2015 Stress Proteins in Growth, Development and Disease GRC

2015 生长、发育和疾病 GRC 中的应激蛋白

• 批准号: 8976890
• 负责人: Ursula H. Jakob
• 金额: $ 3.61万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8976890
• 关键词: Affect; Aging; Alzheimer' s Disease; Area; Biochemical; Biological Models; Biology; Cattle; Cell Proliferation; Cells; Cellular biology; Collaborations; Communities; Creutzfeldt-Jakob Syndrome; Data; Defect; Development; Devices; Dimensions; Disease; Ensure; Equilibrium; Europe; Evaluation; Faculty; Failure; Female; Fostering; Future; Gender; Gene Activation; Gene Expression; Generations; Genes; Growth and Development function; Health; Heat shock proteins; Homeostasis; Hour; Human; Huntington Disease; Industry; Infection; Inflammation; Intervention; Italy; Journals; Lead; Light; Link; Longevity; Maintenance; Metabolism; Michigan; Molecular; Molecular Chaperones; Names; Neurodegenerative Disorders; Organism; Oxidative Stress; Parkinson Disease; Participant; Physiological; Physiology; Plants; Play; Postdoctoral Fellow; Protein Conformation; Protein Dynamics; Protein-Folding Disease; Proteins; Proteome; Radiation; Regulation; Reporting; Request for Applications; Research; Research Personnel; Resort; Role; Schedule; Science; Scientist; Series; Shapes; Signal Transduction; Site; Sodium Chloride; Stress; Structure; System; Techniques; Temperature; Texas; Time; Ubiquitin; Underrepresented Minority; Universities; Water Stress; Woman; age related; base; biological adaptation to stress; career; collaborative environment; graduate student; human disease; improved; medical schools; meetings; microbial; multicatalytic endopeptidase complex; nervous system disorder; novel; polyglutamine; polypeptide; posters; preference; prion-based; programs; protein folding; protein function; public health relevance; research and development; stress protein; symposium; transcription factor

 DESCRIPTION (provided by applicant): The cellular proteome is constantly exposed to a wide variety of toxic stresses. These include external stresses, such as elevated temperatures, radiation damage and pharmacological agents as well as physiological stresses encountered during cellular proliferation, differentiation, inflammation and aging. In all organisms, inductionof the stress response is essential for the maintenance of protein homeostasis and modulation of the stress response plays a critical role in life-span regulation and aging-related diseases such as Alzheimer's, Parkinson's and Huntington's disease. The 2015 Gordon Conference on "Stress Proteins in Growth, Development & Disease" is shaping up to be one of the most exciting and important meetings in this research area. It will highlight the many cutting edge advances in the field, emphasizing a broad range of topics, including exciting developments related to stress sensing, signaling, and gene expression, diseases of protein folding and conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection and pathophysiological states, the cell biology of stress, and the roles of stress in aging. This conference, which is the eighth in this series, will be held July 5th-10th at the Il Ciocco Resort n Lucca, Italy. The chair of this meeting is Dr. Ursula Jakob (University of Michigan, Ann Arbor, MI) and the Vice Chair is Dr. Kevin Morano (UT Health Medical School in Houston, Texas). For the 2015 program, we have striven to improve our gender balance in the speaker representation, and of the 31 internationally recognized speakers who have accepted our invitation to give talks, 35% are women scientists. We also set aside time for 16 extended (i.e. 12 minutes) and 20 novel, two-minute poster talks at the end of the morning session to give investigators a chance to present key findings from their research and attract participants to their posters. Preference will be given to younger scientists and to those from under-represented groups. The meeting schedule is also prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be limited to 150 to facilitate effective interactions and discussions. The formal scientific program together with more informal round-table discussion will enhance the dissemination of new information and the formation of new collaborations, which are invaluable for deeper understanding of the versatile roles of stress proteins in human health, aging and disease.

 描述（由申请人提供）：细胞蛋白质组不断暴露于多种毒性应激，这些应激包括外部应激，例如高温、辐射损伤和药物，以及细胞增殖、分化、炎症和生长过程中遇到的生理应激。在所有生物体中，应激反应的诱导对于维持蛋白质稳态至关重要，应激反应的调节在寿命调节和衰老相关疾病（如阿尔茨海默病、帕金森病和亨廷顿病）中发挥着关键作用。 2015 年戈登会议“生长、发育和疾病中的应激蛋白”将成为该研究领域最令人兴奋和最重要的会议之一，它将突出该领域的许多前沿进展，强调广泛的研究成果。一系列主题，包括与应激传感、信号传导和基因表达相关的令人兴奋的进展、蛋白质折叠和构象疾病、应激基因在代谢、生长和发育中的作用、应激基因对感染和病理生理状态的调节、应激的细胞生物学，以及本次会议是该系列的第八次会议，将于 7 月 5 日至 10 日在意大利卢卡的 Il Ciocco 度假村举行，会议主席是 Ursula Jakob 博士（密歇根大学安）。密歇根州阿伯），副主席是 Kevin Morano 博士（德克萨斯州休斯顿 UT 健康医学院）。在 2015 年计划中，我们努力改善演讲者代表性以及 31 名演讲者的性别平衡。在接受我们邀请进行演讲的国际知名演讲者中，35% 是女性科学家。我们还在上午会议结束时预留了 16 场延长演讲（即 12 分钟）和 20 场新颖的两分钟海报演讲，以供研究人员使用。会议日程也将优先考虑年轻科学家和来自代表性不足的群体，以确保压力生物学和其他领域的新主题。模型系统是此外，会议出席人数将限制在 150 人以内，以促进有效的互动和讨论。 正式的科学计划加上更多的非正式圆桌讨论将加强新信息的传播和新合作的形成，这对于更深入地了解应激蛋白在人类健康、衰老和疾病中的多功能作用非常宝贵。