MECHANICAL STRENGTH OF THE HEALED MENISCUS

愈合半月板的机械强度

• 批准号: 3154636
• 负责人: WILLIAM R. KRAUSE
• 金额: $ 14.62万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3154636
• 关键词: arthrodesis; articular cartilage; body physical activity; joint disorder; knee; occupational hazard; recreation; skeletal stress; sports medicine

The removal of the meniscus from the knee joint as a remedy for internal derangement is the third most common orthopaedic procedure performed. It is a common injury to anyone who kneels or squats during the course of his or her work and to athletically inclined people. In particular, it is a significant injury to miners and tradesmen (carpenters, plumbers, etc.) and to people actively engaged in sports. The effects of meniscectomy have been shown to significantly increase the possibility of joint degeneration. In order to restore the normal load transmission and energy absorbing capabilities of the meniscus, it has been proposed that the torn meniscus be surgically repaired and not removed. Therefore, it is the objective of this study to determine the mechanical properties of the repaired and healed meniscus. The strength of the healed meniscus will be evaluated with respect to 1) the time of injury to the time of repair, 2) the time the meniscus is allowed to heal, and 3) its morphological composition. In order to make this study clinically relevant, bovine menisci, of approximately human dimensions, and canine meniscus will be transected arthroscopically. At specific time intervals after the simulated injury, the meniscus will be arthroscopically repaired and allowed to heal. This is relevant to atheletes who injure their meniscus and are operated on a few days later. The repaired meniscus will be removed and mechanical and histological evaluations performed. Statistical analysis will be performed to determine the differences and significance of each time variable on the healed meniscus compared to control, normal tissue. The significance of this research is that it will make possible a quantitative determination of the feasibility of repairing torn menisci. The immediate clinical relevancy of this research is that it will provide new information to the orthopaedic surgeon for the treatment and management of meniscal injuries. The anticipated long term benefits will be a reduction in the incidence of degenerative joint disease and a parallal reduction in the number of work days lost to the complications of degenerative joint diseases.

从膝盖关节中除去弯月面，以作为内部的补救措施 毁灭是执行的第三大常见骨科手术。 它 对于任何在他的过程中跪下或蹲下的人都是常见的伤害 或她的工作和运动倾向的人。 特别是 对矿工和商人（木匠，水管工等）的重大伤害 给积极从事运动的人们。 半月切除术的影响 已显示可显着增加关节变性的可能性。 为了恢复正常的负载传输和吸收能量 弯弯具的能力，有人提出了撕裂的半月板 可以手术修复并没有去除。 因此，这是 这项研究确定修复的机械性能和 治愈半月板。 将评估被治愈的半月板的强度 关于1）修复时间受伤时间，2）时间 拟弯室被允许愈合，3）其形态组成。 为了使这项研究在临床上相关，牛半月板 大约人类的尺寸和犬弯弯 关节镜。 在模拟受伤后的特定时间间隔， 半月板将进行关节镜修理并允许愈合。 这 与伤害弯月板并在某人上操作的小腿有关 几天后。 修复后的弯板将被拆除和机械，并 进行组织学评估。 统计分析将进行 确定每个时间变量在 与对照，正常组织相比，治愈的半月板愈合。 这项研究的意义在于，它将成为可能 定量确定修复撕裂的半月板的可行性。 这项研究的直接临床相关性是它将提供 给骨科医生的新信息以进行治疗和管理 半月板伤害。 预期的长期利益将是 退化关节疾病的发病率降低和差异 减少因并发症而损失的工作日数 退化性关节疾病。