Multi-parametric MRI Assessment of Brain Connectivity and Spectroscopic Biomarkers in Patients with a Substance Use Disorder

药物滥用障碍患者大脑连接性和光谱生物标志物的多参数 MRI 评估

基本信息

批准号：
10229537
负责人：
Brian Allen Taylor
金额：
$ 19.17万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10229537
关键词：
Amygdaloid structure Animals Anterior Attention Biological Markers Biology Brain Brain region Centers for Disease Control and Prevention (U.S.)Cessation of life Clinical Corpus striatum structure Coupling Cues Data Development Diagnosis Disease Drug usage Ethics Extinction (Psychology)Foundations Functional Magnetic Resonance Imaging Glutamates Goals Heroin Users Hippocampus (Brain)Human Image Insula of Reil Intake Knowledge Lead Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurable Measures Medical Mentors Methods Modeling Nature Neurons Neurosciences Neurotransmitters Opioid Oxycodone Pathway interactions Patients Pharmaceutical Preparations Physics Physiological Physiology Prediction of Response to Therapy Prefrontal Cortex Reaction Time Relapse Reporting Research Research Personnel Rodent Self Administration Serotonin Agonists Services Societies Stimulus Substance Use Disorder Techniques Training Training Programs United States Work addiction attentional bias base causal model cingulate cortex cocaine use craving cue reactivity design drug craving gamma-Aminobutyric Acid imaging modality imaging study indicated prevention mortality multimodality neural circuit neuroimaging neuromechanism neuronal circuitry opioid use opioid use disorder public health emergency relapse prediction research study response social substance use targeted treatment tool visual stimulus

项目摘要

Opioid use disorder (OUD) has been declared as a public health emergency in the United States. Data from the Centers for Disease Control and Prevention indicate a fivefold increase in the number of deaths due to opioids from 1999 to 2016. Neuroimaging is a powerful tool in understanding the neurocircuitry and physiology of OUD in order to target treatments for patients suffering from this disorder. This K23 application presents a training program for a board-certified clinical medical physicist, who specializes in magnetic resonance imaging (MRI), in order to receive training in the neuroscience of substance use disorders and to become an independent investigator. The goals set in this application will build on the candidate’s imaging physics background by (1) developing a foundational knowledge of brain function and neurocircuitry in substance use disorders in order to design, optimize, and interpret advanced neuroimaging techniques for addiction research; (2) acquiring training in professional development to become an independent investigator, mentor and educator; and (3) receiving additional training in the responsible and ethical conduct of scientific research. The overall training program will involve a research study focused on (1) brain effective connectivity (i.e., directional connectivity) of neural circuits in OUD, and (2) magnetic resonance spectroscopic quantification of neurotransmitters related to these circuits. In this proposed work, we will employ fMRI-based dynamic causal modeling of effective connectivity with guided expertise from mentors in order to identify neurocircuits underlying drug craving and attentional bias to dug cues. In addition, we will use MR spectroscopy to investigate the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate in OUD and their relation to drug craving and attentional bias, and to explore the association of these neurotransmitters with brain effective connectivity.

在美国，阿片类药物使用障碍（OUD）已被宣布为公共卫生紧急情况。来自疾病控制和预防中心表明，由于从1999年到2016年的阿片类药物。神经影像学是理解神经记录和生理学的强大工具 OUD的目的是针对患有这种疾病的患者的治疗。此K23应用程序呈现专门从事磁共振成像的董事会认证的临床医学物理学家的培训计划（MRI），为了接受有关药物使用障碍神经科学的培训，并成为一种独立研究者。该应用程序中设定的目标将基于候选人的成像物理背景通过（1）在物质使用中发展脑功能和神经通路的基础知识为了设计，优化和解释成瘾研究的高级神经影像学技术的疾病；（2）获得专业发展的培训，成为独立研究者，导师和教育家（3）接受有关科学研究的负责任和道德行为的额外培训。整体培训计划将涉及一项研究的研究，重点是（1）大脑有效连通性（即定向 OUD神经回路的连通性）和（2）磁共振光谱定量神经递质与这些电路有关。在这项拟议的工作中，我们将采用基于fMRI的动态催化与导师的指导专业知识的有效连通性建模，以识别神经环节潜在的渴望药物和注意力提示的注意力偏见。此外，我们将使用MR光谱法在OUD中研究神经递质γ-氨基丁酸（GABA）和谷氨酸及其关系渴望药物和注意力偏见，并探索这些神经递质与脑的关联有效的连通性。