Adolescent Social Phobia and Neurophysiological Function

青少年社交恐惧症与神经生理功能

• 批准号: 6617116
• 负责人: Christopher Stephen Monk
• 金额: $ 14.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6617116
• 关键词: adolescence (12-20); anxiety; behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; face expression; fear; functional magnetic resonance imaging; human subject; middle childhood (6-11); neuropsychological tests; neuropsychology; patient oriented research; phobias; social adjustment

DESCRIPTION (provided by applicant): The goal of this Research Career Award is to develop the applicant's ability to conduct independent translationally oriented clinical research. The applicant is trained in experimental methodology, child psychology and neuroscience. This background enables the applicant to critically review the relevant literature and develop methodological procedures based on neuroscience models that can be adapted to study brain function in children. This grant would provide the training and mentoring necessary for the applicant to use these methods and theories to begin to reveal the neural correlates of developmental psychopathology. The applicant will be mentored in child psychiatry, psychiatric diagnostic procedures and in the use of adapting neuroimaging procedures for the study of psychiatric disorders. Animal research provides an effective pathophysiological model for anxiety. Using fear provoking paradigms, animal model approaches delineate a neural circuit that includes the amygdala and the orbito-frontal cortex in anxiety-related behaviors. Research in adults with anxiety disorders documents perturbations in the same regions in response to fear provoking stimuli, particularly emotionally evocative faces. However, very little work has been conducted to document comparable perturbations in adolescents with anxiety. The research objective for the present proposal is to use animal models of anxiety as a guide to reveal the neurophysiological and behavioral correlates of adolescent social phobia. Specifically, healthy adolescents and those with social phobia will be presented with fear provoking stimuli (emotional faces), while brain activation is measured with functional magnetic resonance imaging. Such work will help to reveal the neurophysiological correlates of adolescent social phobia. The long-term goal is to identify neurobiological and behavioral events that underlie the development of childhood anxiety disorders.

描述（由申请人提供）：本研究职业奖的目标是发展申请人进行独立以翻译为导向的临床研究的能力。申请人接受了实验方法，儿童心理学和神经科学的培训。该背景使申请人能够批判性地审查相关文献，并基于神经科学模型制定方法论程序，这些方法可以适应儿童的大脑功能。这项赠款将为申请人使用这些方法和理论开始揭示发育心理病理学的神经相关性提供必要的培训和指导。申请人将在儿童精神病学，精神病学诊断程序以及使用适应神经影像学的过程中进行指导。 动物研究为焦虑提供了有效的病理生理模型。使用恐惧引起的范例，动物模型方法描绘了一个神经回路，其中包括杏仁核和焦虑相关行为中的甲状腺素皮层。对焦虑症的成年人进行的研究，以应对恐惧刺激，尤其是情感令人回味的面孔，在同一地区扰动。但是，很少有工作要记录焦虑症的青少年的可比扰动。本提案的研究目标是使用焦虑动物模型作为揭示青少年社会恐惧症的神经生理和行为相关性的指南。具体来说，健康的青少年和具有社交恐惧症的青少年将以令人发指的刺激（情感面孔）呈现，而通过功能性磁共振成像来测量大脑的激活。这种工作将有助于揭示青少年社会恐惧症的神经生理学相关性。长期目标是确定儿童焦虑症发展构成的神经生物学和行为事件。