DEVELOPMENT OF SLEEP STATES AND SIDS RISK

睡眠状态和婴儿猝死综合症风险的发展

• 批准号: 2198643
• 负责人: RONALD Marven HARPER
• 金额: $ 14.77万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-12-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2198643
• 关键词: REM sleep; arousal; circadian rhythms; developmental neurobiology; disease /disorder proneness /risk; electrocardiography; electroencephalography; electromyography; heart rate; human subject; infant human (0-1 year); polygraphy; respiratory center dysfunction; respiratory muscles; siblings; sleep; sleep regulatory center; statistics /biometry; sudden infant death syndrome

This project will examine the development of physiological measures and sleep states in normal infants and in infants at risk for the sudden infant death syndrome (SIDS). The objective is to find physiological characteristics that differentiate infants who later succumbed from those who survived, and apply these characteristics to a yet-unexamined group at risk for SIDS. Infants who later succumbed to SIDS, and two groups of infants at increased risk of SIDS, siblings of SIDS victims and infants who experienced a life-threatening event, will be compared with age-matched controls using data already collected. The objectives are based on the assumptions 1) that SIDS victims succumb from a failure of mechanisms that normally allow a state transition when the infant is exposed to a life- threatening challenge, and 2) that physiological signs, measured during different states, will provide suggestions of the mechanisms that lead to a failure to respond adequately to challenges. Instantaneous and long term changes in cardiac and respiratory intervals, obtained during each sleep- waking state, will be assessed over the first 6 months of life in normal infants and AIDS-siblings, and in single recordings of infants who experienced a life threatening event or subsequently died of SIDS. The interaction between physiological variables that define sleep states will be assessed using linear time-domain filtering procedures and frequency- domain spectral techniques, together with nonlinear dynamic procedures including phase-plane plots, to determine if development of moment-to- moment activity and interactions between variables are altered in infants at risk. The temporal characteristics of sleep-walking states, including distribution of states across the night, state transition probabilities, periodic organization, and time of night modulation of sleep and waking physiology will be compared between control infants and infants at risk. Relationships of moment-to-moment physiological alterations in activity to the 3-4 h "feeding rhythm" and to time-of-night will be quantified for each group. Assessment of instantaneous variation in cardiac and respiratory intervals will include Poincare procedures and phase-plane plots, together with ANOVA assessment of dispersion at different rates. Multivariate statistical procedures, including stepwise logistic regression and discriminant analysis, will also be used to assess differences among risk groups.

该项目将研究生理措施的发展和 正常婴儿和有可能突然婴儿的婴儿的睡眠状态 死亡综合征（SIDS）。 目的是找到生理 与后来屈服的婴儿有区别的特征 谁幸存，并将这些特征应用于尚未证明的群体 小岛屿发展中国家的风险。 后来屈服于小岛的婴儿，两组 小岛屿发展中国家的风险增加的婴儿，小溪受害者和婴儿的兄弟姐妹 经历了威胁生命的活动，将与年龄匹配 使用已经收集的数据的控件。 这些目标是基于 假设1）受害者被隔绝的机制失败而屈服于 通常，当婴儿暴露于生命时，允许国家过渡 - 威胁性挑战，以及2）在 不同的国家将提供导致一个机制的建议 未能对挑战做出充分的反应。 瞬间和长期 每次睡眠期间获得的心脏和呼吸间隔的变化 醒来状态，将在正常生命的前6个月进行评估 婴儿和艾滋病兄弟姐妹，以及婴儿的单一记录 经历了威胁生命的事件，或者随后死于小岛屿发展中国家。 这 定义睡眠状态的生理变量之间的相互作用将 使用线性时域过滤程序和频率进行评估 域光谱技术以及非线性动态过程 包括相平面图，以确定力矩到 - 是否发展 婴儿的力矩活动和变量之间的相互作用发生了变化 有风险。 睡眠状态的时间特征，包括 整个晚上的国家分布，国家过渡概率， 周期性的组织以及夜间睡眠和醒来的时间 将比较有风险的对照婴儿和婴儿之间的生理学。 矩与时刻的生理改变与活动的关系 3-4 h“喂食节奏”和晚上的时间将被量化 团体。 评估心脏和呼吸系统的瞬时变化 间隔将包括繁殖程序和相平面图，一起 通过方差分析以不同的速度评估分散体。 多变量 统计程序，包括逐步逻辑回归和 判别分析也将用于评估风险之间的差异 组。