Cooperative Breast Cancer Tissue Resource (CBCTR)

合作乳腺癌组织资源 (CBCTR)

• 批准号: 6795370
• 负责人: Clara MILIKOWSKI
• 金额: $ 11.69万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6795370
• 关键词: automated medical record system; breast neoplasms; cancer registry /resource; clinical research; cooperative study; data collection; human tissue; microarray technology; sample collection; tissue resource /registry

DESCRIPTION (provided by applicant) Specific Aims The Cooperative Breast Cancer Tissue Resource (CBCTR) was developed, starting in 1993, in response to a cooperative agreement between the National Cancer Institute and four sites in the United States to provide breast cancer tissue to the biomedical research community for the study of clinical markers of tumor prognosis and the evaluation of promising diagnostic tests based on these markers. The current application is a response to a Letter Request for Applications for Recompetition of the CBCTR for a further three years of funding. Specifically, these four institutions individually and together will 1. Continue the provision of specimens to researchers in the community from the files of the CBCTR. The material provided will be mainly in the form of Tissue Microarrays that incorporate specimens from hundreds of cases on one or two slides. The CBCTR will, however, retain the ability to fill requests for sections of breast cancer material from a number of individual cases when the particular experiment can only be done with such material. 2. Continue the collection and updating of clinical and outcome data on each site's cases to assure the most accurate and contemporary material for each case. Such review will exploit automated sources of data but will also likely require review of a considerable number of primary sources: the medical records of these women. 3. Replenish the CBCTR for the cases that have been used by researchers. The CBCTR is currently a finite resource and is not being replenished with the addition of new cases. It has been designed to be used and, inevitably, depleted by its client cancer researchers. On the other hand, if funding becomes available and the National Cancer Institute decides to maintain a large and representative mixture of breast cancers in the CBCTR, each site can replenish the Resource by accrual of new cases diagnosed since 1993, when the original application was funded and after which few new cases were accrued.

描述（由申请人提供） 具体目标 合作乳腺癌组织资源 (CBCTR) 于 1993 年开始开发，是为了响应国家癌症研究所与美国四个站点之间的合作协议，向生物医学研究界提供乳腺癌组织用于临床标志物的研究肿瘤预后和基于这些标志物的有前途的诊断测试的评估。当前的申请是对 CBCTR 申请再竞争三年资助信函的回应。 具体而言，这四个机构分别和共同将 1. 继续从 CBCTR 的档案中向社区研究人员提供标本。提供的材料将主要采用组织微阵列的形式，其中将来自数百个病例的标本合并在一张或两张载玻片上。然而，当特定实验只能用此类材料进行时，CBCTR 将保留满足对来自多个个体病例的乳腺癌材料切片的请求的能力。 2. 继续收集和更新每个站点病例的临床和结果数据，以确保每个病例都有最准确和最新的材料。此类审查将利用自动化数据源，但也可能需要审查大量主要来源：这些妇女的医疗记录。 3. 对研究者使用过的案例进行CBCTR的补充。 CBCTR 目前资源有限，不会随着新病例的增加而得到补充。它被设计为供其客户癌症研究人员使用，但不可避免地会被耗尽。另一方面，如果资金到位，并且国家癌症研究所决定在 CBCTR 中维持大量具有代表性的乳腺癌混合物，则每个站点都可以通过自 1993 年（最初的申请获得资助）以来诊断出的新病例来补充资源。此后几乎没有新增病例。