Coaxial Everting Membrane Catheter Bronchoalveolar Lavag

同轴外翻膜导管支气管肺泡灌洗

• 批准号: 7162057
• 负责人: WILLIAM R. KRAUSE
• 金额: $ 19.79万
• 依托单位: BIOENGINEERING CONSULTANTS, LTD
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162057
• 关键词: artificial respiration; bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; computer program /software; critical care; diagnostic catheterization; diagnostic respiratory lavage; evaluation /testing; iatrogenic disease; intensive care; lung lavage; mechanical stress; medical complication; nosocomial infections; phantom model; pneumonia; respirators

DESCRIPTION (provided by applicant): Project Summary/Abstract: Ventilator-Associated Pneumonia (VAP) is pneumonia that develops in a mechanically ventilated patient later than 48 hours after intubation. The longer a patient is intubated, the greater the chance that pneumonia will develop. Pneumonia is the second most common nosocomial infection in critically ill patients, impacting 27% of all critically ill patients and is the leading cause of death from hospital-acquired (nosocomial) infections. 86% of nosocomial pneumonias (NP) are associated with mechanical ventilation and are termed ventilator associated pneumonia. Between 250,000 and 300,000 cases per year occur in the United States, alone which is an incidence rate of 5-10 cases per 1,000 hospital admissions. An important diagnostic procedure is a culture of the sputum or lung aspirate for accurate diagnosis and therapeutic evaluation of the cause of the pneumonia. However, sputum (lung, trachea or oropharyngeal secretions) is often contaminated by saliva, oropharyngeal organisms and squamous cells that are deposited on the catheter during passage through the mouth and trachea. There are no commercially available catheter systems that allow for the collection of uncontaminated sputum samples for the diagnosis of pneumonia. The total commercial market for this type of device is approximately 250,000 units at a retail cost of $100 per device. The specific aim of this proposal is to design, prototype and evaluate an innovative coaxial everting membrane catheter for bronchoalveolar lavage (referred to as the CEMBAL catheter and brush) for accurate sputum collection for diagnosis of pneumonia. It is our hypothesis that the CEMBAL catheter system will allow the quick and easy collection of uncontaminated sputum for better management of the VAP patient. We propose to compare the CEMBAL catheter with the CombiCath(r) and a standard suction catheter in a bench-top model to demonstrate the ability of the catheter to retrieve uncontaminated samples. Project Narrative: Ventilator-Associated Pneumonia (VAP) is the second most common nosocomial infection in critically ill patients, impacting 27% of all critically ill patients and is the leading cause of death from hospital-acquired (nosocomial) infections. The proposed device will provide for the uncontaminated sampling of the lower lung aspirate for a more accurate diagnosis of the organism causing the pneumonia.

描述（由申请人提供）：项目摘要/摘要：呼吸机相关的肺炎（VAP）是肺炎，在插管后48小时后，机械通气患者在机械通风的患者中发育。患者插管的时间越长，肺炎发育的可能性就越大。肺炎是重症患者中第二大常见的医院感染，影响了所有重症患者的27％，并且是医院经验性（医院）感染的主要死亡原因。 86％的医院肺炎（NP）与机械通气有关，称为呼吸机相关的肺炎。每年在美国发生25万至300,000例，仅在美国，每1,000例医院入院的发病率为5-10例。一个重要的诊断程序是痰液或肺部抽吸的培养物，以准确诊断和治疗肺炎原因。然而，痰液（肺，气管或口咽分泌物）通常受到唾液，口咽生物和鳞状细胞的污染，这些细胞和鳞状细胞在通过口腔和气管过程中沉积在导管上。没有商业可用的导管系统可以收集未污染的痰液样品来诊断肺炎。此类设备的总商业市场约为250,000台，零售价为每台设备100美元。该提案的具体目的是设计，原型和评估用于支气管肺泡灌洗的创新同轴膜导管（称为墓地导管和刷子），以精确的痰液收集以诊断肺炎。我们的假设是，Cembal导管系统将允许快速简便地收集未污染的痰，以更好地管理VAP患者。我们建议将Cembal导管与卧台模型中的cembal导管（R）和标准吸管导管进行比较，以证明导管检索未污染的样品的能力。项目叙述：与呼吸机相关的肺炎（VAP）是重症患者中第二常见的医院感染，影响了所有重症患者的27％，并且是医院疗法（医院）感染的主要死亡原因。所提出的装置将提供对下肺抽吸物的未污染采样，以更准确地诊断引起肺炎的生物体。