RR&D Research Career Scientist Award Application

RR

• 批准号: 10311108
• 负责人: Robert L Mauck
• 金额: --
• 依托单位: PHILADELPHIA VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311108
• 关键词: Academy; Address; American; Anatomy; Animal Model; Area; Award; Biocompatible Materials; Biological; Biomechanics; Biomedical Engineering; Biomimetics; Biophysics; Black race; Book Chapters; Cartilage; Cell Nucleus; Cell Therapy; Cells; Cellular Infiltration; Chondrogenesis; Coculture Techniques; Communication; Custom; Degenerative polyarthritis; Dense Connective Tissue; Development; Doctor of Philosophy; Drug Delivery Systems; Elements; Engineering; Environment; Epitopes; Extracellular Matrix; Foundations; Gait; General Population; Goals; Goat; Growth; Health; Human; Hydrogels; In Vitro; Incidence; Institutes; International; Intervertebral disc structure; Joints; Journals; K-Series Research Career Programs; Knee; Laboratory Research; Length; Manuscripts; Maps; Measures; Mechanics; Medical; Medical center; Medicine; Meniscus structure of joint; Mentors; Mesenchymal Stem Cells; Methods; Mission; Modeling; Molecular Analysis; Musculoskeletal; Musculoskeletal Diseases; Natural regeneration; Nature; Nuclear; Orthopedic Surgery; Orthopedics; Pain; Paper; Pennsylvania; Phenotype; Philadelphia; Population; Porosity; Privatization; Prize; Production; Property; Publications; Publishing; Regenerative Medicine; Rehabilitation therapy; Reporting; Research; Research Personnel; Science; Scientist; Series; Services; Signal Transduction; Societies; Speed; Structure; Structure-Activity Relationship; Surgeon; System; Technology; Time; Tissue Engineering; Tissues; Translating; Translational Research; Translations; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Vertebral column; Veterans; Work; adult stem cell; analog; articular cartilage; base; biophysical properties; career; cartilage repair; clinical application; college; editorial; education research; follow-up; functional restoration; healing; hydrogel scaffold; implantation; improved; improved outcome; in vivo; interest; intervertebral disk degeneration; joint function; mechanical behavior; mechanical load; member; military veteran; musculoskeletal injury; nanofiber; next generation; novel; nucleus pulposus; patient population; pre-clinical; professor; programs; regenerative; regenerative therapy; repaired; scaffold; stem cell function; stem cells; technology development; tissue regeneration; tool; translational medicine

Abstract Robert L. Mauck, PhD is a Research Health Scientist and Co-Director of the Translational Musculoskeletal Research Center at the Corporal Michael J. Crescenz VA Medical Center in Philadelphia. He is also the Mary Black Ralston Professor of Education and Research in Orthopaedic Surgery and Professor of Bioengineering at the University of Pennsylvania, and the Director of the McKay Orthopaedic Research Laboratory. At Penn, Dr. Mauck also serves as the Co-Director of the Program in Musculoskeletal Regeneration in the Institute for Regenerative Medicine (IRM), is the Director of the Biomechanics Core of the Penn Center for Musculoskeletal Disorders (PCMD), and is a founding member of the Center for Engineering Mechanobiology (CEMB). Dr. Mauck’s research program is focused on the engineering and mechanobiology of musculoskeletal tissues, with a particular interest in restoring articular cartilage, the knee meniscus, and the intervertebral disc. Dr. Mauck’s team uses mechanical and molecular analyses to explore native tissue structure function relationships, and employs this information to enhance the functional properties of engineered constructs through focused technology development. His work explores progenitor cell function and efficacy in a variety of biomaterial contexts and across multiple length scales, from subcellular biophysical properties to translation of engineered constructs in large animal models and humans. The goal of his research program is to develop and deploy novel regenerative therapies to improve musculoskeletal health in Veterans and the population as a whole. Dr. Mauck is supported by the Department of Veterans Affairs, the National Institutes of Health, the National Science Foundation, and several foundations and private organizations. He is an active member of the American Society for Mechanical Engineers (ASME), the Orthopaedic Research Society (ORS), the Tissue Engineering and Regenerative Medicine International Society (TERMIS), the Biomedical Engineering Society (BMES), and the International Cartilage Repair Society (ICRS). Dr. Mauck is the co-Editor-in-Chief of the Journal of Orthopaedic Research Spine and serves on the editorial board of the Journal of Orthopaedic Research, the Journal of the Mechanical Behavior of Biomedical Materials, and the Journal of Experimental Orthopaedics. He has published >190 manuscripts (cited >10400 times), >300 abstracts, and >12 book chapters. Dr. Mauck has been recognized for his contributions to the field with the ISSLS Prize in Biomechanics (2008), the YC Fung Young Investigator Award from the ASME (2009), the BMES-CMBE ‘Rising Star’ Award (2011), the Penn Medicine Montague Research Prize (2013), election to the College of Fellows of the American Institute for Medical and Biological Engineering (2014), the Kappa Delta Young Investigator Award from the American Academy of Orthopaedic Surgeons (2015), the Berton Rahn Research Award from the AO Foundation (2017), and was inducted as a Fellow of International Orthopaedic Research (FIOR) of the International Combined Orthopaedic Research Societies (ICORS) College of Fellows (2019). He was also recently selected as the ‘Research Scientist of the Year’ at the CMC VAMC (2019).

