Effects of maternal obesity and gestational diabetes on offspring health

母亲肥胖和妊娠糖尿病对后代健康的影响

基本信息

批准号：
7617987
负责人：
Paula Catherine Chandler-Laney
金额：
$ 4.51万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-01 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7617987
关键词：
8 year old Adverse effects African African American American Area Attenuated Authorization documentation Body Composition Body fat Boxing Child Childhood Chronic Clinical Research Communities Comorbidity Diabetic intrauterine environment Diet Dietary intake Dyslipidemias Eating Enrollment Ensure Environment Epigenetic Process Exhibits Exposure to Family Fasting Fatty acid glycerol esters Female of child bearing age Genotype Gestational Diabetes Health High Density Lipoprotein Cholesterol High Prevalence Home environment Hormones Hour Hypertriglyceridemia Inpatients Insulin Insulin Resistance Intake Interleukin-6 LDL Cholesterol Lipoproteins Lipids Measures Metabolic Metabolic Diseases Mothers Nutritional Obesity Overweight Parents Physical activity Population Pregnancy Recruitment Activity Relative (related person)Reporting Research Risk Satiation Testing United States Visit Weight Woman blood glucose regulation blood lipid cytokine diabetes risk disorder risk environmental intervention feeding ghrelin glucagon-like peptide 1 glucose tolerance high risk in utero insulin secretion insulin sensitivity offspring prenatal exposure transmission process

项目摘要

DESCRIPTION (provided by applicant): Over half of all women of child-bearing age are overweight or obese, and maternal obesity increases the risk of developing gestational diabetes mellitus (GDM), which is found in 2-5% of pregnancies in the United States. Children born from pregnancies complicated by maternal obesity and/or GDM are at increased risk themselves for chronic obesity and metabolic health problems such as insulin resistance. African American (AA) children are at particular risk given the high prevalence of obesity among AA women (70% of AA women of child-bearing age are overweight or obese), and the comorbidity between obesity and GDM. The intrauterine environment provides a mechanism through which obesity and diabetes risk may be transmitted from mother to child. The proposed research aims to investigate the independent and interactive effects of maternal obesity and of GDM on the body composition and metabolic health of AA children. We hypothesize that children exposed to an obesogenic and/or diabetic intrauterine environment will have more body fat, greater insulin secretion and lower insulin sensitivity, dyslipidemia, increased cytokine levels, and reduced satiety hormone levels. We will recruit AA women for whom information is available regarding their glucose tolerance during pregnancy, and seek permission to enroll their 5-8 year-old children in our study. Children will be grouped according to their mothers' weight (obese vs. normal weight) and GDM (GDM or non-GDM) status during pregnancy. During an inpatient clinical research center visit to ensure controlled food intake conditions, children's body composition will be assessed by dual-energy x-ray absorptiometry (DXA), their blood lipid, cytokine, and satiety hormone profiles will be obtained, and their insulin sensitivity, secretion and clearance assessed via a mixed-meal tolerance test. In addition, we will measure children's physical activity via accelerometers, and their dietary intake via three 24-hour recalls, to determine whether any between group differences in these variables contribute to differences in body composition and metabolic health. By gaining an understanding of the independent and interactive effects of maternal obesity and of GDM on pediatric health, we can better identify the population at greatest risk for chronic health problems before they develop, and may be able to elucidate mechanisms to overcome the adverse effects of prenatal exposure to obesity and/or GDM. Relevance: Ultimately, this and subsequent related research will yield information regarding the manner in which obesity and diabetes risk are transmitted, and will identify nutritional and environmental interventions to inhibit the epigenetic transmission of obesity and metabolic disease.

描述（由申请人提供）：超过一半的育龄妇女超重或肥胖，孕产妇肥胖会增加患妊娠期糖尿病 (GDM) 的风险，在美国，2-5% 的孕妇患有妊娠期糖尿病 (GDM)。国家。患有母亲肥胖和/或 GDM 的妊娠所生的儿童本身患慢性肥胖和代谢健康问题（例如胰岛素抵抗）的风险增加。鉴于非裔美国人 (AA) 女性肥胖率较高（70% 的 AA 育龄女性超重或肥胖）以及肥胖与妊娠期糖尿病 (GDM) 的合并症，非裔美国人 (AA) 儿童面临的风险尤其高。子宫内环境提供了一种机制，肥胖和糖尿病风险可以通过该机制从母亲传播给孩子。拟议的研究旨在调查母亲肥胖和 GDM 对 AA 儿童的身体成分和代谢健康的独立和交互影响。我们假设，暴露于致肥胖和/或糖尿病宫内环境的儿童将有更多的体脂、更多的胰岛素分泌和更低的胰岛素敏感性、血脂异常、细胞因子水平增加和饱腹感激素水平降低。我们将招募 AA 女性，她们可以获得有关怀孕期间葡萄糖耐量的信息，并寻求许可将她们的 5-8 岁孩子纳入我们的研究。将根据母亲的体重（肥胖与正常体重）和怀孕期间的 GDM（GDM 或非 GDM）状态对儿童进行分组。在住院临床研究中心访问期间，为了确保控制食物摄入条件，将通过双能 X 射线吸收测定法 (DXA) 评估儿童的身体成分，获得他们的血脂、细胞因子和饱腹感激素概况，以及他们的胰岛素敏感性、分泌和清除通过混合膳食耐受性测试进行评估。此外，我们将通过加速度计测量儿童的身体活动，并通过 3 次 24 小时回忆来测量他们的饮食摄入量，以确定这些变量的组间差异是否会导致身体成分和代谢健康的差异。通过了解孕产妇肥胖和 GDM 对儿科健康的独立和交互影响，我们可以在慢性健康问题出现之前更好地识别出慢性健康问题风险最大的人群，并可能能够阐明克服孕产妇肥胖和 GDM 不利影响的机制。产前暴露于肥胖和/或 GDM。相关性：最终，这项研究和后续的相关研究将提供有关肥胖和糖尿病风险传播方式的信息，并将确定营养和环境干预措施，以抑制肥胖和代谢疾病的表观遗传传播。