Brain Imaging in Fetal Alcohol Exposed Delinquents

胎儿酒精暴露不良者的脑成像

• 批准号: 7133704
• 负责人: SUSANNA FRYER
• 金额: $ 2.89万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-16 至 2008-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7133704
• 关键词: adolescence (12-20); behavioral /social science research tag; bioimaging /biomedical imaging; brain disorder diagnosis; brain electrical activity; brain imaging /visualization /scanning; brain mapping; brain subcortex; clinical research; executive function; fetal alcohol syndrome; frontal lobe /cortex; functional magnetic resonance imaging; human subject; juvenile delinquency; longitudinal human study; mental health epidemiology; neural inhibition; neuropsychology; neurotoxicology; predoctoral investigator; substance abuse related behavior

DESCRIPTION (provided by applicant): Prenatal exposure to alcohol is associated with a wide array of behavioral and cognitive impairments, including attention deficits and decreases in general intelligence. It has been suggested that alcohol exposed individuals exhibit increased delinquent behavior and are overrepresented in criminal justice systems. However, there is little research on the effects of alcohol exposure in delinquent youth, particularly with regard to how alcohol-exposure induced brain damage might inform the etiology of disruptive behaviors. The current proposal aims to use functional neuroimaging to examine the hypothesized role of response inhibition executive functioning deficits in fetal alcohol-exposed delinquents. Specifically, the proposed study will investigate the integrity of frontal-sub cortical functioning in alcohol-exposed versus non-exposed juvenile delinquents by using a standard disinhibition (go no-go) neuroimaging task. This project will help to characterize the neural correlates associated with both delinquency and prenatal alcohol exposure, and will investigate the degree to which fetal alcohol exposure discriminates among delinquent neurocogntive profiles.

描述（由申请人提供）：产前暴露于酒精与广泛的行为和认知障碍有关，包括注意力缺陷和一般智能中的减少。有人认为，酒精暴露的人表现出更大的犯罪行为，并且在刑事司法系统中的代表过多。但是，关于违法青年酒精暴露的影响的研究很少，特别是关于酒精暴露诱发的脑损伤可能会导致破坏性行为的病因。当前的提案旨在使用功能性神经影像来检查抑制胎儿酒精暴露犯罪的反应抑制执行功能缺陷的假设作用。具体而言，拟议的研究将研究酒精暴露与非暴露的少年中额叶纤维皮质功能的完整性 通过使用标准的抑制（GO No-Go）神经影像学任务进行犯罪。这个项目将有助于 表征与拖欠和产前酒精暴露有关的神经相关的神经相关的，并将研究胎儿酒精暴露在拖延神经认知特征之间区分胎儿酒精的程度。