Cooperative Breast Cancer Tissue Resource (CBCTR)

合作乳腺癌组织资源 (CBCTR)

• 批准号: 7621116
• 负责人: Clara MILIKOWSKI
• 金额: $ 4.75万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7621116
• 关键词: Biomedical Research; Client; Clinical; Clinical Markers; Collection; Communities; Cooperative Breast Cancer Tissue Resource; Data; Data Sources; Diagnosis; Diagnostic tests; Doctor of Medicine; Evaluation; Evaluation Research; Funding; Hand; Individual; Institutes; Institution; Letters; Malignant Neoplasms; Medical Records; National Cancer Institute; Numbers; Outcome; Pathologic; Patients; Process; Request for Applications; Research Personnel; Resources; Site; Slide; Source; Specimen; Text; Tissue Microarray; Tissues; U-Series Cooperative Agreements; United States; Update; Woman; Work; base; cancer diagnosis; design; malignant breast neoplasm; member; outcome forecast; programs; repository; research study; response; tumor

Specific Aims The Cooperative Breast Cancer Tissue Resource (CBCTR) was developed, starting in 1993, in response to a cooperative agreement between the National Cancer Institute and four sites in the United States to provide breast cancer tissue to the biomedical research community for the study of clinical markers of tumor prognosis and the evaluation of promising diagnostic tests based on these markers. The current application is a response to a Letter Request for Applications for Recompetition of the CBCTR for a further three years of funding. Specifically, these four institutions individually and together will 1. Continue the provision of specimens to researchers in the community from the files of the CBCTR. The material provided will be mainly in the form of Tissue Microarrays that incorporate specimens from hundreds of cases on one or two slides. The CBCTR will, however, retain the ability to fill requests for sections of breast cancer material from a number of individual cases when the particular experiment can only be done with such material. 2. Continue the collection and updating of clinical and outcome data on each site's cases to assure the most accurate and contemporary material for each case. Such review will exploit automated sources of data but will also likely require review of a considerable number of primary sources: the medical records of these women. 3. Replenish the CBCTR for the cases that have been used by researchers. The CBCTR is currently a finite resource and is not being replenished with the addition of new cases. It has been designed to be used and, inevitably, depleted by its client cancer researchers. On the other hand, if funding becomes available and the National Cancer Institute decides to maintain a large and representative mixture of breast cancers in the CBCTR, each site can replenish the Resource by accrual of new cases diagnosed since 1993, when the original application was funded and after which few new cases were accrued.

具体目标 从1993年开始，开发了合作乳腺癌组织资源（CBCTR） 国家癌症研究所与美国四个地点之间的合作协议 生物医学研究界的乳腺癌组织研究肿瘤的临床标记 预后和基于这些标记的有希望的诊断测试的评估。当前的应用程序 是对CBCTR重新申请的申请信件的回应 资金。 具体而言，这四个机构分别和一起 1。从CBCTR的文件继续向社区中的研究人员提供标本。 所提供的材料将主要以融合标本的组织微阵列的形式 从一两个幻灯片上的数百个案例中。但是，CBCTR将保留填补的能力 当特定情况下，从许多个体情况下要求乳腺癌材料的部分 实验只能用这种材料进行。 2。继续收集和更新每个网站案件的临床和结果数据，以确保 每种情况下最准确和现代的材料。这种审查将利用自动资源 数据的数据，但也可能需要审查大量主要来源：医疗 这些妇女的记录。 3。为研究人员使用的病例补充CBCTR。 CBCTR当前是 有限资源，并未补充新案例。它被设计为 被其客户癌研究人员使用，不可避免地会耗尽。另一方面，如果有资金 可用，国家癌症研究所决定维持一个庞大的代表 CBCTR中乳腺癌的混合物，每个站点都可以通过新的新资源补充资源 自1993年以来诊断出原始申请以来被诊断出的病例，此后很少有新的 案件被计入。