Midwest TXTXT: Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence

中西部 TXTXT：扩大循证干预措施以促进艾滋病毒药物依从性

• 批准号: 10625405
• 负责人: Amy Kristen Johnson
• 金额: $ 35万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10625405
• 关键词: Midwest; TXTXT; Scale; up; Evidence; Midwest; TXTXT; Scale; up; Evidence

PROJECT SUMMARY ABSTRACT In this application, we propose to scale up an Evidence-Based Intervention- TXTXT- by creating a regional hub in the Midwest to coordinate broad dissemination, and to greatly increase reach and impact. We will evaluate the implementation of the EBI scale up via a hybrid type II design to inform the broad dissemination of a region-based implementation model and will elaborate a sustainability plan for TXTXT to inform wide scale dissemination and rapid scale up to additional US regions. Specific Aims: 1. Determine the real-world efficacy of a regional scale up of an EBI- TXTXT- on our primary and secondary outcomes: adherence, viral load suppression, and retention in HIV care, respectively, among poorly adherent racial/ethnic minority YLH, ages 16-35 at 3-and 6-month follow-up. 2. Apply the Consolidated Framework for Implementation Research (CFIR) to describe the implementation process and identify barriers and facilitators needed to be addressed; and measure implementation outcomes of the TXTXT intervention using the RE-AIM framework (Reach, Efficacy, Adoption, Implementation, Maintenance). Dr. Johnson is an ideal candidate for an HIV-focused Implementation Science mentorship award. She is a trained Infectious Disease Epidemiologist with initial certification in Implementation Science approaches and methods (not yet applied). As an early career HIV prevention scientist, she has a breath of experience that stems from community-engaged research which includes basic science, including surveillance and epidemiology as well as intervention development and capacity development initiatives. The next logical step is to gain skills in systems-level implementation science and sustainability planning to inform broad dissemination of evidence-based interventions. This study combines behavioral and social science, implementation science, and information dissemination towards the ultimate goal of public health impact. Medication adherence is a key driver of viral suppression and this regional TXTXT initiative, with a longer-term objective of national dissemination and focused on patients at most risk of virologic failure will directly address local, regional and national goals to End the Epidemic by 2030.

项目摘要摘要 在此应用中，我们建议通过创建区域枢纽来扩展基于证据的干预txtx- 在中西部协调广泛的传播，并大大增加覆盖范围和影响。我们将评估 通过混合II型设计实施EBI规模，以告知广泛的传播 基于区域的实施模型，并将阐明TXTXT的可持续性计划，以告知大规模 传播和快速扩展到其他美国地区。 具体目的： 1。确定eBi-txtxt的区域尺度的现实世界疗效 - 次要结果：分别依从性，病毒负荷抑制和在艾滋病毒护理中保留 在3岁和6个月的随访中，依从性的种族/少数民族少数族裔少数民族，年龄在16-35岁。 2。将合并框架应用于实施研究（CFIR）来描述实施 处理并确定需要解决的障碍和促进者；并衡量实施 使用RE-AIM框架（触及，功效，采用， 实施，维护）。 约翰逊博士是以HIV为重点的实施科学指导奖的理想候选人。她是一个 受过训练的传染病流行病学家，具有实施科学方法的初步认证和 方法（尚未应用）。作为早期职业艾滋病毒预防科学家，她有一段经验 来自社区参与的研究，包括基础科学，包括监视和 流行病学以及干预发展和能力发展计划。下一个逻辑步骤是 获得系统级实施科学和可持续性计划的技能，以告知广泛传播 基于证据的干预措施。这项研究结合了行为和社会科学，实施科学， 和信息传播朝着公共卫生影响的最终目标。药物依从性是关键 病毒抑制和该区域TXTXT倡议的驱动力，其长期目标 传播并关注以病毒衰竭风险的风险的患者，将直接解决地方，区域和 到2030年结束流行病的国家目标。