COOPERATIVE BREAST CANCER TISSUE REGISTRY

合作性乳腺癌组织登记处

基本信息

批准号：
6172229
负责人：
Clara MILIKOWSKI
金额：
$ 24.38万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-30 至 2003-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6172229
关键词：
automated medical record system biomarker breast neoplasms cancer registry /resource carcinoma clinical research female genetic markers hormone receptor human subject neoplasm /cancer classification /staging pathology tissue /cell preparation tissue resource /registry

项目摘要

DESCRIPTION: (Applicant's Description) The National Cancer Institute (NCI) has created a multi-institutional Cooperative Breast Cancer Tissue Resource (CBCTR) as a means of procuring and distributing archived paraffin embedded breast cancer tissues from patients with a known clinical outcome to support investigators validating potential prognostic and therapeutic markers. To date, this resource has catalogued data and tissues from 8,805 breast cancer patients. This competing continuation application describes the infrastructure created for the CBCTR since funding began in 1993. This includes the core personnel, computerized central and local databases, and tissue repositories. This application describes how registered tissues were categorized; the means of selecting, storing, and retrieving pertinent tissues; the coordination of clinical data and tissues; and the mechanism by which investigators gain access to the resource. How the tissues are prepared and distributed to researchers, as well as the quality control procedures that have been developed to achieve the goals of the resource are also outlined. The human subjects guidelines and medicolegal aspects bearing on the use of excess tissue for research are addressed. The University of Miami Jackson Memorial Hospital is an important component of this NCI-sponsored Cooperative Resource and pledges full cooperation to continue to help achieve its goals.

描述：（申请人的描述）美国国家癌症研究所 (NCI) 创建了一个多机构合作乳腺癌组织资源 (CBCTR) 作为获取手段并分发存档的石蜡包埋乳腺癌组织具有已知临床结果的患者支持研究人员验证潜在的预后和治疗标志物。迄今为止，该资源已对 8,805 名乳腺癌患者的数据和组织进行了编目。这竞争的延续应用程序描述了为以下目的创建的基础设施 CBCTR 自 1993 年开始资助以来。这包括核心人员、计算机化的中央和地方数据库以及组织储存库。这应用程序描述了注册组织的分类方式；的手段选择、储存和检索相关组织；的协调临床数据和组织；以及调查人员获得的机制访问资源。组织如何准备并分发给研究人员以及质量控制程序还概述了为实现资源目标而开发的资源。人类与过量使用有关的主题指南和法医学方面用于研究的组织已得到解决。迈阿密大学杰克逊纪念馆医院是 NCI 赞助的合作社的重要组成部分资源并承诺全力合作，继续帮助实现其目标。