: Sollinger, Hans W;Al;Bath, Natalie;Redfield, Robert R
• 通讯作者: Redfield, Robert R

Renal autotransplantation results in pain resolution after left renal vein transposition.

自体肾移植可缓解左肾静脉转位后的疼痛。

• 发表时间: 2019
• 作者: Bath, Natalie M;Al;Williams, Daniel H;Sollinger, Hans W;Redfield 3rd, Robert R
• 通讯作者: Redfield 3rd, Robert R

Frequency of Preoperative Advance Care Planning for Older Adults Undergoing High-risk Surgery: A Secondary Analysis of a Randomized Clinical Trial.

接受高风险手术的老年人的术前预先护理计划的频率：随机临床试验的二次分析。

• 发表时间: 2021
• 影响因子: 16.9
• 作者: Kalbfell, Elle;Kata, Anna;Buffington, Anne S;Marka, Nicholas;Brasel, Karen J;Mosenthal, Anne C;Cooper, Zara;Finlayson, Emily;Schwarze, Margaret L
• 通讯作者: Schwarze, Margaret L

Impact of low-level pretransplant donor-specific antibodies on outcomes after kidney transplantation.

低水平移植前供者特异性抗体对肾移植后结果的影响。

• 发表时间: 2021
• 作者: Parajuli, Sandesh;Bath, Natalie M;Hidalgo, Luis;Leverson, Glen;Garg, Neetika;R Redfield 3rd, Robert;Mandelbrot, Didier A
• 通讯作者: Mandelbrot, Didier A

Novel Fusion Protein Targeting Mitochondrial DNA Improves Pancreatic Islet Functional Potency and Islet Transplantation Outcomes.

靶向线粒体 DNA 的新型融合蛋白可改善胰岛功能效力和胰岛移植结果。

• 发表时间: 2017-11
• 影响因子: 3.3
• 作者: Danobeitia, Juan S;Chlebeck, Peter J;Shokolenko, Inna;Ma, Xiaobo;Wilson, Glenn;Fernandez, Luis A
• 通讯作者: Fernandez, Luis A