RFA-PS-23-001 - Project PrOVIDE: PrEP Optimization Via Implementation, Dissemination, and Evaluation

RFA-PS-23-001 - 项目提供：通过实施、传播和评估优化 PrEP

• 批准号: 10820208
• 负责人: Amy Kristen Johnson
• 金额: $ 200万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2027-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10820208
• 关键词: RFA; PS; 23; 001; Project

PROJECT SUMMARY Significant disparities in pre-exposure prophylaxis (PrEP) for HIV prevention exist in the U.S. with cisgender women making up a disproportionately low percentage of PrEP users compared to men. 60% of new HIV diagnoses among women are among Black cisgender women. Challenges exist at each step of the PrEP care continuum, including difficulty identifying Black cisgender women at highest risk for HIV who are most likely to benefit from PrEP, women’s own low self-perception of HIV risk, low levels of PrEP knowledge, and barriers to PrEP initiation and persistence. While there has been growing knowledge of interventions to increase PrEP use among men who have sex with men and transgender women, much less is known about successful implementation strategies to increase uptake and support PrEP persistence among Black cisgender women. Our team’s preliminary mixed methods work identified PrEP implementation strategies for Black cisgender women consisting of: routine PrEP education for patients, standardized provider training, electronic medical record tools, PrEP navigation, clinical champions, and mHealth tools. We propose to adapt, implement, and evaluate the impact of these strategies to improve PrEP care continuum outcomes for Black cisgender women across six counties in the U.S. using implementation science research methods. PrEP implementation planning will guide strategy selection and identification of new implementation strategies. Our team proposes the following aims: AIM 1: Identify, select, and adapt implementation strategies for engaging Black women in the PrEP care continuum in six clinic settings in EHE priority areas (midwest, north, south). AIM 2: Determine the effectiveness of PrOVIDE implementation strategies on PrEP uptake among Black cisgender women across six clinic sites via a hybrid type II study design. AIM 3: Assess and document implementation outcomes and report on key barriers and facilitators related to successful implementation of the implementation strategies using the RE-AIM framework.

项目概要 美国的顺性别人群在预防艾滋病毒的暴露前预防 (PrEP) 方面存在显着差异 与男性新感染艾滋病毒的 60% 相比，女性在 PrEP 使用者中所占比例过低。 PrEP 护理的每一步都存在挑战。 连续体，包括难以识别感染艾滋病毒风险最高的黑人顺性别女性，她们最有可能 PrEP 的受益、女性自身对 HIV 风险的低自我认知、PrEP 知识水平低以及 尽管人们对增加 PrEP 的干预措施的了解不断增加。 男男性行为者和变性女性中的使用，对于成功的了解更少 实施战略，以提高黑人顺性别女性的接受率并支持其坚持不懈。 我们团队的初步混合方法工作确定了黑人顺性别者的 PrEP 实施策略 女性包括：对患者进行常规 PrEP 教育、标准化提供者培训、电子医疗 我们建议调整、实施和使用记录工具、PrEP 导航、临床冠军和移动医疗工具。 评估这些策略对改善黑人顺性别女性 PrEP 护理连续结果的影响 使用科学研究方法在美国六个县实施 PrEP 实施规划。 将指导战略选择和新实施战略的确定。我们的团队提出以下建议。 目标：目标 1：确定、选择和调整实施策略，让黑人妇女参与 PrEP 护理 在 EHE 优先区域（中西部、北部、南部）的六个诊所环境中进行连续统一目标 2：确定有效性。 通过实施，六个诊所站点的黑人顺性别女性采用 PrEP 的 ProVIDE 策略 混合型 II 研究设计 AIM 3：评估和记录实施结果并报告主要障碍。 以及与使用 RE-AIM 成功实施实施策略相关的促进者 框架。