The Snack Study

零食研究

基本信息

批准号：
8806863
负责人：
Paula Catherine Chandler-Laney
金额：
$ 6.93万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-04 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8806863
关键词：
Abdomen Adherence African American Award Behavioral Beverages Biogenesis Calories Child Consumption Data Development Diet Dietary Intervention Eating Economics Energy Intake Environment Evaluation Exposure to Fasting Fetal Growth Fetus Focus Groups Food Future Future Generations Glucose Glycemic Index Goals Growth Health Hour Individual Infant Insulin Intake Intervention Life Literature Low income Measures Metabolic Metabolism Methodology Modeling Mothers Nutritional Obesity Outcome Pathway interactions Pattern Perception Perinatal Exposure Phase Placenta Play Population Pregnancy Prevention Publishing Randomized Controlled Trials Regulation Relative (related person)Research Research Support Risk Risk Factors Role Sleep Target Populations Testing Third Pregnancy Trimester Time Weight Weight Gain Woman base behavior change behavior influence biobehavior experience fetal fetal programming follow-up food consumption glucose tolerance high risk improved infant outcome lifestyle intervention maternal diabetes neonate neurodevelopment next generation non-diabetic obesity risk offspring pregnant prevent programs public health relevance shift work social standard care transmission process trial design

项目摘要

DESCRIPTION (provided by applicant): Existing research supports a role for the intrauterine environment in modifying risk for obesity in offspring. Maternal obesity and relatively high glucose concentrations are two commonly cited predictors of obesity in the next generation, potentially via the delivery of excess fuel across the placenta to the developing fetus, which in turn, may program fetal metabolism in a manner that promotes excess weight gain in the future. Although a number of lifestyle interventions to improve maternal and infant outcomes have previously been attempted, results are often modest at best. Furthermore, few studies have proved to be efficacious among low income African American women who have high risk for the transmission of obesity to future generations. Research previously conducted by the PI (K01DK090126; DRC pilot award), has discovered that late-night consumption of high glycemic index (GI) foods is very prevalent in late pregnancy among African American women who are obese. Consistent with the existing literature describing adverse metabolic consequences of shift-work and late-night eating, this diurnal pattern of intake was associated with reduced glucose tolerance in the mothers, and a number of infant outcomes that are themselves associated with future obesity. The overall goal of this study is to follow-up this previous research by examining the feasibility of developing an intervention to reduce late-night intake of high-GI foods and beverages among obese African American women, in order to improve maternal glucose tolerance and reduce excess fetal growth in late gestation. This goal will be achieved with a two-phase study. First, focus groups will be conducted with pregnant African American women who are obese, in order to identify reasons for late-night consumption of high-GI foods, barriers against changing this behavior, and perceptions of an intervention to reduce late-night high-GI intake. Second, a randomized control trial (RCT) design will be used to examine the feasibility of conducting an intervention to reduce late-night high-GI consumption among obese women during the third trimester. The intervention will provide lower-GI alternatives to replace the high-GI foods and beverages that are typically consumed by the target population. Changes in free-living glycemic variability, glucose tolerance, and fetal abdominal growth, during the intervention will be measured and compared to those of women in a control (i.e. standard care) group. At the conclusion of this study, it is anticipated that suffiient preliminary data will have been obtained with which to inform a larger and more comprehensive RCT. Furthermore, this study will support the PI's transition to independence by providing an opportunity to experimentally examine the biobehavioral mechanisms underlying the development of obesity following intrauterine exposure to maternal obesity and/or high glucose concentrations.

描述（由申请人提供）：现有研究支持子宫内环境在改变后代肥胖风险方面的作用。母亲肥胖和相对较高的浓度是下一代肥胖的两个常见预测因素，可能是通过体内传递过量的燃料。尽管之前已经尝试过许多生活方式干预措施来改善母婴结局，但结果往往有限。此外，很少有研究证明对将肥胖遗传给后代的高风险的低收入非裔美国女性有效。PI 之前进行的研究（K01DK090126；刚果民主共和国试点奖）发现，这一点在深夜进行。在肥胖的非裔美国女性中，怀孕后期食用高血糖指数 (GI) 食物的情况非常普遍，这种每日摄入模式与描述轮班工作和深夜饮食的不良代谢后果的现有文献一致。与母亲的葡萄糖耐量降低有关，并且许多婴儿的结局本身与未来的肥胖有关。这项研究的总体目标是通过研究开发干预措施以减少晚期肥胖的可行性来跟进先前的研究。肥胖的非洲裔美国女性夜间摄入高升糖指数食物和饮料，以提高母亲的葡萄糖耐量并减少妊娠后期胎儿的过度生长。首先，将进行焦点小组研究。与肥胖的非裔美国孕妇进行调查，以确定深夜食用高血糖指数食物的原因、改变这种行为的障碍以及对减少深夜高血糖指数摄入的干预措施的看法其次，将使用随机对照试验（RCT）设计来检验可行性。进行一项干预措施，以减少肥胖妇女在妊娠晚期的深夜高升糖指数摄入量。该干预措施将提供低升糖指数替代品，以替代目标人群通常消耗的高升糖指数食物和饮料。活体血糖变异性、葡萄糖耐量和胎儿腹部将测量干预期间女性的生长情况，并将其与对照组（即标准护理）组的妇女进行比较。在本研究结束时，预计将获得足够的初步数据，为更多的人提供信息。此外，这项研究将通过提供一个机会来通过实验检查子宫内暴露于母亲肥胖和/或高葡萄糖浓度后导致肥胖的生物行为机制，从而支持 PI 向独立的过渡。