Cooperative Breast Cancer Tissue Resource (CBCTR)

合作乳腺癌组织资源 (CBCTR)

• 批准号: 6686152
• 负责人: Clara MILIKOWSKI
• 金额: $ 17.4万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6686152
• 关键词: automated medical record system; breast neoplasms; cancer registry /resource; clinical research; cooperative study; data collection; human subject; human tissue; microarray technology; sample collection; tissue resource /registry

DESCRIPTION (provided by applicant) Specific Aims The Cooperative Breast Cancer Tissue Resource (CBCTR) was developed, starting in 1993, in response to a cooperative agreement between the National Cancer Institute and four sites in the United States to provide breast cancer tissue to the biomedical research community for the study of clinical markers of tumor prognosis and the evaluation of promising diagnostic tests based on these markers. The current application is a response to a Letter Request for Applications for Recompetition of the CBCTR for a further three years of funding. Specifically, these four institutions individually and together will 1. Continue the provision of specimens to researchers in the community from the files of the CBCTR. The material provided will be mainly in the form of Tissue Microarrays that incorporate specimens from hundreds of cases on one or two slides. The CBCTR will, however, retain the ability to fill requests for sections of breast cancer material from a number of individual cases when the particular experiment can only be done with such material. 2. Continue the collection and updating of clinical and outcome data on each site's cases to assure the most accurate and contemporary material for each case. Such review will exploit automated sources of data but will also likely require review of a considerable number of primary sources: the medical records of these women. 3. Replenish the CBCTR for the cases that have been used by researchers. The CBCTR is currently a finite resource and is not being replenished with the addition of new cases. It has been designed to be used and, inevitably, depleted by its client cancer researchers. On the other hand, if funding becomes available and the National Cancer Institute decides to maintain a large and representative mixture of breast cancers in the CBCTR, each site can replenish the Resource by accrual of new cases diagnosed since 1993, when the original application was funded and after which few new cases were accrued.

描述（由申请人提供） 具体目标 从1993年开始，开发了合作的乳腺癌组织资源（CBCTR），以回应国家癌症研究所与美国的四个地点之间的合作一致性，以向生物医学研究界提供乳腺癌组织，以研究肿瘤预后的临床标记以及基于这些标记的有希望诊断测试的临床标志。当前的申请是对CBCTR重新申请的信函请求的响应，以便再进行三年的资金。 具体而言，这四个机构分别和一起 1。从CBCTR的文件继续向社区中的研究人员提供标本。所提供的材料将主要以组织微阵列的形式形式，这些阵列融合了一两个载玻片上数百个病例的标本。但是，CBCTR将保留从多个单个情况下只能使用此类材料进行特定实验的许多情况下填充乳腺癌材料部分的要求。 2。继续在每个站点的情况下收集和更新临床和结果数据，以确保每种情况最准确，最现代的材料。这种审查将利用自动数据来源，但也可能需要审查大量主要来源：这些妇女的病历。 3。为研究人员使用的病例补充CBCTR。 CBCTR目前是有限的资源，并未补充新案例。它被设计为使用，不可避免地被其客户癌研究人员耗尽。另一方面，如果资金可用，国家癌症研究所决定在CBCTR中维持乳腺癌的大量和代表性的混合物，则每个地点都可以通过自1993年自1993年诊断出的新案件的应计补充资源来补充资源，此后原始申请被资助，此后很少有新案例被纳入。