Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with Opioid Use Disorder

阿片类药物使用障碍患者大脑连接性和光谱生物标志物的多参数 MRI 评估

• 批准号: 9975514
• 负责人: Brian Allen Taylor
• 金额: $ 19.19万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9975514
• 关键词: Alcohol or Other Drugs use; Amygdaloid structure; Animals; Anterior; Attention; Biological Markers; Biology; Brain; Brain region; Centers for Disease Control and Prevention (U.S.); Cessation of life; Clinical; Corpus striatum structure; Coupling; Cues; Data; Development; Diagnosis; Disease; Drug usage; Ethics; Extinction (Psychology); Foundations; Functional Magnetic Resonance Imaging; Glutamates; Goals; Heroin Users; Hippocampus (Brain); Human; Image; Insula of Reil; Intake; Knowledge; Lead; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurable; Measures; Medical; Mentors; Methods; Modeling; Nature; Neurons; Neurosciences; Neurotransmitters; Opioid; Oxycodone; Pathway interactions; Patients; Pharmaceutical Preparations; Physics; Physiological; Physiology; Prediction of Response to Therapy; Prefrontal Cortex; Reaction Time; Relapse; Reporting; Research; Research Personnel; Rodent; Self Administration; Serotonin Agonists; Services; Societies; Stimulus; Substance Use Disorder; Techniques; Training; Training Programs; United States; Work; addiction; attentional bias; base; causal model; cingulate cortex; cocaine use; craving; cue reactivity; design; drug craving; gamma-Aminobutyric Acid; imaging modality; imaging study; indicated prevention; mortality; multimodality; neural circuit; neuroimaging; neuromechanism; neuronal circuitry; opioid use; opioid use disorder; public health emergency; relapse prediction; research study; response; social; targeted treatment; tool; visual stimulus

Opioid use disorder (OUD) has been declared as a public health emergency in the United States. Data from the Centers for Disease Control and Prevention indicate a fivefold increase in the number of deaths due to opioids from 1999 to 2016. Neuroimaging is a powerful tool in understanding the neurocircuitry and physiology of OUD in order to target treatments for patients suffering from this disorder. This K23 application presents a training program for a board-certified clinical medical physicist, who specializes in magnetic resonance imaging (MRI), in order to receive training in the neuroscience of substance use disorders and to become an independent investigator. The goals set in this application will build on the candidate’s imaging physics background by (1) developing a foundational knowledge of brain function and neurocircuitry in substance use disorders in order to design, optimize, and interpret advanced neuroimaging techniques for addiction research; (2) acquiring training in professional development to become an independent investigator, mentor and educator; and (3) receiving additional training in the responsible and ethical conduct of scientific research. The overall training program will involve a research study focused on (1) brain effective connectivity (i.e., directional connectivity) of neural circuits in OUD, and (2) magnetic resonance spectroscopic quantification of neurotransmitters related to these circuits. In this proposed work, we will employ fMRI-based dynamic causal modeling of effective connectivity with guided expertise from mentors in order to identify neurocircuits underlying drug craving and attentional bias to dug cues. In addition, we will use MR spectroscopy to investigate the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate in OUD and their relation to drug craving and attentional bias, and to explore the association of these neurotransmitters with brain effective connectivity.

在美国，阿片类药物使用障碍（OUD）已被宣布为公共卫生紧急情况。 疾病控制和预防中心表明，由于 从1999年到2016年的阿片类药物。神经影像学是理解神经记录和生理学的强大工具 OUD的目的是针对此疾病的专门治疗。 专门从事磁共振成像的董事会认证的临床医学物理学家的培训计划 （MRI），为了接受有关药物使用障碍神经科学的培训，并成为一种 独立研究者。 背景通过（1）在物质使用中发展脑功能和神经通路的基础知识 疾病以设计，优化和国际技术技术来进行添加研究； （2）获得专业发展的培训，成为独立研究者，导师和 教育者和（3）接受对科学研究的反应和道德行为的额外培训 总体培训计划涉及一项研究研究，重点是（1）大脑有效连接（即定向 OUD神经回路的连通性）和（2）磁共振光谱定量 与这些电路有关的神经递质。 与导师的指导专业知识一起建模有效的结缔组织，以识别神经科目 渴望和dug dug提示的基本药物偏见。 研究神经递质γ-氨基丁酸（GABA）和谷氨酸及其关系 渴望药物和同性恋偏见，并探索See神经递质与脑部的关联 有效的连接。