From First Breath: Lung Development, Infection, Repair and Aging

从第一次呼吸开始：肺部发育、感染、修复和衰老

基本信息

批准号：
10678811
负责人：
TERRY L. SHEPPARD
金额：
$ 1.65万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10678811
关键词：
Acceleration Address Age Aging Air Pollution Antiviral Response Area Articulation Asthma Biology Cell Communication Cells Cellular biology Chronic Obstructive Pulmonary Disease Collaborations Data Development Disease Disease susceptibility Educational workshop Emerging Technologies Epigenetic Process Epithelium Fostering Friends Geographic Locations Goals Health Immune Immune response Individual Infection Inflammation Joints Knowledge Learning Life Life Cycle Stages Lung Lung diseases Malignant neoplasm of lung Metabolism Methodology Modeling Morbidity - disease rate Natural regeneration Oral Outcome Participant Persons Pneumonia Population Predisposition Process Publications Pulmonary Fibrosis Pulmonary Hypertension Research Research Personnel Risk Factors Scientist Speed Stimulus Time Tobacco smoking behavior Utah Virus Diseases Work antenatal biological adaptation to stress career cell stroma clinical practice design ethnic diversity field study forging gender diversity improved insight lung development lung health meetings mortality novel posters programs regenerative repaired response social symposium synergism

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled From First Breath: Lung Development, Infection, Repair and Aging, organized by Drs. Carla Kim, Benjamin Singer and Nan Tang. The conference will be held in Snowbird, Utah from April 23 - 26, 2023. Lung diseases represent leading causes of morbidity and mortality worldwide. Beginning with antenatal development, the lung undergoes changes throughout the life course because of aging, as well as in response to infection and other injurious stimuli. There exist knowledge gaps in how individual cell populations coordinate and respond to these changes in states of health and disease over time. Therefore, this conference was designed to address how specific cell populations contribute to the formation and regeneration of the lung over the life course, as well as to examine metabolism, epigenetics, stress responses, and cell-cell interactions as features that control lung biology and how control mechanisms change over stages of life. This program will also aim to understand how emerging technologies and models will elucidate fundamental mechanisms of lung health and disease, and finally, how to articulate how the host immune response to infection determines reparative and regenerative processes. As a result of this meeting, attendees will have a more comprehensive view of dynamic mechanisms that drive pulmonary biology as it relates to health and disease as well as the newest approaches with which to understand these concepts. Finally, this conference will be held with another Keystone Symposia Conference, “Inflammation in the Lung: Friend or Foe in Viral Infections?” This pairing will allow participants to bridge the gap between classical antiviral responses carried out by innate and adaptive immune cells, and the involvement of other lung cells such as epithelia and stroma cells, and to deepen the understanding on how these cells interact. Ultimately, this Symposium will impact the field of lung biology by bringing together interdisciplinary groups of scientists that will synergize to propel discovery of mechanisms underlying lung health and disease.

抽象的请求支持题为“从第一次呼吸开始：肺发育”的 Keystone 研讨会，感染、修复和衰老，由 Carla Kim 博士、Benjamin Singer 和 Nan Tang 组织。将于 2023 年 4 月 23 日至 26 日在犹他州斯诺伯德举行。从产前开始，肺部疾病就是全球发病和死亡的主要原因。在发育过程中，肺部在整个生命过程中会因衰老以及反应而发生变化对于感染和其他有害刺激的影响，在个体细胞群如何受到影响方面存在知识差距。因此，本次会议旨在协调和应对健康和疾病状况的这些变化。旨在解决特定细胞群如何促进肺的形成和再生整个生命过程，以及检查新陈代谢、表观遗传学、应激反应和细胞间相互作用作为控制肺部生物学的特征以及控制机制如何在生命阶段变化。还旨在了解新兴技术和模型将如何阐明肺的基本机制健康和疾病，最后，如何阐明宿主免疫反应如何确定感染此次会议的结果是，与会者将获得更全面的修复和再生过程。驱动肺部生物学的动态机制的观点，因为它与健康和疾病以及最后，本次会议将与另一场会议一起举行。 Keystone 研讨会，“肺部炎症：病毒感染中的朋友还是敌人？” 允许参与者弥合先天性和适应性的经典抗病毒反应之间的差距免疫细胞，以及其他肺细胞（例如上皮细胞和基质细胞）的参与，并加深最终，本次研讨会将通过了解这些细胞如何相互作用来影响肺生物学领域。将跨学科的科学家小组聚集在一起，共同推动机制的发现潜在的肺部健康和疾病。