RR&D Research Career Scientist Award Application

基本信息

批准号：
10533303
负责人：
Robert L Mauck
金额：
--
依托单位：
PHILADELPHIA VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10533303
关键词：
Academy Acceleration Address American Anatomy Animal Model Area Award Biocompatible Materials Biological Biomechanics Biomedical Engineering Biomimetics Biophysics Black race Book Chapters Cartilage Cell Nucleus Cell Therapy Cells Cellular Infiltration Chondrogenesis Coculture Techniques Communication Custom Degenerative polyarthritis Dense Connective Tissue Development Doctor of Philosophy Drug Delivery Systems Education Elements Engineering Environment Epitopes Extracellular Matrix Foundations Gait General Population Goals Goat Growth Health Human Hydrogels In Vitro Incidence International Intervertebral disc structure Joints Journals K-Series Research Career Programs Knee Laboratory Research Length Manuscripts Maps Measures Mechanics Medical Medical center Medicine Meniscus structure of joint Mentors Mesenchymal Stem Cells Methods Mission Modeling Molecular Analysis Musculoskeletal Musculoskeletal Diseases Natural regeneration Nature Nuclear Orthopedic Surgery Orthopedics Pain Paper Pennsylvania Phenotype Philadelphia Population Porosity Privatization Prize Production Property Publications Publishing Regenerative Medicine Rehabilitation therapy Reporting Research Research Personnel Science Scientist Series Services Signal Transduction Societies Speed Structure Structure-Activity Relationship Surgeon System Technology Time Tissue Engineering Tissues Translating Translational Research Translations United States Department of Veterans Affairs United States National Institutes of Health Universities Vertebral column Veterans Work adult stem cell analog articular cartilage biophysical properties career cartilage repair clinical application college editorial fabrication follow-up functional restoration healing implantation improved improved outcome in vivo interest intervertebral disk degeneration joint function mechanical behavior mechanical load member military veteran musculoskeletal injury nanofiber next generation novel nucleus pulposus patient population pre-clinical professor programs regenerative regenerative therapy repaired scaffold stem cell function stem cells technology development tissue regeneration tool translational medicine

项目摘要

Abstract Robert L. Mauck, PhD is a Research Health Scientist and Co-Director of the Translational Musculoskeletal Research Center at the Corporal Michael J. Crescenz VA Medical Center in Philadelphia. He is also the Mary Black Ralston Professor of Education and Research in Orthopaedic Surgery and Professor of Bioengineering at the University of Pennsylvania, and the Director of the McKay Orthopaedic Research Laboratory. At Penn, Dr. Mauck also serves as the Co-Director of the Program in Musculoskeletal Regeneration in the Institute for Regenerative Medicine (IRM), is the Director of the Biomechanics Core of the Penn Center for Musculoskeletal Disorders (PCMD), and is a founding member of the Center for Engineering Mechanobiology (CEMB). Dr. Mauck’s research program is focused on the engineering and mechanobiology of musculoskeletal tissues, with a particular interest in restoring articular cartilage, the knee meniscus, and the intervertebral disc. Dr. Mauck’s team uses mechanical and molecular analyses to explore native tissue structure function relationships, and employs this information to enhance the functional properties of engineered constructs through focused technology development. His work explores progenitor cell function and efficacy in a variety of biomaterial contexts and across multiple length scales, from subcellular biophysical properties to translation of engineered constructs in large animal models and humans. The goal of his research program is to develop and deploy novel regenerative therapies to improve musculoskeletal health in Veterans and the population as a whole. Dr. Mauck is supported by the Department of Veterans Affairs, the National Institutes of Health, the National Science Foundation, and several foundations and private organizations. He is an active member of the American Society for Mechanical Engineers (ASME), the Orthopaedic Research Society (ORS), the Tissue Engineering and Regenerative Medicine International Society (TERMIS), the Biomedical Engineering Society (BMES), and the International Cartilage Repair Society (ICRS). Dr. Mauck is the co-Editor-in-Chief of the Journal of Orthopaedic Research Spine and serves on the editorial board of the Journal of Orthopaedic Research, the Journal of the Mechanical Behavior of Biomedical Materials, and the Journal of Experimental Orthopaedics. He has published >190 manuscripts (cited >10400 times), >300 abstracts, and >12 book chapters. Dr. Mauck has been recognized for his contributions to the field with the ISSLS Prize in Biomechanics (2008), the YC Fung Young Investigator Award from the ASME (2009), the BMES-CMBE ‘Rising Star’ Award (2011), the Penn Medicine Montague Research Prize (2013), election to the College of Fellows of the American Institute for Medical and Biological Engineering (2014), the Kappa Delta Young Investigator Award from the American Academy of Orthopaedic Surgeons (2015), the Berton Rahn Research Award from the AO Foundation (2017), and was inducted as a Fellow of International Orthopaedic Research (FIOR) of the International Combined Orthopaedic Research Societies (ICORS) College of Fellows (2019). He was also recently selected as the ‘Research Scientist of the Year’ at the CMC VAMC (2019).

