CELLULAR MECHANISMS FOR SARCOPENIA IN THE ELDERLY

老年人肌肉减少症的细胞机制

基本信息

批准号：
7607846
负责人：
MARIE C GELATO
金额：
$ 3.14万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-23 至 2007-11-30
项目状态：
已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Loss of body protein occurs with advancing age with selective depletion of muscle tissue, is known as sarcopenia. Since the loss of lean body mass is primarily from muscle tissue, it has important implications for the maintenance of muscle strength and function. In addition to the serious consequences for muscle function, sarcopenia also reduces the reserve of amino acids available for mobilization in times of stress. Diminished reserve of amino acids in wasted patients during critical illness is a major determinant of outcome. Muscle protein undergoes continual synthesis and degradation. When the rates of protein synthesis and degradation are balanced, muscle protein mass is maintained, but if protein degradation exceeds synthesis, there will be a loss of muscle protein. At the tissue level, loss of muscle protein in the elderly has been associated with a reduction in the rate at which muscle protein is synthesized with no difference in muscle degradation between younger and older subjects. It is therefore important to consider the factors that control protein synthesis in muscle when seeking the mechanism of muscle wasting in the elderly.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。随着肌肉组织的选择性耗竭，身体蛋白质的丧失随着年龄的增长而发生，称为肌肉减少症。由于瘦体重的损失主要来自肌肉组织，因此对维持肌肉力量和功能具有重要意义。除了对肌肉功能的严重后果外，肌肉减少症还减少了在压力时期可动员的氨基酸储备。在危重疾病期间，浪费患者的氨基酸储备减少是预后的主要决定因素。肌肉蛋白经历持续的合成和降解。当蛋白质合成和降解的速率平衡时，保持肌肉蛋白质质量，但是如果蛋白质降解超过合成，则肌肉蛋白会损失。在组织水平上，老年人中肌肉蛋白的损失与肌肉蛋白合成的速率降低有关，而年轻受试者和老年受试者之间的肌肉降解没有差异。因此，重要的是要考虑在老年人中寻求肌肉浪费机制时控制肌肉中蛋白质合成的因素。