Coaxial Everting Membrane Catheter Bronchoalveolar Lavag

同轴外翻膜导管支气管肺泡灌洗

• 批准号: 7162057
• 负责人: WILLIAM R. KRAUSE
• 金额: $ 19.79万
• 依托单位: BIOENGINEERING CONSULTANTS, LTD
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162057
• 关键词: artificial respiration; bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; computer program /software; critical care; diagnostic catheterization; diagnostic respiratory lavage; evaluation /testing; iatrogenic disease; intensive care; lung lavage; mechanical stress; medical complication; nosocomial infections; phantom model; pneumonia; respirators

DESCRIPTION (provided by applicant): Project Summary/Abstract: Ventilator-Associated Pneumonia (VAP) is pneumonia that develops in a mechanically ventilated patient later than 48 hours after intubation. The longer a patient is intubated, the greater the chance that pneumonia will develop. Pneumonia is the second most common nosocomial infection in critically ill patients, impacting 27% of all critically ill patients and is the leading cause of death from hospital-acquired (nosocomial) infections. 86% of nosocomial pneumonias (NP) are associated with mechanical ventilation and are termed ventilator associated pneumonia. Between 250,000 and 300,000 cases per year occur in the United States, alone which is an incidence rate of 5-10 cases per 1,000 hospital admissions. An important diagnostic procedure is a culture of the sputum or lung aspirate for accurate diagnosis and therapeutic evaluation of the cause of the pneumonia. However, sputum (lung, trachea or oropharyngeal secretions) is often contaminated by saliva, oropharyngeal organisms and squamous cells that are deposited on the catheter during passage through the mouth and trachea. There are no commercially available catheter systems that allow for the collection of uncontaminated sputum samples for the diagnosis of pneumonia. The total commercial market for this type of device is approximately 250,000 units at a retail cost of $100 per device. The specific aim of this proposal is to design, prototype and evaluate an innovative coaxial everting membrane catheter for bronchoalveolar lavage (referred to as the CEMBAL catheter and brush) for accurate sputum collection for diagnosis of pneumonia. It is our hypothesis that the CEMBAL catheter system will allow the quick and easy collection of uncontaminated sputum for better management of the VAP patient. We propose to compare the CEMBAL catheter with the CombiCath(r) and a standard suction catheter in a bench-top model to demonstrate the ability of the catheter to retrieve uncontaminated samples. Project Narrative: Ventilator-Associated Pneumonia (VAP) is the second most common nosocomial infection in critically ill patients, impacting 27% of all critically ill patients and is the leading cause of death from hospital-acquired (nosocomial) infections. The proposed device will provide for the uncontaminated sampling of the lower lung aspirate for a more accurate diagnosis of the organism causing the pneumonia.

描述（由申请人提供）： 项目摘要/摘要：呼吸机相关肺炎 (VAP) 是机械通气患者在插管后 48 小时内发生的肺炎。患者插管的时间越长，发生肺炎的机会就越大。肺炎是危重患者中第二常见的医院感染，影响所有危重患者的 27%，也是医院获得性（院内）感染死亡的主要原因。 86% 的院内肺炎 (NP) 与机械通气相关，被称为呼吸机相关性肺炎。仅在美国，每年就有 250,000 至 300,000 例病例发生，即每 1,000 名住院患者中就有 5-10 例病例。一个重要的诊断程序是痰培养或肺吸出物培养，以准确诊断肺炎的病因并进行治疗评估。然而，痰液（肺、气管或口咽分泌物）经常被唾液、口咽生物和鳞状细胞污染，这些细菌在通过口腔和气管时沉积在导管上。目前还没有市售的导管系统可以收集未受污染的痰样本来诊断肺炎。此类设备的商业市场总量约为 250,000 台，每台设备的零售成本为 100 美元。该提案的具体目的是设计、原型设计和评估一种用于支气管肺泡灌洗的创新同轴外翻膜导管（称为 CEMBAL 导管和刷），以准确收集痰液以诊断肺炎。我们假设 CEMBAL 导管系统将允许快速、轻松地收集未受污染的痰液，以便更好地管理 VAP 患者。我们建议在台式模型中将 CEMBAL 导管与 CombiCath(r) 和标准抽吸导管进行比较，以证明导管回收未污染样本的能力。项目叙述：呼吸机相关肺炎 (VAP) 是危重患者中第二常见的院内感染，影响所有危重患者的 27%，也是医院获得性（院内）感染死亡的主要原因。所提出的装置将提供下肺抽吸物的未污染采样，以便更准确地诊断引起肺炎的微生物。