A cohort study of air pollution, lung cancer, and COPD in Los Angeles County

洛杉矶县空气污染、肺癌和慢性阻塞性肺病的队列研究

基本信息

批准号：
9543858
负责人：
Iona C Cheng
金额：
$ 63.58万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9543858
关键词：
1,3-Butadiene Address Affect African Air Air Pollutants Air Pollution Airborne Particulate Matter American Area Aromatic Polycyclic Hydrocarbons Benzene Biological Biological Markers C-reactive protein California Carcinogens Cause of Death Characteristics Chemicals Chronic Obstructive Airway Disease Classification Cohort Studies County Data Data Quality Development Diesel Exhaust Disease Dose Engine Exhaust Epidemiology Ethnic Origin Exposure to Foundations Gasoline Gender Goals Health Health Priorities Health behavior Histology Human Individual International Agency for Research on Cancer Knowledge Latino Life Style Link Literature Los Angeles Malignant neoplasm of lung Measures Medicare Molecular Molecular Epidemiology Motor Neighborhoods Occupational Exposure Participant Particulate Particulate Matter Pattern Population Public Health Quality Control Questionnaires Race Research Infrastructure Risk Role Serum Smoking Status Socioeconomic Status Subgroup United States Woman Work ambient air pollution cancer risk carcinogenicity coarse particles cohort design disorder risk ethnic difference ethnic diversity exhaust follow-up improved inflammatory marker lifestyle factors pollutant prospective racial and ethnic response sex surveillance data ultrafine particle

项目摘要

PROJECT SUMMARY/ABSTRACT While air quality has improved over the past decades, air pollution is ubiquitous and the absolute number of people affected is a major public health concern. In 2013, the International Agency for Research on Cancer classified outdoor air pollution and particulate matter (PM) as carcinogenic to humans and a cause of lung cancer. This recent classification calls for prompt action to address the gaps in the epidemiologic literature on the role of air pollution in increasing the risks for lung cancer and chronic obstructive pulmonary disease (COPD), two of the top four causes of death in the United States. Thus, we designed the following aims, leveraging the rich environmental, lifestyle, neighborhood, molecular, and surveillance data of the long- standing Multiethnic Cohort (MEC) Study. We propose in Aim 1 to quantify and characterize the associations between estimated exposure to airborne particulate matter (PM2.5, PM10) and lung cancer risk among 112,023 California (CA) MEC participants with 3,057 lung cancer cases. In Aim 2 we will quantify and characterize the associations between PM2.5, PM10, and risk of COPD among 46,000 CA MEC participants with Medicare data, including 11,508 COPD cases. In Aim 3 we will investigate the relationships between PM2.5, PM10, and serum levels of the inflammatory marker, C-reactive protein, already available in 7,566 CA MEC participants. In each of these aims, we will also assess the extent to which these PM-associations are modified by co-pollutants (e.g., NO2 and NOx traffic markers), individual-level (e.g., race/ethnicity, gender, smoking status), and neighborhood-level (e.g., socioeconomic status, ethnic enclave) factors. The strengths of this proposal include: (1) it represents one of the first prospective air pollution and lung cancer and COPD study to include sizeable numbers of Africans and Latinos (n=80,489); (2) it addresses the complexity of air pollution assessment by evaluating three separate measures of estimated air pollutants having different advantages and functionalities; (3) it leverages multiple measures of exposures over the same periods to provide a greater depth in understanding exposure patterns and associations with risk; and (4) it incorporates a molecular epidemiology component. Through this work, we expect to increase our understanding of the burdens of lung cancer and COPD associated with air pollution exposure and to identify differences in associations among important subgroups.

项目概要/摘要虽然空气质量在过去几十年里有所改善，但空气污染却无处不在，而且空气污染的绝对数量受影响的人是一个重大的公共卫生问题。 2013年，国际癌症研究机构将室外空气污染和颗粒物 (PM) 列为人类致癌物和肺癌病因癌症。最近的分类要求立即采取行动，以弥补流行病学文献中的空白空气污染在增加肺癌和慢性阻塞性肺病风险中的作用（慢性阻塞性肺病）是美国四大死因之一。因此，我们设计了以下目标，利用长期丰富的环境、生活方式、邻里、分子和监测数据常设多种族队列 (MEC) 研究。我们在目标 1 中建议量化和表征关联 112,023 人中估计接触空气颗粒物（PM2.5、PM10）与肺癌风险之间的关系加利福尼亚州 (CA) MEC 参与者有 3,057 例肺癌病例。在目标 2 中，我们将量化并描述根据 Medicare 数据，46,000 名 CA MEC 参与者中 PM2.5、PM10 与 COPD 风险之间的关联，其中包括 11,508 例慢性阻塞性肺病病例。在目标 3 中，我们将研究 PM2.5、PM10 和血清之间的关系炎症标志物 C 反应蛋白的水平已在 7,566 名 CA MEC 参与者中获得。在每个在这些目标中，我们还将评估这些 PM 关联被共污染物改变的程度（例如，二氧化氮和氮氧化物流量标记）、个人层面（例如，种族/民族、性别、吸烟状况）以及社区层面（例如社会经济地位、种族飞地）因素。该提案的优点包括： (1) 它代表了第一个前瞻性空气污染与肺癌和慢性阻塞性肺病研究，其中包括大量研究非洲人和拉丁美洲人的数量（n=80,489）； (2) 它解决了空气污染评估的复杂性评估具有不同优点和功能的估计空气污染物的三种单独测量方法； (3) 它利用同一时期的多种风险敞口衡量标准来提供更深入的了解了解暴露模式以及与风险的关联； (4)它结合了分子流行病学成分。通过这项工作，我们希望加深对肺癌负担的了解，慢性阻塞性肺病与空气污染暴露相关，并确定重要因素之间关联的差异亚组。