P30 Center Core Grant for Vision Research

P30 中心视觉研究核心资助

• 批准号: 10696213
• 负责人: Raju VS Rajala
• 金额: $ 29.49万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696213
• 关键词: Animal Experimentation; Animal Model; Animals; Area; Breeding; Center Core Grants; Collaborations; Core Grant; Data; Data Analyses; Data Collection; Dedications; Disease model; Electrophysiology (science); Electroretinography; Environment; Equipment; Eye diseases; Faculty; Fostering; Funding; Genotype; Glaucoma; Grant; Guidelines; Health Sciences; Housing; Human Resources; Humidity; Hyperoxia; Hypoxia; Image; Infection; Inflammation; Laboratories; Light; Location; Microscopy; Modeling; Mus; Oklahoma; Ophthalmoscopy; Optical Coherence Tomography; Pathogenesis; Physiology; Postdoctoral Fellow; Reproducibility; Research; Research Personnel; Scientist; System; Therapeutic; Training; Training and Education; Transgenic Animals; Universities; Vision; Vision research; animal imaging; animal model development; dark rearing; experimental analysis; experimental study; graduate student; in vivo; instrument; instrumentation; laser photocoagulation; recruit; skills; tonometry; user-friendly; vision development

ABSTRACT Animal Analysis Core Vision research requires the use of various animal models to investigate the mechanisms of visual development and degeneration, the pathogenesis of blinding infection and inflammation, and the efficacy of vision-saving therapeutics. The Live Animal Imaging and Functional Analysis Core at the University of Oklahoma Health Sciences Center is responsible for providing vision researchers with state-of-the-art instrumentation in the physiology and function of vision in small animal models of development, degeneration, infection, and inflammation. These Cores support vision research on 16 NEI-funded R01 grants and other vision-related projects at OUHSC in two different locations within vivaria, which allows in/out privileges. More than 40 ocular disease models and more than 70 genetically altered mouse lines are currently being analyzed with electrophysiological, genotyping, functional analysis, microscopy, and other support equipment in expanded research areas renovated specifically for this use. The instrumentation provided by this Core includes electroretinography (in vivo and ex vivo), optical coherence tomography, fundoscopy, optokinetics, laser photocoagulation, tonometry, indirect ophthalmoscopy, and slit lamp and biomicroscopic imaging. Environmental housing also includes equipment for light damage, dark rearing, hypoxia/hyperoxia, controlled humidity, and glaucoma models. Genotyping provides accurate data for breeding transgenic animals for vision research. Our Systems Managers are highly skilled in training personnel, assisting with experiments and data analysis, and maintaining core equipment to a quality standard. As such, this Core consolidates and provides instrumentation and expertise which would otherwise be too expensive or logistically difficult for vision researchers across campus to easily access. As in the previous funding period, this Core is motivated and committed to providing an effective, efficient, user-friendly, and high-quality research environment for all vision researchers at OUHSC.

抽象的 动物分析核心 视力研究需要使用各种动物模型来研究视觉的机制 发育和变性，盲感染和炎症的发病机理以及 避免视觉治疗。现场动物成像和功能分析核心的核心 俄克拉荷马州健康科学中心负责为视觉研究人员提供最先进的 在小型动物的发展模型，变性的小动物模型中，仪器在视觉和功能中 感染和炎症。这些核心支持对16个NEI资助的R01赠款和其他的视觉研究 Vivaria内两个不同位置的OUHSC的与视觉相关的项目，该项目允许受到/消除特权。更多的 目前正在分析40个眼科疾病模型和70多个遗传变化的小鼠线 具有电生理，基因分型，功能分析，显微镜和其他支持设备 针对此用途进行了专门翻新的扩展研究领域。该核心提供的仪器 包括电视图（体内和Ex Vivo），光学相干断层扫描，基础镜，光动力学， 激光光凝，传动力计，间接眼镜检查和缝隙灯和生物显微镜成像。 环境外壳还包括用于轻损伤，深度饲养，缺氧/高氧的设备 湿度和青光眼模型。基因分型为视觉繁殖的转基因动物提供了准确的数据 研究。我们的系统经理在培训人员方面非常熟练，协助实验和数据 分析，并将核心设备保持在质量标准中。因此，此核心合并并提供 仪器和专业知识，否则对于视力而言太昂贵或在逻辑上很难 校园各地的研究人员可以轻松进入。与上一个资金期一样，此核心是有动力的，并且 致力于为所有愿景提供有效，高效，用户友好和高质量的研究环境 OUHSC的研究人员。