Emotion Dysregulation in Girls at Risk for Depression

有抑郁风险的女孩的情绪失调

• 批准号: 7106810
• 负责人: IAN H GOTLIB
• 金额: $ 54.36万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106810
• 关键词: adolescence (12-20); behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; clinical research; cognition; cortisol; emotional adjustment; family genetics; female; functional magnetic resonance imaging; genetic susceptibility; human subject; major depression; mother child interaction; neural information processing; neuroendocrine system; neuroimaging; patient oriented research; psychological stressor; psychological tests; psychopathology; women' s health

DESCRIPTION (provided by applicant): Depression is among the most prevalent and costly of all psychiatric disorders. A pressing public health need is to identify factors that play a role in increasing individuals' vulnerability to depression. Offspring of parents with depression are at heightened risk for the development of this disorder. Consequently, assessing these children is of critical importance in elucidating factors and mechanisms associated with this risk. The proposed integrative project is designed to examine biological, cognitive, and psychosocial factors and mechanisms that may elevate the risk for psychopathology in never-disordered 11 - to14-year-old daughters of mothers with a history of recurrent Major Depressive Disorder. We will compare the functioning of this group of girls with that of daughters in two additional age-matched groups: formerly depressed daughters of recurrent depressed mothers, and never-disordered daughters of mothers with no history of psychopathology. We propose to assess two broad constructs that are of critical importance in understanding the increased risk for psychopathology of daughters of depressed mothers: (1) the daughters' perception and evaluation of stressors in their environment, which determine their immediate response to the stressors; and (2) the daughters' regulatory skills in response to the stressors, which determine the long-term consequences of exposure to the stressors. Our study is unique in combining brain imaging techniques, measurement of both diurnal and reactive cortisol levels, assessment of information-processing biases, and self-report measures to assess emotion dysregulation and stress reactivity in daughters of depressed mothers. Working from a diathesis-stress perspective, we will administer stress- and mood-induction procedures prior to assessing the constructs of interest. We will also conduct an 18-month follow-up assessment to examine whether difficulties in stress reactivity and emotion regulation assessed in a nondepressed state predict the onset and/or the recurrence of depressive episodes. These data promise to help us gain a more comprehensive understanding of the interplay of stress reactivity, neuroendocrine functioning, emotion regulation, cognitive processes, and patterns of neural reactivity in placing children of depressed mothers at elevated risk for affective disorder, and will identify critical areas of dysfunction that may serve as targets for prevention programs.

描述（由申请人提供）：抑郁症是所有精神疾病中最普遍且最昂贵的疾病之一。迫切的公共卫生需求是确定导致个人更容易患抑郁症的因素。患有抑郁症的父母的后代患这种疾病的风险更高。因此，评估这些儿童对于阐明与这种风险相关的因素和机制至关重要。拟议的综合项目旨在检查生物学、认知和心理社会因素和机制，这些因素和机制可能会增加母亲患有复发性重度抑郁症病史的从未患过疾病的 11 至 14 岁女儿的精神病理学风险。我们将把这组女孩的功能与另外两个年龄匹配组的女儿的功能进行比较：经常抑郁的母亲的以前抑郁的女儿，以及没有精神病史的母亲的从未患过抑郁症的女儿。我们建议评估两个广泛的结构，这对于理解抑郁母亲的女儿患精神病理学的风险增加至关重要：（1）女儿对其环境中压力源的感知和评估，这决定了她们对压力源的立即反应； (2) 女儿们应对压力源的调节技能，这决定了暴露于压力源的长期后果。我们的研究的独特之处在于结合了大脑成像技术、昼夜皮质醇水平和反应性皮质醇水平的测量、信息处理偏差的评估以及自我报告措施来评估抑郁母亲的女儿的情绪失调和压力反应性。从素质压力的角度出发，我们将在评估感兴趣的结构之前管理压力和情绪诱导程序。我们还将进行为期 18 个月的随访评估，以检查在非抑郁状态下评估的压力反应和情绪调节困难是否可以预测抑郁发作的发作和/或复发。这些数据有望帮助我们更全面地了解压力反应、神经内分泌功能、情绪调节、认知过程和神经反应模式之间的相互作用，使抑郁母亲的孩子患情感障碍的风险升高，并将确定关键领域可以作为预防计划目标的功能障碍。