Fast Acousto-Optic Tomography System

快速声光断层扫描系统

• 批准号: 7909641
• 负责人: PAUL SHNITSER
• 金额: $ 99.85万
• 依托单位: PHYSICAL OPTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7909641
• 关键词: Acoustics; Affect; Breast; Breast Cancer Early Detection; California; Cancer Diagnostics; Detection; Development; Diagnostic; Early Diagnosis; Engineering; Female breast; Focused Ultrasound Therapy; Frequencies; Goals; Image; Imaging Device; Investigation; Laboratories; Life; Light; Location; Malignant - descriptor; Mammary Gland Parenchyma; Mammography; Maps; Medical center; Memory; Needle biopsy procedure; Neoplasms; Normal tissue morphology; Optics; Organ; Patients; Phase; Photons; Predictive Value; Probability; Property; Prostate; Protocols documentation; Research; Resolution; Screening procedure; Signal Transduction; Specificity; Speed; System; Techniques; Technology; Testing; Time; Tissues; Ultrasonography; Variant; cancer therapy; design; diffuse optical tomography; heterodyning; human subject; improved; innovation; instrumentation; malignant breast neoplasm; operation; prototype; public health relevance; time interval; tomography; tool; tumor

DESCRIPTION (provided by applicant): To improve the probability of earlier breast cancer detection while reducing the number of unnecessary needle biopsies, Physical Optics Corporation proposes to develop a new Fast Acousto-Optic Tomography System (FAOTS) as an auxiliary tool for the conventional ultrasound breast examination that often follows a screening mammography. The innovative FAOTS will provide images with better contrast than sonography, because the optical properties of normal tissue and tissue with neoplasia differ much more than their acoustic properties. FAOTS will use a tightly focused ultrasound beam to shift the frequency of photons at a certain location in a tissue and detect them using a heterodyne technique utilizing a parallel signal acquisition by multiple photodetectors on a fast CMOS chip. The utilization of a high-speed (>4000 fps) CMOS camera with a large memory capacity enables signal detection in a short time interval, so speckle decorrelation in the live tissue will not affect system operation. In Phase I, POC experimentally demonstrated the capability of the laboratory prototype of obtaining high contrast signals with a speed exceeding the speckle decorrelation time. In Phase II, POC will design and fabricate an engineering FAOTS prototype and conduct a demonstration of its capability of mapping the optical properties of patient breast tissue at Harbor-UCLA Medical Center in Torrance, California. The fully developed FAOTS will provide a spatial resolution of ~0.4 mm, which is significantly better than Optical Diffuse Tomography (ODT). The FAOTS technology will enable positive predictive value (PPV) improvement in breast cancer diagnostics, with earlier detection of smaller tumors, thus enhancing patients' chances for long-time survival after cancer treatment. The successful demonstration of the FAOTS technology for mapping the optical properties of breast tissue will broaden the perspective for the extension of the FAOTS technology using multiple light wavelengths for improving image contrast. It will also facilitate development of special instrumentation for mapping the optical properties of other internal organs, and better diagnostics of tumors in these organs (e.g., prostate).

描述（由申请人提供）：为了提高早期乳腺癌检测的可能性，同时减少了不必要的针头活检的数量，物理光学公司建议开发一种新的快速声学层析成像系统（FAOTS）作为辅助工具，作为常规超声检查，通常在筛查乳房疗程后进行筛查。创新的水元将提供比超声图更好的对比度，因为正常组织和组织具有肿瘤的光学特性远大于其声学特性。 FAOTS将使用紧密焦点的超声梁来移动组织中某个位置的光子频率，并使用杂作技术利用多个光电探测器在快速CMOS芯片上采集并行信号来检测它们。具有较大存储器容量的高速（> 4000 fps）CMOS摄像机的利用可以在短时间间隔内进行信号检测，因此实时组织中的Speckle DeRorlyation不会影响系统操作。在第一阶段，POC在实验上证明了实验室原型获得高对比度信号，速度超过斑点去相关时间。在第二阶段，POC将设计和制造工程水平原型，并演示其在加利福尼亚州托伦斯的Harbour-UCLA医疗中心绘制患者乳腺组织光学特性的能力。完全开发的水蛋白将提供〜0.4 mm的空间分辨率，其明显好于光学弥漫性层析成像（ODT）。 FAOTS技术将在乳腺癌诊断症中提高阳性预测价值（PPV），并较早发现较小的肿瘤，从而增加了患者在癌症治疗后长期生存的机会。绘制乳腺组织光学特性的FAOTS技术的成功演示将扩大使用多个光波长来扩展FAOTS技术的观点，以改善图像对比度。它还将促进开发特殊仪器，以绘制其他内部器官的光学特性，并更好地诊断这些器官中肿瘤（例如前列腺）。