Administrative Core (AC) Core A

行政核心 (AC) 核心 A

• 批准号: 10689303
• 负责人: CAROL A. BARNES
• 金额: $ 87.97万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689303
• 关键词: Advisory Committees; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Bioinformatics; Brain; Businesses; Cognitive; Cognitive aging; Collection; Communication; Communities; Complex; Conflict of Interest; Country; Data; Development; Effectiveness; Ensure; Epidemiology; Evaluation; Fostering; Funding; Goals; Grant; Health; Health Professional; Human Resources; Human Subject Research; Institution; Intellectual Property; Intervention; Lead; Leadership; Longevity; Longitudinal cohort; Measures; Monitor; Output; Performance; Personal Satisfaction; Process; Productivity; Reporting; Research; Research Personnel; Resource Sharing; Resources; Services; Travel; Universities; Update; algorithmic methodologies; analytical method; clinical research site; commercialization; design; experience; follow-up; healthspan; improved; industry partner; meetings; member; molecular marker; operation; outreach; prevent; recruit; success; tool

SUMMARY/ABSTRACT: Administrative Core A The Administrative Core (AC) will lead and coordinate operations of all Cores and Projects to assure success in achieving the strategic goals of the Precision Aging Network (PAN). PAN’s goals are to enable the development of individualized interventions to maintain health, well-being, and function to optimize cognitive healthspan and to prevent or reduce the burden of Alzheimer’s disease (AD) and AD-related dementias (ADRD). The AC will be led by Carol Barnes and Meredith Hay who have a combined several decades worth of administrative experience in directing large, complex projects. They will be assisted by the PAN Executive Committee and Steering Committee and advised by the External Advisory Committee in establishing priorities for center activities and resources, promoting optimal interactions, resolving potential conflicts of interest, reviewing and updating the research community, and implementing an ongoing evaluation plan with appropriate metrics and markers of productivity and impact. Key functions of the AC also include ensuring a robust data and biospecimen sharing plan, meeting coordination and follow-up, travel arrangements, financial allocations and reports, compliance with federal and institutional grants management and reporting requirements, collection, collation and confirmation of evaluation metrics. Overall progress will be assessed through the development of a multi-year Evaluation Plan with specific milestones to identify areas for improvement and initiate changes. The plan will be specifically designed to assess the (a) overall performance of PAN, including the effectiveness of the AC, and (b) productivity, effectiveness, utilization and opportunities of the Cores and Projects, and also (c) actively engage the external advisors in evaluation of the PAN leadership. Lastly, the AC will strengthen and expand robust, effective communication, dissemination and outreach activities by fostering mutually productive interactions among members of health professional, scientific and citizen communities. With input from the External Advisory Committee and NIA programmatic leadership, the Project Leads, co- Leads, Associate Investigators, and key personnel, the AC will ensure that PAN provides a broad-based data, biospecimen and resource sharing plan to facilitate the rapid and far-reaching use of the unique resources (biospecimens, raw and processed data, algorithms, and analytical methods) created by PAN. They will also expand interactions with the leadership and key personnel of other NIA-funded Alzheimer’s Disease Centers located at the four PAN clinical sites as well as across the country. Additionally, the AC will manage interactions with existing longitudinal cohorts designed to investigate aging, AD, and/or ADRD.

摘要/摘要：管理核心A 行政核心（AC）将领导和协调所有核心和项目的操作，以确保成功 实现精确老化网络（PAN）的战略目标。潘的目标是启用 开发个性化干预措施以维持健康，福祉和功能以优化认知 健康范围并预防或减少阿尔茨海默氏病（AD）和广告相关痴呆症的燃烧 （ADRD）。 AC将由卡罗尔·巴恩斯（Carol Barnes）和梅雷迪思·海伊（Meredith Hay）领导，他们的总价值数十年 指导大型复杂项目的行政经验。 PAN主管将协助他们 委员会和指导委员会，并由外部咨询委员会建议建立优先事项 用于中心活动和资源，促进最佳互动，解决潜在的利益冲突， 审查和更新研究社区，并与 适当的生产力和影响的指标和标记。 AC的关键功能还包括确保稳健的数据和生物测量共享计划，会议 协调和后续行动，旅行安排，财务分配和报告，遵守联邦和 机构赠款管理和报告要求，收集，协作和评估确认 指标。总体进步将通过制定多年评估计划来评估 具体的里程碑，以确定改进和启动变化的领域。该计划将是专门的 旨在评估PAN的（a）总体性能，包括AC的有效性，以及（b） 核心和项目的生产力，有效性，利用和机会，也（c）积极参与 泛领导评估的外部顾问。最后，AC将加强和扩大强大的强大， 通过促进相互生产的互动，有效的沟通，传播和推广活动 在卫生专业人员，科学和公民社区的成员中。 在外部咨询委员会和NIA计划领导的投入下，该项目领导，共同 领导者，副研究人员和关键人员，AC将确保PAN提供基于广泛的数据， 生物测量和资源共享计划，以促进独特资源的快速和深远使用 （Bispecimens，原始数据和处理的数据，算法和分析方法）由PAN创建。他们也会 扩大与其他NIA资助的阿尔茨海默氏病中心的领导和关键人员的互动 位于四个泛临床场地以及全国各地。此外，AC将管理 与旨在研究衰老，AD和/或ADRD的现有纵向同类队列的相互作用。