Biostatistics/Computational Core

生物统计学/计算核心

• 批准号: 10628275
• 负责人: Svitlana Tyekucheva
• 金额: $ 16.55万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628275
• 关键词: Animals; Area; Award; Biometry; Cancer Center; Clinical; Clinical Research; Collaborations; Computational Biology; Computer software; Consultations; Correlative Study; Data Analyses; Data Collection; Databases; Development; Ensure; Genomics; Goals; Laboratories; Libraries; Outcome; Prostate; Reporting; Research; Research Activity; Research Design; Research Personnel; Resource Sharing; Software Design; Translational Research; Writing; career; computing resources; cost effective; data integrity; data management; design; epidemiology study; experience; high standard; programs; quality assurance

PROJECT SUMMARY – BIOSTATISTICS AND COMPUTATIONAL CORE (CORE B) The Biostatistics and Computational Core (Core B) of the Dana-Farber/Harvard Cancer Center (DF/HCC) Prostate SPORE interacts with all research activities within the SPORE, including the SPORE Projects, Developmental Research Program, and Career Enhancement Program to ensure the highest standards of scientific rigor in areas of study design, data management and integrity, and data analysis and interpretation. The overarching goal is to promote translational research derived from fundamental discoveries in the laboratory that can lead to tangible clinical benefit. The specific aims of Core B are to: (1) provide biostatistical and computational biology expertise for the planning and design, conduct, analysis, and reporting of laboratory, genomic, animal, translational, clinical (including associated correlative studies), and epidemiological studies for SPORE Projects, Developmental Research, and Career Enhancement Award projects, and other SPORE Cores; (2) provide consultation on all issues of data management, integrity and integration, including data collection, storage, transfer, sharing and quality assurance, on statistical and computational software and programs, and on coordination of laboratory results with parameters and outcomes from clinical studies or clinical/translational research databases; and (3) provide short-term biostatistics and computational biology consulting to the entire group of SPORE researchers. Organizing biostatistical and computational biology expertise as a shared resource core is a cost-effective approach to ensure that collaboration is readily available to SPORE investigators and is an effective strategy to guarantee a high degree of integration among projects, which have interrelated analytic goals and needs. Core B has a wealth of experienced biostatisticians and computational biologists equipped with excellent computational resources, including major commercial and public-use statistical software and a large library of locally written software for design and analysis.

项目摘要 – 生物统计学和计算核心（核心 B） 达纳法伯/哈佛大学癌症中心 (DF/HCC) 的生物统计学和计算核心（核心 B） 前列腺 SPORE 与 SPORE 内的所有研究活动相互作用，包括 SPORE 项目、 发展研究计划和职业提升计划，以确保最高标准 研究设计、数据管理和完整性以及数据分析和解释领域的科学研究。 总体目标是促进基于基础发现的转化研究 能够带来切实临床效益的实验室 核心 B 的具体目标是： (1) 提供 生物统计和计算生物学专业知识，用于规划和设计、实施、分析和 实验室、基因组、动物、转化、临床（包括相关的相关研究）的报告，以及 SPORE 项目的流行病学研究、发展研究和职业提升奖 (2) 就数据管理、完整性和所有问题提供咨询 整合，包括统计和数据收集、存储、传输、共享和质量保证 计算软件和程序，以及实验室结果与参数的协调 临床研究或临床/转化研究数据库的结果；(3) 提供短期结果； 为整个 SPORE 研究人员提供生物统计学和计算生物学咨询。 生物统计和计算生物学专业知识作为共享资源核心是一种具有成本效益的方法 确保 SPORE 调查人员可以随时进行协作，并且这是一种有效的策略 保证具有相互关联的分析目标和需求的项目之间的高度集成。 Core B拥有丰富的经验丰富的生物统计学家和计算生物学家，配备了优秀的 计算资源，包括主要商业和公共使用统计软件以及大型图书馆 用于设计和分析的本地编写的软件。