Genes underlying reproductive behavior physiology and neuronal development

生殖行为生理学和神经元发育的基因

• 批准号: 10405677
• 负责人: MICHELLE N ARBEITMAN
• 金额: $ 72.85万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-06 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10405677
• 关键词: Address; Adult; Behavior; Behavioral; Biological Models; Brain; Complex; Development; Disease; Drosophila genus; Funding; Gene Proteins; Genes; Genomics; Health; Human; Laboratories; Mental Health; Mental disorders; Microscopy; Modeling; Molecular; Molecular Genetics; Mutation; National Institute of General Medical Sciences; Nervous system structure; Neurons; Organism; Physiology; Process; Proteomics; Reproductive Behavior; Research; Role; Structure; System; Work; experience; gene function; gene regulatory network; insight; neural circuit; neuron development; programs; sex; tool; transcription factor

Project Summary/Abstract To understand mental health and disease, we need to understand the function of the brain at the level of genes, gene regulatory networks, neurons, circuit structure, and physiology. Drosophila has emerged as one of the most powerful model systems for these questions, given the range of tools and the tractability of analyzing complex behaviors at all these levels. This proposal seeks to understand Drosophila reproductive behaviors. One reason Drosophila is such a powerful system is that the sex- specific master regulatory transcription factors that direct reproductive behaviors are known. This has provided a powerful molecular inroad into identifying and manipulating the neurons that underlie these behaviors. These tools can also be used to perform neuron-specific mutational studies to discover the functions of genes that direct behaviors, which leverages one of the biggest strengths of the Drosophila model system. In addition, this system affords an unparalleled model to both examine the sex-specific development of these neurons and how they are modified by adult experiences. Research using the Drosophila model has continued to uncover biologically important processes that have informed on human health and disease, including studies of the nervous system and behavior. The work will build off of my laboratories 15-year NIGMS funded research program. We will continue to address these behavioral questions using cutting-edge molecular-genetic, genomic, proteomic, behavioral and microscopy tools to gain insights into complex behaviors.

项目概要/摘要 要了解心理健康和疾病，我们需要了解大脑的功能 基因、基因调控网络、神经元、电路结构和生理学。果蝇有 考虑到工具和技术的范围，它已成为解决这些问题的最强大的模型系统之一。 在所有这些层面上分析复杂行为的易处理性。该提案旨在了解 果蝇的生殖行为。果蝇如此强大的系统的一个原因是，性 指导生殖行为的特定主调控转录因子是已知的。这有 为识别和操纵这些神经元提供了强大的分子途径 行为。这些工具还可用于进行神经元特异性突变研究，以发现 指导行为的基因功能，利用了果蝇的最大优势之一 模型系统。此外，该系统提供了一个无与伦比的模型来检查性别特异性 这些神经元的发育以及它们如何被成人经历所改变。研究使用 果蝇模型继续揭示重要的生物学过程 人类健康和疾病，包括神经系统和行为的研究。该项工作将建设 我的实验室 15 年 NIGMS 资助的研究计划。我们将继续解决这些问题 使用尖端分子遗传学、基因组学、蛋白质组学、行为学和 显微镜工具可以深入了解复杂的行为。