Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with a Substance Use Disorder

药物滥用障碍患者大脑连接性和光谱生物标志物的多参数 MRI 评估

基本信息

批准号：
10685347
负责人：
Brian Allen Taylor
金额：
$ 19.02万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10685347
关键词：
Amygdaloid structure Animals Anterior Attention Biological Markers Biology Board Certification Brain Brain region Centers for Disease Control and Prevention (U.S.)Cessation of life Clinical Cocaine use disorder Corpus striatum structure Coupling Cues Data Development Diagnosis Disease Drug usage Ethics Extinction Functional Magnetic Resonance Imaging Glutamates Goals Heroin Users Hippocampus Human Image Insula of Reil Intake Knowledge Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurable Measures Medical Mentors Methods Modality Modeling Nature Neurons Neurosciences Neurotransmitters Opioid Oxycodone Pathway interactions Patients Pharmaceutical Preparations Physics Physiological Physiology Prediction of Response to Therapy Prefrontal Cortex Reaction Time Relapse Reporting Research Research Personnel Rodent Self Administration Serotonin Agonists Services Societies Stimulus Substance Use Disorder Techniques Training Training Programs United States Work addiction attentional bias causal model cingulate cortex craving cue reactivity design drug craving gamma-Aminobutyric Acid imaging study indicated prevention mortality multimodality neural circuit neuroimaging neuromechanism neuronal circuitry opioid use opioid use disorder public health emergency relapse prediction research study response social substance use targeted treatment theories tool visual stimulus

项目摘要

Opioid use disorder (OUD) has been declared as a public health emergency in the United States. Data from the Centers for Disease Control and Prevention indicate a fivefold increase in the number of deaths due to opioids from 1999 to 2016. Neuroimaging is a powerful tool in understanding the neurocircuitry and physiology of OUD in order to target treatments for patients suffering from this disorder. This K23 application presents a training program for a board-certified clinical medical physicist, who specializes in magnetic resonance imaging (MRI), in order to receive training in the neuroscience of substance use disorders and to become an independent investigator. The goals set in this application will build on the candidate’s imaging physics background by (1) developing a foundational knowledge of brain function and neurocircuitry in substance use disorders in order to design, optimize, and interpret advanced neuroimaging techniques for addiction research; (2) acquiring training in professional development to become an independent investigator, mentor and educator; and (3) receiving additional training in the responsible and ethical conduct of scientific research. The overall training program will involve a research study focused on (1) brain effective connectivity (i.e., directional connectivity) of neural circuits in OUD, and (2) magnetic resonance spectroscopic quantification of neurotransmitters related to these circuits. In this proposed work, we will employ fMRI-based dynamic causal modeling of effective connectivity with guided expertise from mentors in order to identify neurocircuits underlying drug craving and attentional bias to dug cues. In addition, we will use MR spectroscopy to investigate the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate in OUD and their relation to drug craving and attentional bias, and to explore the association of these neurotransmitters with brain effective connectivity.

阿片类药物使用障碍 (OUD) 已被宣布为美国的突发公共卫生事件数据来自。疾病控制和预防中心表示，由于新冠肺炎导致的死亡人数增加了五倍 1999 年至 2016 年阿片类药物。神经影像学是了解神经回路和生理学的强大工具 OUD 的目的是针对患有这种疾病的患者进行治疗。此 K23 应用程序提供了一种方法。针对专门从事磁共振成像的委员会认证临床医学物理学家的培训计划（MRI），以便接受物质使用障碍神经科学方面的培训并成为一名本申请中设定的目标将建立在候选人的成像物理学基础上。 (1) 发展物质使用中大脑功能和神经回路的基础知识疾病，以便设计、优化和解释用于成瘾研究的先进神经影像技术； (2) 接受专业发展培训，成为独立调查员、导师和教育工作者；(3) 接受负责任和道德的科学研究行为的额外培训。总体培训计划将涉及一项研究，重点关注 (1) 大脑有效连接（即定向 OUD 中神经回路的连接性），以及（2）磁共振波谱定量在这项拟议的工作中，我们将采用基于功能磁共振成像的动态因果关系。利用导师的指导专业知识对有效连接进行建模，以识别神经回路此外，我们将使用 MR 光谱来挖掘潜在的药物渴望和注意力偏差。研究 OUD 中的神经递质 γ-氨基丁酸 (GABA) 和谷氨酸及其关系药物渴望和注意力偏差，并探索这些神经递质与大脑的关联有效的连接。