P30 Center Core Grant for Vision Research

P30 中心视觉研究核心资助

基本信息

批准号：
10477417
负责人：
Raju VS Rajala
金额：
$ 29.49万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10477417
关键词：
Animal Experimentation Animal Model Animals Area Breeding Center Core Grants Collaborations Core Grant Data Data Analyses Data Collection Disease model Electrophysiology (science)Electroretinography Environment Equipment Faculty Fostering Funding Genotype Glaucoma Grant Guidelines Health Sciences Housing Human Resources Humidity Hyperoxia Hypoxia Image Infection Inflammation Laboratories Light Location Logistics Microscopy Modeling Mus Oklahoma Ophthalmoscopy Optical Coherence Tomography Pathogenesis Physiology Postdoctoral Fellow Reproducibility Research Research Personnel Savings Scientist System Therapeutic Training Training and Education Transgenic Animals Universities Vision Vision research animal imaging animal model development dark rearing experimental study graduate student in vivo instrument instrumentation laser photocoagulation ranpirnase recruit tonometry user-friendly vision development

项目摘要

ABSTRACT Animal Analysis Core Vision research requires the use of various animal models to investigate the mechanisms of visual development and degeneration, the pathogenesis of blinding infection and inflammation, and the efficacy of vision-saving therapeutics. The Live Animal Imaging and Functional Analysis Core at the University of Oklahoma Health Sciences Center is responsible for providing vision researchers with state-of-the-art instrumentation in the physiology and function of vision in small animal models of development, degeneration, infection, and inflammation. These Cores support vision research on 16 NEI-funded R01 grants and other vision-related projects at OUHSC in two different locations within vivaria, which allows in/out privileges. More than 40 ocular disease models and more than 70 genetically altered mouse lines are currently being analyzed with electrophysiological, genotyping, functional analysis, microscopy, and other support equipment in expanded research areas renovated specifically for this use. The instrumentation provided by this Core includes electroretinography (in vivo and ex vivo), optical coherence tomography, fundoscopy, optokinetics, laser photocoagulation, tonometry, indirect ophthalmoscopy, and slit lamp and biomicroscopic imaging. Environmental housing also includes equipment for light damage, dark rearing, hypoxia/hyperoxia, controlled humidity, and glaucoma models. Genotyping provides accurate data for breeding transgenic animals for vision research. Our Systems Managers are highly skilled in training personnel, assisting with experiments and data analysis, and maintaining core equipment to a quality standard. As such, this Core consolidates and provides instrumentation and expertise which would otherwise be too expensive or logistically difficult for vision researchers across campus to easily access. As in the previous funding period, this Core is motivated and committed to providing an effective, efficient, user-friendly, and high-quality research environment for all vision researchers at OUHSC.