Affect Regulation and Adolescent Brain Maturation

影响调节和青少年大脑成熟

• 批准号: 6779064
• 负责人: Ronald E. Dahl
• 金额: $ 37.13万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6779064
• 关键词: adolescence (12-20); behavioral /social science research tag; bioimaging /biomedical imaging; child psychology; choice; clinical research; decision making; evoked potentials; functional magnetic resonance imaging; human puberty; human subject; interdisciplinary collaboration; meeting /conference /symposium; mood disorders; neuropsychology; neuroregulation; sleep deprivation; technology /technique development; training

DESCRIPTION (provided by applicant): This application describes a Research Network aimed at conceptual and methodological advances in understanding affect dysregulation in adolescence. The central theme for this project is the development and refinement of measures of affect regulation that can be used to investigate neurobehavioral systems in adolescents within a developmental framework. These include tasks that can be used in functional MRI and ERP (event-related potential) studies to examine the development of neurobehavioral systems in both clinical and normative populations of adolescents. It is also important to devise experimental paradigms that address clinically relevant and ecologically valid aspects of emotion and its regulation. This will require developing better conceptual models and formulating specific hypotheses about affective changes in developmental pathways of emotional disorders in adolescence. The long-term goals of this work are to address clinically relevant questions-to identify developmental pathways and mechanisms of affect dysregulation that can inform treatment strategies for early-onset depression, anxiety, and other emotional disorders emerging in adolescence. We focus on adolescence because this developmental phase represents a period of increased vulnerabilities for emotional disorders, yet also presents opportunities for early intervention. Ultimately, mechanistic understanding of the development of affect regulation can lead to prevention strategies targeting high-risk populations prior to the onset of more serious emotional disorders. A deeper understanding of affect regulation in adolescence may also provide insights into behaviors such as increased sensation seeking, risk-taking, and substance use-common behaviors in adolescence that can lead to serious consequences. The specific aims of this research network are: (1) To develop and refine fMRI and ERP tasks of emotion regulation that can be used in clinical and developmental studies of older children and adolescents. (2) To develop and refine behavioral and experience-sampling methods of assessing emotion and its regulation in the natural environments of adolescents. (3) To improve heuristic models of affect regulation and dysregulation during adolescent development within a cognitive/affective neuroscience framework. (4) To provide outstanding interdisciplinary training experiences for young investigators.

描述（由申请人提供）：本申请描述了一个研究网络，旨在理解青春期影响失调的概念和方法上的进展。该项目的中心主题是开发和完善情感调节措施，可用于在发展框架内研究青少年的神经行为系统。其中包括可用于功能性 MRI 和 ERP（事件相关电位）研究的任务，以检查青少年临床和正常人群中神经行为系统的发育。设计解决情绪及其调节的临床相关和生态有效方面的实验范式也很重要。这将需要开发更好的概念模型并制定关于青春期情绪障碍发展途径的情感变化的具体假设。这项工作的长期目标是解决临床相关问题——确定情感失调的发展途径和机制，为早发性抑郁、焦虑和青春期出现的其他情绪障碍的治疗策略提供信息。我们关注青春期，因为这个发育阶段代表着情绪障碍的脆弱性增加的时期，但也提供了早期干预的机会。最终，对情感调节发展的机械理解可以在更严重的情绪障碍发作之前制定针对高危人群的预防策略。对青春期情感调节的更深入了解还可以深入了解诸如增加感觉寻求、冒险和物质使用等行为，这些行为是青春期常见的可能导致严重后果的行为。该研究网络的具体目标是：（1）开发和完善情绪调节的 fMRI 和 ERP 任务，可用于年龄较大儿童和青少年的临床和发育研究。 (2) 开发和完善评估青少年自然环境中情绪及其调节的行为和经验采样方法。 (3) 在认知/情感神经科学框架内改进青少年发展期间情感调节和失调的启发式模型。 （4）为年轻研究者提供优秀的跨学科培养经验。