MECHANICAL STRENGTH OF THE HEALED MENISCUS

愈合半月板的机械强度

• 批准号: 3157990
• 负责人: WILLIAM R. KRAUSE
• 金额: $ 10.73万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3157990
• 关键词: arthrodesis; articular cartilage; body physical activity; joint disorder; knee; occupational hazard; recreation; skeletal stress; sports medicine

The removal of the meniscus from the knee joint as a remedy for internal derangement is the third most common orthopaedic procedure performed. It is a common injury to anyone who kneels or squats during the course of his or her work and to athletically inclined people. In particular, it is a significant injury to miners and tradesmen (carpenters, plumbers, etc.) and to people actively engaged in sports. The effects of meniscectomy have been shown to significantly increase the possibility of joint degeneration. In order to restore the normal load transmission and energy absorbing capabilities of the meniscus, it has been proposed that the torn meniscus be surgically repaired and not removed. Therefore, it is the objective of this study to determine the mechanical properties of the repaired and healed meniscus. The strength of the healed meniscus will be evaluated with respect to 1) the time of injury to the time of repair, 2) the time the meniscus is allowed to heal, and 3) its morphological composition. In order to make this study clinically relevant, bovine menisci, of approximately human dimensions, and canine meniscus will be transected arthroscopically. At specific time intervals after the simulated injury, the meniscus will be arthroscopically repaired and allowed to heal. This is relevant to atheletes who injure their meniscus and are operated on a few days later. The repaired meniscus will be removed and mechanical and histological evaluations performed. Statistical analysis will be performed to determine the differences and significance of each time variable on the healed meniscus compared to control, normal tissue. The significance of this research is that it will make possible a quantitative determination of the feasibility of repairing torn menisci. The immediate clinical relevancy of this research is that it will provide new information to the orthopaedic surgeon for the treatment and management of meniscal injuries. The anticipated long term benefits will be a reduction in the incidence of degenerative joint disease and a parallal reduction in the number of work days lost to the complications of degenerative joint diseases.

从膝关节去除半月板作为内部治疗的补救措施 紊乱是第三种最常见的骨科手术。 它 对于跪着或蹲着的人来说，这是一种常见的伤害 或她的工作以及有运动倾向的人。 特别是，它是一个 对矿工和商人（木匠、水管工等）造成严重伤害，以及 积极从事体育运动的人们。 半月板切除术的效果有 已被证明会显着增加关节退化的可能性。 为了恢复正常的载荷传递和能量吸收 半月板的功能，有人提出半月板撕裂 通过手术修复而不是移除。 因此，其目标是 这项研究旨在确定修复后的机械性能 半月板愈合了。 将评估愈合的半月板的强度 1) 受伤时间到修复时间，2) 时间 允许半月板愈合，以及 3) 其形态组成。 为了使这项研究具有临床意义，牛半月板 大约人类尺寸，犬半月板将被横断 关节镜下。 在模拟伤害后的特定时间间隔， 半月板将通过关节镜修复并愈合。 这 与半月板受伤并接受手术的运动员有关 几天后。 修复后的半月板将被移除并进行机械和 进行组织学评估。 将进行统计分析 确定每个时间变量的差异和显着性 与对照正常组织相比，愈合的半月板。 这项研究的意义在于它将使 定量测定修复撕裂半月板的可行性。 这项研究的直接临床意义在于它将提供 为骨科医生提供治疗和管理的新信息 半月板损伤。 预期的长期效益将是 减少退行性关节疾病的发生率和平行 减少因并发症而损失的工作日数 退行性关节疾病。