RR&D Research Career Scientist Award Application

基本信息

批准号：
10533303
负责人：
Robert L Mauck
金额：
--
依托单位：
PHILADELPHIA VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10533303
关键词：
Academy Acceleration Address American Anatomy Animal Model Area Award Biocompatible Materials Biological Biomechanics Biomedical Engineering Biomimetics Biophysics Black race Book Chapters Cartilage Cell Nucleus Cell Therapy Cells Cellular Infiltration Chondrogenesis Coculture Techniques Communication Custom Degenerative polyarthritis Dense Connective Tissue Development Doctor of Philosophy Drug Delivery Systems Education Elements Engineering Environment Epitopes Extracellular Matrix Foundations Gait General Population Goals Goat Growth Health Human Hydrogels In Vitro Incidence International Intervertebral disc structure Joints Journals K-Series Research Career Programs Knee Laboratory Research Length Manuscripts Maps Measures Mechanics Medical Medical center Medicine Meniscus structure of joint Mentors Mesenchymal Stem Cells Methods Mission Modeling Molecular Analysis Musculoskeletal Musculoskeletal Diseases Natural regeneration Nature Nuclear Orthopedic Surgery Orthopedics Pain Paper Pennsylvania Phenotype Philadelphia Population Porosity Privatization Prize Production Property Publications Publishing Regenerative Medicine Rehabilitation therapy Reporting Research Research Personnel Science Scientist Series Services Signal Transduction Societies Speed Structure Structure-Activity Relationship Surgeon System Technology Time Tissue Engineering Tissues Translating Translational Research Translations United States Department of Veterans Affairs United States National Institutes of Health Universities Vertebral column Veterans Work adult stem cell analog articular cartilage biophysical properties career cartilage repair clinical application college editorial fabrication follow-up functional restoration healing implantation improved improved outcome in vivo interest intervertebral disk degeneration joint function mechanical behavior mechanical load member military veteran musculoskeletal injury nanofiber next generation novel nucleus pulposus patient population pre-clinical professor programs regenerative regenerative therapy repaired scaffold stem cell function stem cells technology development tissue regeneration tool translational medicine

项目摘要

Abstract Robert L. Mauck, PhD is a Research Health Scientist and Co-Director of the Translational Musculoskeletal Research Center at the Corporal Michael J. Crescenz VA Medical Center in Philadelphia. He is also the Mary Black Ralston Professor of Education and Research in Orthopaedic Surgery and Professor of Bioengineering at the University of Pennsylvania, and the Director of the McKay Orthopaedic Research Laboratory. At Penn, Dr. Mauck also serves as the Co-Director of the Program in Musculoskeletal Regeneration in the Institute for Regenerative Medicine (IRM), is the Director of the Biomechanics Core of the Penn Center for Musculoskeletal Disorders (PCMD), and is a founding member of the Center for Engineering Mechanobiology (CEMB). Dr. Mauck’s research program is focused on the engineering and mechanobiology of musculoskeletal tissues, with a particular interest in restoring articular cartilage, the knee meniscus, and the intervertebral disc. Dr. Mauck’s team uses mechanical and molecular analyses to explore native tissue structure function relationships, and employs this information to enhance the functional properties of engineered constructs through focused technology development. His work explores progenitor cell function and efficacy in a variety of biomaterial contexts and across multiple length scales, from subcellular biophysical properties to translation of engineered constructs in large animal models and humans. The goal of his research program is to develop and deploy novel regenerative therapies to improve musculoskeletal health in Veterans and the population as a whole. Dr. Mauck is supported by the Department of Veterans Affairs, the National Institutes of Health, the National Science Foundation, and several foundations and private organizations. He is an active member of the American Society for Mechanical Engineers (ASME), the Orthopaedic Research Society (ORS), the Tissue Engineering and Regenerative Medicine International Society (TERMIS), the Biomedical Engineering Society (BMES), and the International Cartilage Repair Society (ICRS). Dr. Mauck is the co-Editor-in-Chief of the Journal of Orthopaedic Research Spine and serves on the editorial board of the Journal of Orthopaedic Research, the Journal of the Mechanical Behavior of Biomedical Materials, and the Journal of Experimental Orthopaedics. He has published >190 manuscripts (cited >10400 times), >300 abstracts, and >12 book chapters. Dr. Mauck has been recognized for his contributions to the field with the ISSLS Prize in Biomechanics (2008), the YC Fung Young Investigator Award from the ASME (2009), the BMES-CMBE ‘Rising Star’ Award (2011), the Penn Medicine Montague Research Prize (2013), election to the College of Fellows of the American Institute for Medical and Biological Engineering (2014), the Kappa Delta Young Investigator Award from the American Academy of Orthopaedic Surgeons (2015), the Berton Rahn Research Award from the AO Foundation (2017), and was inducted as a Fellow of International Orthopaedic Research (FIOR) of the International Combined Orthopaedic Research Societies (ICORS) College of Fellows (2019). He was also recently selected as the ‘Research Scientist of the Year’ at the CMC VAMC (2019).

抽象的 Robert L. Mauck，博士是研究健康科学家兼转化的联合导演下士Michael J. Crescenz VA医疗中心的肌肉骨骼研究中心费城。他还是骨科教育与研究教授玛丽·布莱克·拉尔斯顿（Mary Black Ralston）宾夕法尼亚大学的外科和生物工程教授，以及麦凯骨科研究实验室。在宾夕法尼亚州，马克博士还担任再生医学研究所（IRM）的肌肉骨骼再生计划是宾夕法尼亚州肌肉骨骼疾病中心（PCMD）的生物力学核心主任，IS 工程机械生物学中心（CEMB）的创始成员。 Mauck博士的研究计划的重点是肌肉骨骼的工程和机械生物学组织，特别有兴趣恢复关节软骨，膝盖弯面条和椎间盘。 Mauck博士的团队使用机械和分子分析来探索本地组织结构功能关系，员工这些信息以增强功能通过重点技术开发的工程结构的属性。他的工作探索祖细胞功能和多种生物材料的效率以及多长度从亚细胞生物物理特性到大型动物工程构建体的翻译量表模特和人类。他的研究计划的目的是开发和部署新颖的再生改善退伍军人和整个人口的肌肉骨骼健康的疗法。马克博士得到退伍军人事务部，国立卫生研究院，国家科学基金会以及几个基金会和私人组织。他是一个活跃的美国机械工程师学会（ASME）的成员，骨科研究社会（ORS），组织工程和再生医学国际学会（TERMIS），生物医学工程学会（BME）和国际软骨维修学会（ICRS）。 Mauck博士是《骨科研究杂志》杂志的主编，并在《骨科研究杂志》编辑委员会，《机械行为的杂志》生物医学材料和实验骨科杂志。他已经出版了> 190 手稿（引用> 10400次），> 300个摘要和> 12章章节。 Mauck博士因其对ISSLS生物力学奖的贡献而获得认可（2008年），ASME（2009年）的YC Fung Young研究者奖，BMES-CMBE“后起之秀” 奖（2011年），宾夕法尼亚州蒙塔古研究奖（2013年），选举美国医学与生物工程研究所（2014），卡帕三角洲的研究所美国骨科医生学院的年轻研究员奖（2015年），贝尔顿 AO基金会（2017年）的Rahn Research Award，被选为国际会员国际骨科研究社会的骨科研究（FIOR）（ICORS）研究员学院（2019年）。他最近还被选为“ 在CMC VAMC（2019）的年。