Voice Source and Airway Interation in Normal and Hyperfunctional Speech

正常和功能亢进言语中的声源和气道相互作用

基本信息

批准号：
10668495
负责人：
INGO R TITZE
金额：
$ 52.7万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10668495
关键词：
3-Dimensional Acoustics Address Adopted Adult Air Movements Area Articulation Biology Chronic Laryngitis Clinical Compensation Computer-Aided Design Coping Skills Coupled Data Disease Dysphonia Epiglottis structure Equation Etiology Feedback Female Fiber Frequencies Gel Gestures Image Impairment Label Laryngeal muscle structure Larynx Left Liquid substance Loudness Measures Mechanics Medial Methodology Modeling Motion Movement Muscle Muscle Tension Myocardium Operative Surgical Procedures Outcome Output Paralysed Paresis Patients Pattern Periodicity Pharyngeal structure Phase Physics Physiological Posture Process Production Reporting Research Science Severities Shapes Source Speech Speed Structure Surface System Time Tissues Training Validation Ventricular Visual Visualization Voice Voice Disorders Voice Quality constriction density design fluid flow glottis human subject improved insight lung pressure male neural physical model physiologic model pressure programs self organization simulation sound vibration vocal cord vocalization voice therapy

项目摘要

PROJECT SUMMARY/ABSTRACT The severity of voice disorders is often described in terms of roughness in the laryngeal sound source. Much research has been undertaken to describe and quantify this roughness with perceptual, acoustic, and visual imaging methodologies. While these approaches provide a useful description of the final outcome of a disordered system, they say little about the internal system interactions that lead to this outcome. Self- sustained vocal fold vibration in an airway is an example of a highly interactive (nonlinear) process that has the ability to self-organize. If interaction is strong enough, with energy flowing bi-directionally between components, a structurally disorganized system can become functionally organized. Two asymmetric vocal folds with independent and unrelated natural vibration patterns can synchronize their combined motions as long as energy is allowed to flow between them. Thus, synchronization in coupled oscillators has become an important part of the physics and biology of self-organization. New opportunities will open up for clinicians who re-structure or re-program an impaired vocal system. The first aim is designed to improve the computational fluid dynamics of the voice simulator VoxInSilico. Critical shapes of an asymmetrical 3D glottis (airspace between the vocal folds) will be examined that include a variety of contact patterns on the medial surfaces of the vocal folds. The critical shapes will then define the airflow channels, for which isobar contour lines will be derived. To maintain both speed and fidelity of computation, analytical approximations will be developed for the isobars so that interpolations can be made between time steps in a glottal cycle during later time-dependent simulations. Further validation of the isobar contours will be obtained with three-dimensional computer assisted design (CAD) of physical models of the glottal shapes. Pressure taps will be placed so that gradients of pressure can be determined in coronal and horizontal planes. The second aim is to explore synchronization for asymmetric vocal folds with modified airway structures above the vocal folds. The clinical condition known as hyper-function will be addressed. The laryngeal and pharyngeal regions of the vocal tract will be systematically widened and narrowed for decreased and increased source-filter interaction. Vocal efficiency and periodicity measures will be compared to non-interactive baseline cases. The remaining two aims address source-filter interaction in connected speech, where both prosodics and articulation vary continuously. Contours for sound pressure level and fundamental frequency (SPL- fo), as well as contours in vowel space (F1 - F2), will be obtained from adult speakers using limited, normal, and heightened speech gestures. Synchronization between harmonics nfo and formants F1 and F2 will be determined. Vocal efficiency and periodicity will be compared.

项目摘要/摘要语音障碍的严重程度通常用喉声源中的粗糙度来描述。已经进行了许多研究，以描述和用知觉，声学和视觉成像方法。尽管这些方法为最终结果提供了有用的描述无序系统，他们对导致这种结果的内部系统相互作用几乎没有说。自己- 气道中的持续声折振动是具有高度互动（非线性）过程的示例自我组织的能力。如果相互作用足够强，则能量在两方向上流动组件，结构杂乱无章的系统可以在功能上组织起来。两个不对称的人声具有独立和无关的自然振动模式的折叠可以使其组合运动同步为只要允许能量在它们之间流动。因此，耦合振荡器中的同步已成为自组织的物理学和生物学的重要组成部分。新机会将为临床医生开放重新结构或重新编程的人声系统。第一个目的旨在改善语音模拟器素的计算流体动力学。将检查不对称3D气孔的临界形状（声音之间的空域）将检查包括一个声带内侧表面上的各种接触模式。然后，关键形状将定义气流通道将导出等尺度轮廓线。保持速度和保真度计算，分析近似将针对等速器开发，以便可以进行插值在以后的时间依赖性模拟期间，时间步长之间的时间步长。进一步验证isobar 轮廓将通过三维计算机辅助设计（CAD）获得发光的形状。将放置压力水龙头，以便可以在冠状和水平飞机。第二个目的是探索与经过修改的气道结构的不对称声折的同步在声带上方。将解决称为超功能的临床状况。喉和声带的咽区将系统地扩大和缩小，以减少和增加源滤波器相互作用。人声效率和周期性度量将与非交互性基线进行比较案例。其余两个目的解决了互联语音中的源滤波器互动，这两个韵律都在其中和发音不断变化。音压水平和基本频率（SPL-FO）的轮廓，AS 以及使用有限，正常和言语手势提高。谐波NFO和架动剂F1和F2之间的同步将是决定。将比较声音效率和周期性。