Highly Efficient MRI Pulse Sequences for High Resolution Physiological and Functional Brain Imaging

用于高分辨率生理和功能脑成像的高效 MRI 脉冲序列

• 批准号: 10326081
• 负责人: Alexander Beckett
• 金额: $ 134.02万
• 依托单位: ADVANCED MRI TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10326081
• 关键词: 3-Dimensional; Acceleration; Area; Blood; Blood Vessels; Brain; Brain imaging; Cerebrovascular Circulation; Clinical Protocols; Code; Computer software; Data; Deep Brain Stimulation; Development; Diagnosis; Disease; Documentation; Drainage procedure; Echo-Planar Imaging; Environment; Evaluation; Functional Imaging; Functional Magnetic Resonance Imaging; Human; Image; Imaging Techniques; Magnetic Resonance Imaging; Measurement; Measures; Medical; Neocortex; Neurons; Neuropsychology; Noise; Patients; Performance; Physicians; Physics; Physiologic pulse; Physiological; Process; Resolution; Scientist; Signal Transduction; Site; Slice; Software Tools; Specificity; Speed; Spin Labels; Techniques; Technology; Testing; Time; Traumatic Brain Injury; Validation; Variant; Venous; Work; analysis pipeline; blood flow measurement; blood oxygen level dependent; brain abnormalities; cerebral blood volume; data analysis pipeline; high resolution imaging; improved; innovation; nervous system disorder; neural circuit; neuronal circuitry; neurovascular; non-invasive imaging; novel; protocol development; public repository; quality assurance; reconstruction; relating to nervous system; temporal measurement

Summary This project will develop MRI physiological imaging with higher spatial and temporal resolution, larger brain coverage, and faster accelerated pulse sequences. The physiologic images have contrasts of microvascular- weighted blood oxygen level dependent (BOLD), cerebral blood flow (CBF) and cerebral blood volume (CBV). Importantly, the techniques to be developed are largely insensitive to venous blood contributions to signal, unlike traditional BOLD echo planar imaging (EPI) sequences, and thus they are extremely useful for precision imaging of physiological markers in neurological disorders and for higher specificity in cortical layer fMRI, enabling higher granularity in human neurocircuitry imaging. Novel acceleration techniques for each pulse sequence will be incorporated to increase slice-volume coverage and improve signal to noise ratio (SNR) and point spread function (PSF) in signal localization. Sequence development and evaluations will be performed at several 3T and 7T imaging sites. We will develop a software package with advanced variants of several pulse sequences: zoomed 3D gradient-and-spin-echo (GRASE), arterial spin labeling (ASL) for CBF imaging, slice- saturation slab- inversion vascular space occupancy (SS-SI-VASO) for CBV imaging, and the novel VASO technique with “multiple acquisitions with global excitation cycling” (MAGEC)-VASO to achieve whole brain coverage. The software package will also include a modular analysis pipeline for use by neuroscientists and physicians without the need for extensive MR-physics or coding expertise. Achieving non-invasive imaging of neuronal circuits in the human brain will allow neuroscientists to study normal brain processes and allow medical scientists to study neurocircuitry changes and neurological diseases. Currently, high-resolution fMRI technology could be used to identify fMRI of neural activity at different cortical depths, but is severely limited by poorly localized signal from venous drainage in the cortex. This project innovates new, robust 3D fMRI imaging sequences that eliminate venous contamination, thus affording high fidelity mapping of fine-scale neuronal circuitry compared to current gradient echo EPI BOLD imaging.

概括 该项目将以较高的空间和临时分辨率开发MRI生理成像，更大的大脑 覆盖范围和更快的加速脉冲序列。生理图像具有微血管的对比度 加权血氧水平依赖性（BOLD），脑血流量（CBF）和脑血体积（CBV）。 重要的是，要开发的技术在很大程度上对信号的静脉血液贡献不敏感， 与传统的大胆回声平面成像（EPI）序列不同，因此它们非常有用，可用于精确 神经系统疾病中物理标记的成像和为较高的皮质层fMRI的特异性， 在人类神经循环成像中实现较高的粒度。每个脉冲的新型加速技术 序列将合并以增加切片体积覆盖范围并提高信号与噪声比（SNR）和 信号定位中的点扩散函数（PSF）。序列开发和评估将在 几个3T和7T成像位点。我们将开发一个具有多个脉冲的高级变体的软件包 序列：缩放3D梯度和自旋回波（GRASE），用于CBF成像的动脉自旋标记（ASL），切片 - CBV成像的饱和平板反转血管空间占用（SS-SI-VASO）和新型的VASO 具有“全球兴奋骑行的多次收购”（MAGEC） - vaso的技术 覆盖范围。该软件包还将包括一个模块化分析管道，以供神经科学家和 医生无需广泛的MR身体学或编码专业知识。实现非侵入性成像 人脑中的神经元电路将使神经科学家能够研究正常的大脑过程并允许 医学科学家研究神经循环的变化和神经系统疾病。目前，高分辨率fMRI 技术可用于识别不同皮质深度的神经活动fMRI，但受到严重限制 皮质中静脉排水的局部信号不良。该项目创新了新的，强大的3D fMRI成像 消除静脉污染的序列，从而提供高尺度神经元的高忠诚度图 与当前梯度回声EPI大胆成像相比。