COOPERATIVE BREAST CANCER TISSUE REGISTRY

合作性乳腺癌组织登记处

• 批准号: 6376045
• 负责人: Clara MILIKOWSKI
• 金额: $ 25.07万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376045
• 关键词: automated medical record system; biomarker; breast neoplasms; cancer registry /resource; carcinoma; clinical research; female; genetic markers; hormone receptor; human subject; neoplasm /cancer classification /staging; pathology; tissue /cell preparation; tissue resource /registry

DESCRIPTION: (Applicant's Description) The National Cancer Institute (NCI) has created a multi-institutional Cooperative Breast Cancer Tissue Resource (CBCTR) as a means of procuring and distributing archived paraffin embedded breast cancer tissues from patients with a known clinical outcome to support investigators validating potential prognostic and therapeutic markers. To date, this resource has catalogued data and tissues from 8,805 breast cancer patients. This competing continuation application describes the infrastructure created for the CBCTR since funding began in 1993. This includes the core personnel, computerized central and local databases, and tissue repositories. This application describes how registered tissues were categorized; the means of selecting, storing, and retrieving pertinent tissues; the coordination of clinical data and tissues; and the mechanism by which investigators gain access to the resource. How the tissues are prepared and distributed to researchers, as well as the quality control procedures that have been developed to achieve the goals of the resource are also outlined. The human subjects guidelines and medicolegal aspects bearing on the use of excess tissue for research are addressed. The University of Miami Jackson Memorial Hospital is an important component of this NCI-sponsored Cooperative Resource and pledges full cooperation to continue to help achieve its goals.

描述：（申请人的描述） 国家癌症研究所（NCI）创建了一个多机构 合作乳腺癌组织资源（CBCTR）作为采购手段 并从 具有已知临床结果的患者支持研究人员验证 潜在的预后和治疗标记。 迄今为止，此资源有 来自8,805名乳腺癌患者的数据和组织分类。 这 竞争连续应用程序描述了为 自1993年开始资金以来的CBCTR。这包括核心人员， 计算机化的中央和本地数据库以及组织存储库。 这 应用描述了注册组织是如何分类的；手段 选择，存储和检索相关组织；协调 临床数据和组织；以及研究人员获得的机制 访问资源。 如何准备组织并分布到 研究人员以及质量控制程序 还概述了为实现资源目标而开发的。 人类 主题指南和医疗方面涉及多余的使用 解决研究的组织。 迈阿密大学杰克逊纪念馆 医院是该NCI赞助的合作社的重要组成部分 资源并承诺完全合作，以继续帮助实现其目标。