Core B: Biostatistics and Computational Biology

核心 B：生物统计学和计算生物学

• 批准号: 10668337
• 负责人: MEREDITH M REGAN
• 金额: $ 18.59万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-17 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668337
• 关键词: Animals; Area; Biometry; Cancer Center; Clinical; Clinical Research; Collaborations; Computational Biology; Computer software; Consultations; Correlative Study; Data; Data Analyses; Data Collection; Data Storage and Retrieval; Databases; Development; Ensure; Genomics; Goals; Laboratories; Libraries; Outcome; Reporting; Reproduction spores; Research; Research Activity; Research Design; Research Personnel; Resource Sharing; Resources; Software Design; Systems Integration; Translational Research; Writing; career; computing resources; cost effective; data exchange; data integrity; data management; data quality; design; epidemiology study; experience; high standard; malignant breast neoplasm; pre-clinical; programs; quality assurance

PROJECT SUMMARY The Dana-Farber/Harvard Cancer Center (DF/HCC) SPORE in Breast Cancer Biostatistics and Computational Biology Core (Core B) collaborates and provides consultation on all research activities within the SPORE, including SPORE Projects, Developmental Research Program and Career Enhancement Program projects to ensure the highest standards of scientific rigor in areas of study design, data management and integrity, and data analysis and interpretation. The overarching goal is to promote translational research derived from fundamental discoveries in the laboratory that can lead to tangible clinical benefit. The specific aims of Core B are to: (1) provide biostatistical and computational biology expertise for the planning and design, conduct, analysis, and reporting of laboratory, genomic, animal, translational, clinical (including associated correlative studies), and epidemiological studies for SPORE Projects, Developmental Research and Career Enhancement projects, and other SPORE Cores; (2) provide consultation on all issues of data management and integrity, including: a) data collection and storage, b) data transfer and quality assurance, c) statistical and computational biology software and programs, and d) integration of preclinical data and correlative findings with parameters and outcomes from clinical studies databases; and (3) provide short-term biostatistics and computational biology consulting to the entire group of SPORE researchers. Organizing biostatistical and computational biology expertise as a shared resource core is a cost-effective approach to ensure that collaboration is readily available to SPORE investigators and is an effective strategy to guarantee a high degree of integration among projects, which have interrelated analytic goals and needs. Core B has a wealth of experienced biostatisticians and computational biologists equipped with excellent computational support, including major commercial and public-use statistical software, and a large library of locally written software for design and analysis.

项目摘要 乳腺癌生物统计学和计算 生物学核心（核心B）合作并就孢子中的所有研究活动进行咨询， 包括孢子项目，发展研究计划和职业增强计划项目 确保在研究设计，数据管理和完整性领域的科学严谨性最高标准以及 数据分析和解释。总体目标是促进从 实验室中的基本发现可能会导致切实的临床益处。 核心B的具体目的是：（1）为计划提供生物统计学和计算生物学专业知识 以及实验室，基因组，动物，翻译，临床的设计，进行，分析和报告（包括 相关的相关研究）以及用于孢子项目，发展研究和的流行病学研究 职业增强项目和其他孢子核心； （2）就所有数据问题提供咨询 管理和完整性，包括：a）数据收集和存储，b）数据传输和质量保证，c） 统计和计算生物学软件和程序，d）临床前数据和相关性的集成 来自临床研究数据库的参数和结果的发现； （3）提供短期生物统计学 以及向整个孢子研究人员组的计算生物学咨询。 组织生物统计学和计算生物学专业知识作为共享资源核心是一种成本效益 确保协作可以随时可用于孢子调查人员的方法，并且是一种有效的策略 确保项目之间的高度整合，这些项目与分析目标和需求相关。核 B拥有丰富的经验丰富的生物统计学家和配备出色的计算生物学家 计算支持，包括主要的商业和公共用途统计软件，以及大型库 用于设计和分析的本地编写软件。