Tomotherapy and Hematopoietic Stem Cells for Tolerance to Kidney Transplants

断层放射治疗和造血干细胞对肾移植的耐受性

• 批准号: 10518420
• 负责人: Dixon B Kaufman
• 金额: $ 57.85万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10518420
• 关键词: Allogenic; Allografting; Animals; Antithymoglobulin; Biological Assay; Bone Marrow; Bone Marrow Transplantation; CD14 gene; Cell surface; Cells; Chimerism; Clinical Research; Cryopreservation; Dendritic Cells; Development; Donor person; Engraftment; Environment; Frequencies; Goals; Hematopoietic; Hematopoietic stem cells; Immune; Immunologic Monitoring; Immunosuppression; In Vitro; Infusion procedures; Kidney; Kidney Transplantation; Knowledge; Living Donors; Macaca mulatta; Maintenance; Modeling; Myeloid-derived suppressor cells; Organ; Organ Transplantation; Peripheral; Population; Process; Protocols documentation; Rhesus; Role; Safety; T-Lymphocyte; Testing; Tomotherapy; Transplant Recipients; Transplantation; Transplantation Tolerance; Up-Regulation; base; conditioning; fitness; kidney allograft; lymphoid irradiation; monocyte; organ transplant recipient; peripheral blood; post-transplant; pre-clinical; preservation; programmed cell death protein 1; prospective; receptor; repository; success

项目成果

Impact of Human Mutant TGFβ1/Fc Protein on Memory and Regulatory T Cell Homeostasis Following Lymphodepletion in Nonhuman Primates.

人类突变体 TGFβ1/Fc 蛋白对非人灵长类淋巴清除后记忆和调节性 T 细胞稳态的影响。

• 发表时间: 2016-10
• 作者: Guo, H;Lu, L;Wang, R;Perez;Abdulkerim, H S;Zahorchak, A F;Sumpter, T L;Reimann, K A;Thomson, A W;Ezzelarab, M B
• 通讯作者: Ezzelarab, M B

In Vivo Mobilization and Functional Characterization of Nonhuman Primate Monocytic Myeloid-Derived Suppressor Cells.

非人灵长类单核细胞骨髓源性抑制细胞的体内动员和功能表征。

• 发表时间: 2016-02
• 作者: Zahorchak, A F;Ezzelarab, M B;Lu, L;Turnquist, H R;Thomson, A W
• 通讯作者: Thomson, A W

Helical tomotherapy-based total lymphoid irradiation: a more precise and less toxic radiation delivery system for consideration in composite tissue allotransplantation.

基于螺旋断层放疗的全淋巴照射：一种更精确、毒性更小的放射输送系统，用于复合组织同种异体移植。

• 发表时间: 2015-03
• 影响因子: 3.6
• 作者: Kempton, Steve J;Robertson, Frederick A;Bentz, Michael L;Kaufman, Dixon B
• 通讯作者: Kaufman, Dixon B

Patterns of Immune Regulation in Rhesus Macaque and Human Families.

恒河猴和人类家族的免疫调节模式。

• 发表时间: 2015-07
• 影响因子: 2.3
• 作者: Burlingham, William J;Jankowska;Kempton, Steve;Haynes, Lynn;Kaufman, Dixon B
• 通讯作者: Kaufman, Dixon B

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

对小鼠和非人类灵长类动物移植的同种异体胰岛的操作免疫耐受。

• 发表时间: 2019
• 影响因子: 8.2
• 作者: Abdulreda, Midhat H;Berman, Dora M;Shishido, Alexander;Martin, Christopher;Hossameldin, Maged;Tschiggfrie, Ashley;Hernandez, Luis F;Hernandez, Ana;Ricordi, Camillo;Parel, Jean;Jankowska;Burlingham, William J;Arrieta
• 通讯作者: Arrieta