Postdoctoral Training, Neurobiology of Aging and Alzheimer's Disease

博士后培训，衰老和阿尔茨海默病的神经生物学

• 批准号: 10419557
• 负责人: CAROL A. BARNES
• 金额: $ 22.92万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10419557
• 关键词: Aging; Alzheimer' s Disease; Neurobiology; post-doctoral training

Project Summary/Abstract The postdoctoral training grant entitled “The Neurobiology of Aging and Alzheimer's Disease” is submitted through the University of Arizona on behalf of the Arizona Alzheimer's Consortium. The training faculty chosen from the Consortium consist of highly interactive investigators whose scientific interests include aging, Alzheimer's disease (AD) and AD-related dementias (ADRD) and spans fly, rodent, and nonhuman primate models of aging, as well as human studies in normative and pathological conditions of aging. Six institutions within the Consortium contribute Primary Mentors (Preceptors) and Affiliate Faculty to this Training Program, including: The University of Arizona, Arizona State University, Barrow Neurological Institute, Banner Sun Health Research Institute, The Translational Genomics Research Institute, and Banner Alzheimer's Institute. Faculty have complementary strengths in brain imaging, computer science, genomics, molecular biology, basic systems, behavioral and cognitive neuroscience, experimental therapeutics, computational and statistical analyses of complex datasets and clinical neuropathological approaches. The research is aimed at promoting the scientific understanding of the aging brain, early detection of AD and ADRD and developing effective treatment and prevention therapies. Fellows benefit from a 4 person Professional Development Committee (PDC) whose purpose is to provide guidance on the creation of a collaborative experimental training plan that fosters opportunities to work, learn and produce across institutions. The primary research Mentor, in whose laboratory the Fellow is based, is chosen from the Preceptor list, as is the secondary research Mentor, but they can be from any institution amongst the consortium. The secondary Mentor plays an active role in the research undertaken by the Fellow, which goes beyond making facilities available. A tertiary Mentor is selected on the basis of experimental or pedagogical expertise, and a fourth member of the PDC is chosen from amongst the 6-person leadership team to provide an additional level of oversight. Exposure to the unique Arizona tradition of cooperation and collaboration that knows no institutional boundaries has significantly enriched the skill sets and professional development of our Fellows during the training period. In addition to multi-laboratory research exposure, another unique programmatic aspect takes the form of three workshops per year, varying from 1-3 days, in which all Fellows participate. These include statewide events that Training Faculty attend (Annual Arizona Alzheimer's Consortium Retreat), or that faculty, graduate students and postdocs attend (Alzheimer's Consortium Annual Scientific Conference), as well as broader participation in national and international professional events (e.g., Society for Neuroscience meeting). Our goal to give the Fellow the freedom to draw broadly from facilities and expertise across the Consortium has exposed our Trainees to the power of collaborative, interdisciplinary interactions that can facilitate development of strong experimental designs to test important questions, providing the foundation for productive future work.

项目摘要/摘要 提交了题为“衰老和阿尔茨海默氏病的神经生物学”的博士后培训补助金 通过亚利桑那大学代表亚利桑那州阿尔茨海默氏症财团通过亚利桑那大学。选择的培训教师 从联盟中 阿尔茨海默氏病（AD）和与广告相关的痴呆症（ADRD）和跨度飞翔，啮齿动物和非人类隐私 衰老模型以及人类研究的正常和病理状况。六个机构 在财团内为这项培训计划的主要导师（主教）和会员教师 包括：亚利桑那大学，亚利桑那州立大学，巴罗神经学院，横幅太阳 卫生研究所，转化基因组学研究所和阿尔茨海默氏症研究所。 教师在大脑成像，计算机科学，基因组学，分子生物学，基本方面具有完成者的优势 系统，行为和认知神经科学，实验疗法，计算和统计 复杂数据集和临床神经病理学方法的分析。该研究旨在促进 对衰老大脑的科学理解，AD和ADRD的早期发现以及发展有效 治疗和预防疗法。研究员受益于4人专业发展委员会 （PDC）其目的是提供有关制定协作实验培训计划的指导 促进跨机构工作，学习和生产的机会。主要的研究导师，其中 实验室的研究员是从主教名单中选择的，二级研究导师也是如此，但他们是 可以来自财团中的任何机构。次级导师在 研究员进行的研究不仅仅是使设施可用。三级导师是 根据实验或教学专业知识选择，并选择PDC的第四个成员 从六人组成的领导团队中，可以提供额外的监督。暴露于独特 亚利桑那州的合作与合作传统，没有任何机构界限 在培训期间，我们的研究员的技能和专业发展丰富了。此外 多实验室研究暴露，另一个独特的程序化方面采用了三个研讨会的形式 每年从1-3天开始，所有研究员都参加。其中包括培训的全州活动 教师出勤（每年亚利桑那州阿尔茨海默氏症的财团务虚会） PostDocs出席（阿尔茨海默氏症联盟年度科学会议），并更广泛参与 国家和国际专业活动（例如神经科学会议）。我们的目标是给 研究员从联盟中广泛地从设施和专业知识中广泛汲取的自由已经暴露了我们的 学员掌握了协作，跨学科互动的力量，可以促进强大的发展 测试重要问题的实验设计，为未来的生产力提供了基础。