Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's disease

心脑 MRI 用于评估衰老和阿尔茨海默氏病的血流动力学耦合

• 批准号: 10571411
• 负责人: Kelly Brooke Jarvis
• 金额: $ 12.41万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571411
• 关键词: 3-Dimensional; 4D MRI; Abeta clearance; Acceleration; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Aorta; Blood; Blood Flow Velocity; Blood Pressure; Blood Vessels; Blood flow; Brain; Brain imaging; Buffers; Cardiovascular system; Caregivers; Cerebrovascular Disorders; Cerebrum; Chest; Clinical; Cognitive aging; Complex; Coupling; Data; Dedications; Dementia; Development; Elderly; Evaluation; Foundations; Future; Goals; Head and neck structure; Heart; Hypertension; Imaging Techniques; Impairment; Individual; Lead; Link; Magnetic Resonance Imaging; Maps; Measures; Methodology; Methods; Neurons; Pathology; Pattern; Physiologic pulse; Physiological; Pilot Projects; Postdoctoral Fellow; Production; Protocols documentation; Pulsatile Flow; Quality of life; Radiology Specialty; Research; Scanning; Structure; Techniques; Training; White Matter Hyperintensity; brain abnormalities; brain magnetic resonance imaging; cardiovascular imaging; cardiovascular risk factor; cerebral atrophy; cerebrovascular; dementia risk; design; diagnostic tool; doctoral student; hemodynamics; improved; innovation; insight; middle age; modifiable risk; neuroimaging; normal aging; novel; novel strategies; physical inactivity; prevent; programs; tool

Project Summary/Abstract Cardiovascular risk factors have been implicated in Alzheimer's disease and related dementias, however, mechanisms underlying heart-brain hemodynamic coupling are not well understood. Aortic stiffening has been associated with increased dementia risk. In addition to brain changes typically associated with aging, cerebrovascular disease and Alzheimer's disease also affect vascular function and neuronal structure. However, the heart and brain are not usually evaluated in the same MRI exam, rather, in separate scanning sessions with highly specialized protocols focused on either cardiovascular or brain imaging. Recently, our group and others have established advanced MRI techniques to capture measures such as cardio- and cerebrovascular hemodynamics and brain structure in the same MRI exam. Measuring aortic hemodynamics (e.g., pulse wave velocity), together with intracranial pulsatility and brain abnormalities associated with cerebrovascular disease and Alzheimer's disease, will provide critical insights concerning underlying hemodynamic mechanisms. The proposed research will use advanced MRI techniques for comprehensive analysis of heart-brain hemodynamic coupling. This project will leverage new developments in cardiovascular imaging, particularly using 4D flow MRI, that enable full characterization of complex 3D hemodynamics, such as blood flow velocity, reverse flow mapping and aortic pulse wave velocity. Methodological advances in highly accelerated 4D flow MRI enable integration of cardiovascular and intracranial 4D flow MRI with quantitative structural analysis of the brain in a single MRI exam. This combined cardio- and cerebrovascular 4D flow MRI with quantitative brain imaging (i.e. “heart-brain MRI”) will be used to analyze hemodynamic coupling in aging and Alzheimer's disease. The goal of this proposal is to use novel heart-brain MRI to systematically evaluate hemodynamic coupling relationships in normal aging, and hypertension, and apply this technique in a pilot study of Alzheimer's disease. In Aims 1 and 2, heart-brain MRI will be evaluated in healthy adults and those with hypertension at both midlife and later life, to determine relationships between heart-brain MRI measures in normal aging and how hypertension may exacerbate brain changes with aging. In Aim 3, heart-brain MRI will be applied in a pilot study of Alzheimer's disease to examine preliminary relationships and help plan future studies. This K01 will provided training in clinical and neuroimaging aspects of aging and Alzheimer's disease to further the objective of building an independent research program focused on heart-brain hemodynamic coupling in cognitive aging and dementia, including that caused by Alzheimer's disease.

项目摘要/摘要 然而，在阿尔茨海默氏病和相关痴呆症中隐含了心血管危险因素 心脏血液动力学耦合的基础机制尚不清楚。主动脉僵硬已经 与痴呆症风险增加有关。除了通常与衰老有关的大脑变化外， 脑血管疾病和阿尔茨海默氏病也会影响血管功能和神经元结构。然而， 通常在同一MRI检查中评估心脏和大脑 高度专业的方案侧重于心血管或脑成像。最近，我们的小组和其他人 已经建立了高级MRI技术来捕获诸如心脏和脑血管等测量值 同一MRI检查中的血液动力学和大脑结构。测量主动脉血流动力学（例如，脉搏波 速度），以及与脑血管疾病有关的颅内搏动性和脑异常 阿尔茨海默氏病将提供有关基础血液动力学机制的关键见解。 拟议的研究将使用先进的MRI技术进行心脏血流动力学的全面分析 耦合。该项目将利用心血管成像中的新发展，尤其是使用4D Flow MRI， 能够完全表征复杂的3D血液动力学，例如血流速度，反向流量映射 和主动脉脉冲波速度。高速加速4D流MRI的方法学进步启用集成 单个MRI中大脑的定量结构分析的心血管和颅内4D流MRI 考试。这种结合的心脏和脑血管4D流MRI与定量的脑成像（即“心脑” MRI”将用于分析衰老和阿尔茨海默氏病的血液动力学耦合。该提议的目的 是使用新型的心脑MRI系统评估正常衰老的血液动力偶联关系， 和高血压，并将这种技术应用于阿尔茨海默氏病的试点研究。在目标1和2中，心脑 MRI将在健康的成年人和中年和后期的患有高血压的成年人中进行评估，以确定 正常衰老的心脑MRI测量与高血压如何加剧大脑之间的关系 随着衰老的变化。在AIM 3中，心脑MRI将在阿尔茨海默氏病的试点研究中应用 初步关系并帮助计划未来的研究。该K01将提供临床和神经影像学的培训 衰老和阿尔茨海默氏病的各个方面，以进一步建立独立研究计划的目标 专注于认知衰老和痴呆中的心脑血流动力学耦合，包括 阿尔茨海默氏病。