抽象的 Robert L. Mauck，博士是研究健康科学家兼转化的联合导演 下士Michael J. Crescenz VA医疗中心的肌肉骨骼研究中心 费城。他还是骨科教育与研究教授玛丽·布莱克·拉尔斯顿（Mary Black Ralston） 宾夕法尼亚大学的外科和生物工程教授，以及 麦凯骨科研究实验室。在宾夕法尼亚州，马克博士还担任 再生医学研究所（IRM）的肌肉骨骼再生计划是 宾夕法尼亚州肌肉骨骼疾病中心（PCMD）的生物力学核心主任，IS 工程机械生物学中心（CEMB）的创始成员。 Mauck博士的研究计划的重点是肌肉骨骼的工程和机械生物学 组织，特别有兴趣恢复关节软骨，膝盖弯面条和 椎间盘。 Mauck博士的团队使用机械和分子分析来探索本地 组织结构功能关系，员工这些信息以增强功能 通过重点技术开发的工程结构的属性。他的工作探索 祖细胞功能和多种生物材料的效率以及多长度 从亚细胞生物物理特性到大型动物工程构建体的翻译量表 模特和人类。他的研究计划的目的是开发和部署新颖的再生 改善退伍军人和整个人口的肌肉骨骼健康的疗法。 马克博士得到退伍军人事务部，国立卫生研究院， 国家科学基金会以及几个基金会和私人组织。他是一个活跃的 美国机械工程师学会（ASME）的成员，骨科研究 社会（ORS），组织工程和再生医学国际学会（TERMIS）， 生物医学工程学会（BME）和国际软骨维修学会（ICRS）。 Mauck博士是《骨科研究杂志》杂志的主编，并在 《骨科研究杂志》编辑委员会，《机械行为的杂志》 生物医学材料和实验骨科杂志。他已经出版了> 190 手稿（引用> 10400次），> 300个摘要和> 12章章节。 Mauck博士因其对ISSLS生物力学奖的贡献而获得认可 （2008年），ASME（2009年）的YC Fung Young研究者奖，BMES-CMBE“后起之秀” 奖（2011年），宾夕法尼亚州蒙塔古研究奖（2013年），选举 美国医学与生物工程研究所（2014），卡帕三角洲的研究所 美国骨科医生学院的年轻研究员奖（2015年），贝尔顿 AO基金会（2017年）的Rahn Research Award，被选为国际会员 国际骨科研究社会的骨科研究（FIOR） （ICORS）研究员学院（2019年）。他最近还被选为“ 在CMC VAMC（2019）的年。