NexGen 7T MRI scanner for mesoscale brain imaging: Integration and Dissemination

用于中尺度脑成像的 NexGen 7T MRI 扫描仪：整合与传播

• 批准号: 10725586
• 负责人: Alexander Beckett
• 金额: $ 135.69万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10725586
• 关键词: 3-Dimensional; Acceleration; Alzheimer' s Disease; Area; BRAIN initiative; Brain; Brain imaging; COVID-19 pandemic; Cells; Collaborations; Communication; Data; Data Analyses; Development; Diffusion; Education and Outreach; Educational workshop; Engineering; Ensure; Epilepsy; Feedback; Fingerprint; Functional Magnetic Resonance Imaging; Funding; Germany; Goals; Head; Human; Human Resources; Image; Imaging Techniques; Infrastructure; Institution; International; Internet; Magnetic Resonance Imaging; Magnetism; Mental disorders; Neocortex; Neurons; Neurosciences; Neurosciences Research; Performance; Peripheral; Peripheral Nerve Stimulation; Persons; Physiologic pulse; Pilot Projects; RF coil; Reproducibility; Research; Research Personnel; Resolution; Resources; Scanning; Scientist; Signal Transduction; Speed; Structure; Synapses; System; Technology; Testing; Time; Training; Travel; United States National Institutes of Health; Work; base; brain circuitry; brain magnetic resonance imaging; brain research; computer infrastructure; connectome; data exchange; density; design; experimental study; imaging approach; improved; innovation; instrument; meetings; neocortical; nervous system disorder; neural circuit; neuroimaging; neuronal circuitry; next generation; novel; operation; outreach; prospective; recruit; symposium; temporal measurement; tool; transmission process

SUMMARY The "NexGen" 7 Tesla MRI scanner at UC Berkeley is a unique resource that we wish to make available for neuroscience collaborations across the globe. It was specifically designed for extremely high resolution structural and functional neuroimaging at the scale of cortical laminae and columnar neurocircuit organization ("meso-scale"). To achieve this, the NexGen scanner builds upon existing standard 7T scanners and integrates a number of technological advances, creating synergistic improvements and gains in speed, resolution and signal. Such advances include: currently the highest performance one-of-a-kind head-only magnetic gradient coil designed to safely create more signal at faster time scales (higher gradient amplitudes and slew rates without peripheral nerve stimulation; PNS), high-density receiver array coils (e.g. up to 128 channel receive array integrated into a 7T) that enable unprecedented spatial resolution and image-forming accelerations. As part of this collaborative endeavor, we will be creating novel advances in pulse sequences for novel neuroscientific applications imaging to take advantage of the scanner hardware’s higher performance. The scanner has been validated in reproducible mesoscale fMRI studies using GE-EPI and VASO fMRI at isotropic resolutions between 0.39 mm and 0.6 mm, that is a 4.6 to 23-fold higher volumetric resolution over typical 1 mm isotropic resolution in fMRI on conventional 7T scanners. The stronger gradients offer considerable improvements in diffusion imaging reaching higher b-values with shortened TEs. These hardware advances also enable larger areas of brain coverage, higher temporal resolutions and reduced distortions at mesoscale resolutions. Thus, with the NexGen 7T, meso-scale neuroscience experiments can be greatly expanded from traditional zoomed, small volume imaging approaches. Such a one-of-a-kind instrument has great potential to continue to advance the field and will be optimally used by a diverse group of neuroscientists and clinician scientists. Funding of the current U24 proposal would facilitate engineering and scientific personnel to support and maintain the use of the scanner; enables efficient data transfer and analysis, as well as the subject recruitment, user training and guidance of scientific collaborations nationally and internationally. While the main goal of this project is to provide an innovative resource for higher granularity in functional and structural human brain research, the research resource also holds potential for better understanding neurological diseases, such as Epilepsy, Alzheimer’s and mental disorders.

概括 加州大学伯克利分校的“ Nexgen” 7 Tesla MRI扫描仪是我们希望提供的独特资源 全球神经科学合作。它是专门为极高分辨率而设计的 皮质层层和柱状神经电路组织的结构和功能性神经影像学 （“中尺度”）。为了实现这一目标，Nexgen扫描仪建立在现有的标准7T扫描仪和 整合了许多技术进步，创造了协同的改进和速度提高， 分辨率和信号。这样的进步包括：目前表现最高 磁性梯度线圈旨在在更快的时间尺度上安全地创建更多信号（较高的梯度放大器 没有周围神经刺激的杀伤率； PNS），高密度接收器阵列线圈（例如，高达128 频道接收到集成到7T）的阵列，该数组可以实现前所未有的空间分辨率和图像形成 加速度。作为这项合作努力的一部分，我们将在脉冲序列中创造新的进步 用于新型神经科学应用成像，以利用扫描仪硬件的更高 表现。使用GE-EPI和 各向同性分辨率在0.39毫米至0.6毫米之间的血管FMRI，即体积高4.6至23倍 传统7T扫描仪上fMRI中典型1 mM各向同性分辨率的分辨率。较强的梯度 通过缩短TES，扩散成像达到更高的B值的扩散成像提供了可观的改进。这些 硬件进步还可以使大脑覆盖范围，更高的临时解决方案和减少 中尺度分辨率的扭曲。通过Nexgen 7T，中尺度的神经科学实验可以 从传统的缩放小型成像方法中大大扩展。这样的独一无二 乐器具有继续推进该领域的巨大潜力，并将被多样化的群体最佳使用 神经科学家和临床科学家。当前U24提案的资金将有助于工程 和科学人员支持和维持扫描仪的使用；启用有效的数据传输和 分析以及本国科学合作的主题招聘，用户培训和指导 和国际。该项目的主要目标是为更高的创新资源提供创新的资源 功能性和结构性人脑研究中的粒度，研究资源也有可能 更好地了解神经系统疾病，例如癫痫，阿尔茨海默氏症和精神疾病。