Emotion Dysregulation in Girls at Risk for Depression

有抑郁风险的女孩的情绪失调

• 批准号: 7106810
• 负责人: IAN H GOTLIB
• 金额: $ 54.36万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106810
• 关键词: adolescence (12-20); behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; clinical research; cognition; cortisol; emotional adjustment; family genetics; female; functional magnetic resonance imaging; genetic susceptibility; human subject; major depression; mother child interaction; neural information processing; neuroendocrine system; neuroimaging; patient oriented research; psychological stressor; psychological tests; psychopathology; women' s health

DESCRIPTION (provided by applicant): Depression is among the most prevalent and costly of all psychiatric disorders. A pressing public health need is to identify factors that play a role in increasing individuals' vulnerability to depression. Offspring of parents with depression are at heightened risk for the development of this disorder. Consequently, assessing these children is of critical importance in elucidating factors and mechanisms associated with this risk. The proposed integrative project is designed to examine biological, cognitive, and psychosocial factors and mechanisms that may elevate the risk for psychopathology in never-disordered 11 - to14-year-old daughters of mothers with a history of recurrent Major Depressive Disorder. We will compare the functioning of this group of girls with that of daughters in two additional age-matched groups: formerly depressed daughters of recurrent depressed mothers, and never-disordered daughters of mothers with no history of psychopathology. We propose to assess two broad constructs that are of critical importance in understanding the increased risk for psychopathology of daughters of depressed mothers: (1) the daughters' perception and evaluation of stressors in their environment, which determine their immediate response to the stressors; and (2) the daughters' regulatory skills in response to the stressors, which determine the long-term consequences of exposure to the stressors. Our study is unique in combining brain imaging techniques, measurement of both diurnal and reactive cortisol levels, assessment of information-processing biases, and self-report measures to assess emotion dysregulation and stress reactivity in daughters of depressed mothers. Working from a diathesis-stress perspective, we will administer stress- and mood-induction procedures prior to assessing the constructs of interest. We will also conduct an 18-month follow-up assessment to examine whether difficulties in stress reactivity and emotion regulation assessed in a nondepressed state predict the onset and/or the recurrence of depressive episodes. These data promise to help us gain a more comprehensive understanding of the interplay of stress reactivity, neuroendocrine functioning, emotion regulation, cognitive processes, and patterns of neural reactivity in placing children of depressed mothers at elevated risk for affective disorder, and will identify critical areas of dysfunction that may serve as targets for prevention programs.

描述（由申请人提供）：抑郁症是所有精神疾病中最普遍，最昂贵的抑郁症之一。紧迫的公共卫生需求是确定在增加个人对抑郁症的脆弱性方面发挥作用的因素。抑郁症的父母的后代有这种疾病发展的风险。因此，评估这些儿童至关重要，在阐明与这种风险相关的因素和机制中至关重要。拟议的综合项目旨在检查生物学，认知和社会心理因素和机制，这些因素和机制可能会在从未分解的11至14岁的母亲的女儿中，可能会提高心理病理的风险，患有经常性重大抑郁症的史。我们将将这群女孩的功能与另外两个年龄匹配的群体的女儿的功能进行比较：以前是沮丧的母亲的沮丧女儿，以及没有精神病学史的母亲的女儿。我们建议评估两个广泛的结构，这些结构对于理解沮丧母亲女儿的心理病理风险的增加至关重要：（1）女儿对环境中压力源的看法和评估，这决定了他们对压力源的直接反应； （2）女儿对压力源的调节技能，这决定了暴露于压力源的长期后果。我们的研究在结合脑成像技术，昼夜和反应性皮质醇水平的测量，信息处理偏见的评估以及自我报告措施评估情绪失调和压抑母亲女儿的压力反应性方面是独一无二的。从素质变化的角度工作，我们将在评估感兴趣的结构之前对压力和情绪诱导程序进行管理。我们还将进行18个月的随访评估，以检查在不抑制状态下评估的压力反应性和情绪调节的困难是否可以预测抑郁发作的发作和/或复发。这些数据有望帮助我们对压力反应性，神经内分泌功能，情绪调节，认知过程以及神经反应性的模式的相互作用有更全面的了解，以使抑郁母亲的孩子处于情感障碍风险升高的情况下，并将确定可能是预防计划的关键功能障碍领域。