Fast Acousto-Optic Tomography System

快速声光断层扫描系统

基本信息

批准号：
7909641
负责人：
PAUL SHNITSER
金额：
$ 99.85万
依托单位：
PHYSICAL OPTICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-26 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7909641
关键词：
Acoustics Affect Breast Breast Cancer Early Detection California Cancer Diagnostics Detection Development Diagnostic Early Diagnosis Engineering Female breast Focused Ultrasound Therapy Frequencies Goals Image Imaging Device Investigation Laboratories Life Light Location Malignant - descriptor Mammary Gland Parenchyma Mammography Maps Medical center Memory Needle biopsy procedure Neoplasms Normal tissue morphology Optics Organ Patients Phase Photons Predictive Value Probability Property Prostate Protocols documentation Research Resolution Screening procedure Signal Transduction Specificity Speed System Techniques Technology Testing Time Tissues Ultrasonography Variant cancer therapy design diffuse optical tomography heterodyning human subject improved innovation instrumentation malignant breast neoplasm operation prototype public health relevance time interval tomography tool tumor

项目摘要

DESCRIPTION (provided by applicant): To improve the probability of earlier breast cancer detection while reducing the number of unnecessary needle biopsies, Physical Optics Corporation proposes to develop a new Fast Acousto-Optic Tomography System (FAOTS) as an auxiliary tool for the conventional ultrasound breast examination that often follows a screening mammography. The innovative FAOTS will provide images with better contrast than sonography, because the optical properties of normal tissue and tissue with neoplasia differ much more than their acoustic properties. FAOTS will use a tightly focused ultrasound beam to shift the frequency of photons at a certain location in a tissue and detect them using a heterodyne technique utilizing a parallel signal acquisition by multiple photodetectors on a fast CMOS chip. The utilization of a high-speed (>4000 fps) CMOS camera with a large memory capacity enables signal detection in a short time interval, so speckle decorrelation in the live tissue will not affect system operation. In Phase I, POC experimentally demonstrated the capability of the laboratory prototype of obtaining high contrast signals with a speed exceeding the speckle decorrelation time. In Phase II, POC will design and fabricate an engineering FAOTS prototype and conduct a demonstration of its capability of mapping the optical properties of patient breast tissue at Harbor-UCLA Medical Center in Torrance, California. The fully developed FAOTS will provide a spatial resolution of ~0.4 mm, which is significantly better than Optical Diffuse Tomography (ODT). The FAOTS technology will enable positive predictive value (PPV) improvement in breast cancer diagnostics, with earlier detection of smaller tumors, thus enhancing patients' chances for long-time survival after cancer treatment. The successful demonstration of the FAOTS technology for mapping the optical properties of breast tissue will broaden the perspective for the extension of the FAOTS technology using multiple light wavelengths for improving image contrast. It will also facilitate development of special instrumentation for mapping the optical properties of other internal organs, and better diagnostics of tumors in these organs (e.g., prostate).

描述（由申请人提供）：为了提高早期乳腺癌检测的概率，同时减少不必要的穿刺活检数量，物理光学公司提议开发一种新的快速声光断层扫描系统（FAOTS）作为传统超声检查的辅助工具乳房检查通常在筛查性乳房X光检查之后进行。创新的FAOTS将提供比超声检查具有更好对比度的图像，因为正常组织和肿瘤组织的光学特性比它们的声学特性差异更大。 FAOTS 将使用紧密聚焦的超声波束来改变组织中特定位置处的光子频率，并使用外差技术来检测它们，该外差技术利用快速 CMOS 芯片上的多个光电探测器进行并行信号采集。利用具有大存储容量的高速（>4000 fps）CMOS相机可以在很短的时间间隔内进行信号检测，因此活体组织中的散斑去相关不会影响系统操作。在第一阶段，POC通过实验证明了实验室原型机以超过散斑去相关时间的速度获取高对比度信号的能力。在第二阶段，POC 将设计和制造一个工程性 FAOTS 原型，并在加利福尼亚州托伦斯市的 Harbour-UCLA 医疗中心展示其绘制患者乳腺组织光学特性的能力。完全开发的FAOTS将提供约0.4毫米的空间分辨率，这明显优于光学漫射断层扫描（ODT）。 FAOTS技术将提高乳腺癌诊断的阳性预测值（PPV），更早地检测出较小的肿瘤，从而提高患者在癌症治疗后长期生存的机会。用于绘制乳腺组织光学特性的FAOTS技术的成功演示将为使用多个光波长来提高图像对比度的FAOTS技术的扩展拓宽前景。它还将促进用于绘制其他内脏器官光学特性的特殊仪器的开发，以及更好地诊断这些器官（例如前列腺）中的肿瘤。