CONTROLLABLE MINIATURE CHOLANGIOSCOPE

可控微型胆管镜

• 批准号: 2539000
• 负责人: WILLIAM R. KRAUSE
• 金额: $ 8.97万
• 依托单位: FLEX TECHNOLOGY & BIOENGINEER CONSULTNTS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2539000
• 关键词: biliary tract disorder diagnosis; bioengineering /biomedical engineering; biomedical equipment development; cholangiography; clinical biomedical equipment; diagnosis design /evaluation

The aim of this proposal is to develop a small caliber cholangioscope that is torquable when passed through a standard duodenoscope to allow improved directional control of the cholangioscope within the biliary tree. Current small caliber cholangioscopes offer improved access to the biliary tree in comparison to larger "daughter" cholangioscopes. However, maneuverability of these smaller scopes has been limited. We hypothesize that construction of a new type of small cholangioscope using a flexible steel shaft will provide the ability to torque the scope to assist steering within the biliary tree. Our goal is to construct a flexible and torquable cholangioscope that remains within a suitable size range less than 3.1 mm) to allow passage through a therapeutic duodenoscope and to permit access to the biliary tree beyond the common hepatic duct bifurcation. The scope will have, in addition to torquability, a cable guided steering mechanism. The combination of its small caliber, torque-controlled steering and cable-guided steering will allow predictable access to second and possibly third level bile duct branches for inspection, biopsy and passage of guidewires or additional therapeutic instrumentation. PROPOSED COMMERCIAL APPLICATIONS: The total US market for endoscopes is approximately $30 million with small (less than 3 mm) scopes accounting for less than 1% of that market. With increased maneuverability to access the biliary tree and to provide direct biopsy, diagnosis of PSC using cholangioscopes will increase the demand for this product. Additional markets which will open up with the development of a more controllable miniature scope include arthroscopy of small joints.

该提案的目的是开发一种小口径 通过标准时可扭转的胆管镜 十二指肠镜可以改善对十二指肠镜的方向控制 胆管镜位于胆管树内。目前小口径 胆管镜可改善胆管树的通路 与较大的“子”胆管镜相比。然而， 这些较小范围的机动性受到限制。我们 假设构建新型小型胆管镜 使用柔性钢轴将提供扭转的能力 协助胆管树内转向的范围。我们的目标是 构建一个灵活且可扭转的胆管镜 在小于 3.1 毫米的合适尺寸范围内）以允许通过 通过治疗性十二指肠镜并允许进入 胆管树超出肝总管分叉处。 范围 除了扭矩能力外，还将具有电缆引导转向 机制。其小口径、扭矩控制的组合 转向和电缆引导转向将允许可预测的访问 用于检查的第二级和可能的第三级胆管分支， 活检和导丝通过或其他治疗 仪器仪表。 拟议的商业应用：美国整个市场 小型（小于 3 毫米）内窥镜的价值约为 3000 万美元 范围占该市场的不到1%。随着增加 可操作性地进入胆管树并提供直接的 活检，使用胆管镜诊断 PSC 将增加 对该产品的需求。将开放的其他市场 开发更可控的微型瞄准镜包括 小关节的关节镜检查。