Multiwavelength Optical Coherent Endoscopic Oximeter

多波长光学相干内窥镜血氧计

• 批准号: 6645625
• 负责人: PAUL SHNITSER
• 金额: $ 10万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645625
• 关键词: bioimaging /biomedical imaging; blood flow measurement; chick embryo; endoscopy; gastrointestinal circulation; gastrointestinal circulation disorder; gastrointestinal circulatory insufficiency; gastrointestinal disorder diagnosis; gastrointestinal imaging /visualization; hemoglobin; optical tomography; oximetry; phantom model; respiratory oxygenation

DESCRIPTION (provided by applicant): The limitations of endoscopy for early diagnosis of ischemic colitis and other gastrointestinal diseases can be overcome by introducing new functions into the conventional endoscope. These functions allow noninvasively measuring blood flow and blood-oxygenation. To realize these options Physical Optics Corporate on (POC) proposes an innovative multiwavelength, optical coherence endoscope oximeter (MENDOXIM). It will be capable of measuring tissue oxygenation for tissue cross section to a depth of 1-3 mm with lateral width about 1 mm while providing a high-resolution morphological image of the same area. In Phase I, POC will test the prototype MENDOXIM on tissue phantoms and demonstrate its performance on a chicken embryo in laboratory conditions. Upon evaluation of the test results, POC will optimize the MENDOXIM design for developing a Phase II working prototype ready for tests on animal models.

描述（由申请人提供）： 通过在传统内窥镜中引入新功能，可以克服内窥镜早期诊断缺血性结肠炎和其他胃肠道疾病的局限性。这些功能可以无创地测量血流和血氧。为了实现这些选择，Physical Optics Corporate (POC) 提出了一种创新的多波长光学相干内窥镜血氧计 (MENDOXIM)。它将能够测量深度为 1-3 毫米、横向宽度约为 1 毫米的组织横截面的组织氧合，同时提供同一区域的高分辨率形态学图像。在第一阶段，POC 将在组织模型上测试 MENDOXIM 原型，并在实验室条件下的鸡胚胎上展示其性能。在评估测试结果后，POC 将优化 MENDOXIM 设计，以开发第二阶段工作原型，准备在动物模型上进行测试。