抽象的 Robert L. Mauck 博士是一位研究健康科学家，也是转化研究中心的联合主任迈克尔·J·克雷森兹下士退伍军人医疗中心肌肉骨骼研究中心他还是费城骨科教育和研究玛丽·布莱克·罗尔斯顿教授。宾夕法尼亚大学外科和生物工程教授，兼该中心主任莫克博士还担任宾夕法尼亚大学麦凯骨科研究实验室的联合主任。再生医学研究所 (IRM) 的肌肉骨骼再生项目是宾夕法尼亚大学肌肉骨骼疾病中心 (PCMD) 生物力学核心主任，工程力学生物学中心（CEMB）的创始成员。 Mauck 博士的研究项目专注于肌肉骨骼的工程和机械生物学组织，特别关注恢复关节软骨、膝半月板和膝关节 Mauck 博士的团队利用机械和分子分析来探索天然椎间盘。组织结构功能关系，并利用这些信息来增强功能他的工作通过重点技术开发来探索工程结构的特性。祖细胞在各种生物材料环境和多个长度中的功能和功效从亚细胞生物物理特性到大型动物工程构建体的转化他的研究计划的目标是开发和部署新型再生技术。改善退伍军人和整个人群肌肉骨骼健康的疗法。莫克博士得到了退伍军人事务部、美国国立卫生研究院、他是国家科学基金会以及多个基金会和私人组织的活跃分子。美国机械工程师学会（ASME）、骨科研究会会员学会 (ORS)、国际组织工程与再生医学学会 (TERMIS)、生物医学工程学会 (BMES) 和国际软骨修复学会 (ICRS)。 Mauck 博士是《Journal of Orthopaedic Research Spine》的联合主编，并在《Journal of Orthopaedic Research》、《Journal of the Mechanical Behaviour》编委他在《生物医学材料》和《实验骨科杂志》上发表了超过 190 篇文章。手稿（被引用 >10400 次）、>300 篇摘要和 >12 个书籍章节。 Mauck 博士因其对该领域的贡献而荣获 ISSLS 生物力学奖（2008年），ASME颁发的YC Fung青年研究员奖（2009年），BMES-CMBE“新星” 奖（2011 年）、宾夕法尼亚大学医学院蒙塔古研究奖（2013 年）、当选为医学院美国医学和生物工程研究所研究员 (2014)，Kappa Delta 美国骨科医师学会青年研究员奖（2015 年），Berton 荣获 AO 基金会 Rahn 研究奖（2017 年），并被任命为国际院士国际联合骨科研究会的骨科研究（FIOR）（ICORS）研究员学院（2019），他最近还被选为“研究科学家”。 CMC VAMC 年”（2019 年）。