Midwest TXTXT: Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence

中西部 TXTXT：扩大循证干预措施以促进艾滋病毒药物依从性

• 批准号: 10285610
• 负责人: Amy Kristen Johnson
• 金额: $ 35万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285610
• 关键词: Midwest; TXTXT; Scale; up; Evidence

PROJECT SUMMARY ABSTRACT In this application, we propose to scale up an Evidence-Based Intervention- TXTXT- by creating a regional hub in the Midwest to coordinate broad dissemination, and to greatly increase reach and impact. We will evaluate the implementation of the EBI scale up via a hybrid type II design to inform the broad dissemination of a region-based implementation model and will elaborate a sustainability plan for TXTXT to inform wide scale dissemination and rapid scale up to additional US regions. Specific Aims: 1. Determine the real-world efficacy of a regional scale up of an EBI- TXTXT- on our primary and secondary outcomes: adherence, viral load suppression, and retention in HIV care, respectively, among poorly adherent racial/ethnic minority YLH, ages 16-35 at 3-and 6-month follow-up. 2. Apply the Consolidated Framework for Implementation Research (CFIR) to describe the implementation process and identify barriers and facilitators needed to be addressed; and measure implementation outcomes of the TXTXT intervention using the RE-AIM framework (Reach, Efficacy, Adoption, Implementation, Maintenance). Dr. Johnson is an ideal candidate for an HIV-focused Implementation Science mentorship award. She is a trained Infectious Disease Epidemiologist with initial certification in Implementation Science approaches and methods (not yet applied). As an early career HIV prevention scientist, she has a breath of experience that stems from community-engaged research which includes basic science, including surveillance and epidemiology as well as intervention development and capacity development initiatives. The next logical step is to gain skills in systems-level implementation science and sustainability planning to inform broad dissemination of evidence-based interventions. This study combines behavioral and social science, implementation science, and information dissemination towards the ultimate goal of public health impact. Medication adherence is a key driver of viral suppression and this regional TXTXT initiative, with a longer-term objective of national dissemination and focused on patients at most risk of virologic failure will directly address local, regional and national goals to End the Epidemic by 2030.

项目概要摘要 在此应用中，我们建议通过创建区域中心来扩大循证干预（TXXTT） 在中西部协调广泛的传播，并大大增加影响力和影响力。我们将评估 通过混合 II 型设计扩大 EBI 的实施，为广泛传播 基于区域的实施模型，并将为 TXTXT 制定可持续发展计划，以告知广泛的 传播并迅速扩展到美国其他地区。 具体目标： 1. 确定 EBI-TXXTT- 的区域规模扩大对我们的主要和 次要结局：分别为依从性、病毒载量抑制和艾滋病毒护理保留率 依从性差的少数民族 YLH，3 个月和 6 个月随访时年龄为 16-35 岁。 2. 应用实施研究综合框架（CFIR）来描述实施情况 处理并确定需要解决的障碍和促进因素；并衡量实施情况 使用 RE-AIM 框架进行 TXTXT 干预的结果（覆盖范围、功效、采用、 实施、维护）。 约翰逊博士是获得以艾滋病毒为重点的实施科学指导奖的理想候选人。她是一个 训练有素的传染病流行病学家，拥有实施科学方法的初步认证和 方法（尚未应用）。作为一名职业生涯早期的艾滋病毒预防科学家，她拥有丰富的经验 源于社区参与的研究，其中包括基础科学，包括监测和 流行病学以及干预措施发展和能力发展举措。下一个逻辑步骤是 获得系统级实施科学和可持续性规划方面的技能，为广泛传播提供信息 循证干预措施。这项研究结合了行为科学和社会科学、实施科学、 和信息传播以实现公共卫生影响的最终目标。坚持用药是关键 病毒抑制和这一区域 TXTXT 倡议的驱动力，其长期目标是国家 传播并重点关注最有病毒学失败风险的患者将直接解决地方、区域和 到2030年结束流行病的国家目标。