Genes underlying reproductive behavior physiology and neuronal development

生殖行为生理学和神经元发育的基因

• 批准号: 10797431
• 负责人: MICHELLE N ARBEITMAN
• 金额: $ 0.82万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-06 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10797431
• 关键词: Address; Adult; Behavior; Behavioral; Biological Models; Brain; Complex; Development; Disease; Drosophila genus; Funding; Genes; Genomics; Health; Human; Laboratories; Mental Health; Mental disorders; Microscopy; Modeling; Molecular; Molecular Genetics; Mutation; National Institute of General Medical Sciences; Nervous System; Neurons; Organism; Physiology; Process; Proteins; Proteomics; Reproductive Behavior; Research; Role; Structure; System; Work; experience; gene function; gene regulatory network; insight; neural circuit; neuron development; programs; sex; tool; transcription factor

Project Summary/Abstract To understand mental health and disease, we need to understand the function of the brain at the level of genes, gene regulatory networks, neurons, circuit structure, and physiology. Drosophila has emerged as one of the most powerful model systems for these questions, given the range of tools and the tractability of analyzing complex behaviors at all these levels. This proposal seeks to understand Drosophila reproductive behaviors. One reason Drosophila is such a powerful system is that the sex-specific master regulatory transcription factors that direct reproductive behaviors are known. This has provided a powerful molecular inroad into identifying and manipulating the neurons that underlie these behaviors. These tools can also be used to perform neuron-specific mutational studies to discover the functions of genes that direct behaviors, which leverages one of the biggest strengths of the Drosophila model system. In addition, this system affords an unparalleled model to both examine the sex-specific development of these neurons and how they are modified by adult experiences. Research using the Drosophila model has continued to uncover biologically important processes that have informed on human health and disease, including studies of the nervous system and behavior. The work will build off of my laboratories 15-year NIGMS funded research program. We will continue to address these behavioral questions using cutting-edge molecular-genetic, genomic, proteomic, behavioral and microscopy tools to gain insights into complex behaviors.

项目概要/摘要 为了了解心理健康和疾病，我们需要在基因水平上了解大脑的功能， 基因调控网络、神经元、电路结构和生理学。果蝇已成为其中之一 考虑到工具的范围和分析的易处理性，解决这些问题的最强大的模型系统 所有这些层面的复杂行为。该提案旨在了解果蝇的繁殖行为。 果蝇如此强大的系统的一个原因是，性别特异性主调控转录因子 直接的繁殖行为是已知的。这为识别和鉴定提供了强有力的分子途径 操纵这些行为背后的神经元。这些工具还可用于执行神经元特异性 突变研究发现指导行为的基因功能，它利用了最大的基因之一 果蝇模型系统的优势。此外，该系统提供了一个无与伦比的模型来检查 这些神经元的性别特异性发育以及它们如何被成人经历所改变。研究使用 果蝇模型继续揭示了对人类有影响的生物学重要过程 健康和疾病，包括神经系统和行为的研究。这项工作将建立在我的 实验室 15 年 NIGMS 资助的研究计划。我们将继续解决这些行为问题 使用尖端的分子遗传学、基因组、蛋白质组、行为和显微镜工具来深入了解 复杂的行为。