Image Data Acquisition, Analysis, and Modeling Core

图像数据采集、分析和建模核心

基本信息

批准号：
9275044
负责人：
SHENG-KWEI SONG
金额：
$ 20.44万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-25 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9275044
关键词：
Acute Address Affect Agar Animal Model Animals Autopsy Axonal Transport Back Biological Markers Biopsy Blood - brain barrier anatomy Brain Cell Polarity Cells Cellularity Central Nervous System Diseases Chronic Clinical Trials Communities Computer software Conflict (Psychology)Data Data Analyses Decision Making Demyelinations Development Diagnostic Diffusion Diffusion Magnetic Resonance Imaging Disease Edema Endothelial Cells Ensure Experimental Autoimmune Encephalomyelitis Experimental Designs Extravasation Funding Gel Gold Histologic Histology Human Human Resources Image Immunohistochemistry Impairment Individual Infiltration Inflammation Magnetic Resonance Imaging Manganese Manuals Maps Measurement Measures Methods Modeling Multiple Sclerosis Multiple Sclerosis Lesions Mus Myelin Myelin Sheath Neuraxis Optic Nerve Outcome Measure Pathogenesis Pathology Patient Monitoring Patients Procedures Program Research Project Grants Protocols documentation Readability Regulation Reporting Resolution Sampling Services Signal Transduction Spinal Cord Staining method Stains Statistical Data Interpretation Supervision Testing Time Tissues Translating Treatment Efficacy Validation Visual Acuity Water Work axon injury data acquisition data management design head-to-head comparison human subject imaging biomarker imaging modality imaging study improved in vivo in vivo imaging member multiple sclerosis patient neuropathology novel therapeutics prevent professor spectrograph success tissue phantom tool white matter white matter injury

项目摘要

Objectives: The Image Data Acquisition, Analysis, and Modeling Core will be responsible for (1) supporting the MRI experimental design and execution for all projects; (2) developing an objective MRIimmunohistochemistry validation method; (3) improving data acquisition efficiency; (4) streamlining postprocessing procedures; and (5) participating in data interpretation and dissemination of all MRI results. Core C will explore the possibility of using T2 relaxometry, myelin water imaging, to detect and quantify multiple pathologies in CNS white matter. Core Services: Core C is specifically designed to support all Projects of this program project grant, not a general purposed service core unit to the community. Outside studies relevant to the scope of this PPG will be considered after the approval of Executive Committee (Drs. Cross, Klein, Song and Trinkaus). It is the responsibility of Core C to perform all necessary tasks assuring the success of all MRI measurements. Decision-Making: During the planning of this renewal of this PPG, members of the executive committee have met and discussed regularly on specific tasks of Core C. Thus, the Core Co-directors Song and Kim will work closely with all Project and Core personnel to perform the proposed MRI studies and modify if necessary as projects progress. Any conflict in experimental execution will first be resolved between the involved Project/Core directors and Song/Kim team. Any unresolved conflict will be resolved through the PPG Executive Committee. The data interpretation and dissemination will be conducted by all involved Project/Core personnel, submitting to Executive Committee for final approval.

目标：图像数据采集、分析和建模核心将负责 (1) 支持所有项目的MRI实验设计和执行； (2) 开发客观的 MRI 免疫组织化学验证方法； (3)提高数据采集效率； (4) 简化后处理程序； (5) 参与所有 MRI 结果的数据解释和传播。核 C 将探索使用 T2 弛豫测量、髓磷脂水成像来检测和量化多个中枢神经系统白质病变。核心服务：核心 C 是专门为支持该计划项目拨款的所有项目而设计的，而不是为社区提供通用服务的核心单元。与本 PPG 范围相关的外部研究将经执行委员会（Cross、Klein、Song 和 Trinkaus 博士）批准后予以考虑。它是核心 C 负责执行所有必要的任务，确保所有 MRI 测量的成功。决策：在规划本次 PPG 更新期间，执行委员会成员定期会面并讨论核心 C 的具体任务。因此，核心联合董事 Song 和 Kim 将与所有项目和核心人员密切合作，执行拟议的 MRI 研究并修改如果随着项目的进展是必要的。实验执行中的任何冲突将首先在涉及项目/核心总监和 Song/Kim 团队。任何未解决的冲突将通过 PPG 执行委员会。数据解释和传播将由所有相关人员进行项目/核心人员，提交执行委员会最终批准。