CSHL 2022 Mechanisms & Models of Cancer Conference

CSHL 2022 机制

基本信息

批准号：
10536252
负责人：
DAVID J. STEWART
金额：
$ 0.75万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10536252
关键词：
Address Antibodies Area Biochemical Biological Biological Models Cancer Biology Cancer Center Cancer Model Cancer Patient Cell Lineage Cellular biology Clinical Computational Biology Data Development Disease Drug Combinations Ensure Environment Epigenetic Process Equilibrium Evolution Faculty Female Fostering Future Genomics Goals Immune response Immunologics Immunotherapy In Vitro Individual Institutes International Investigational Therapies Laboratories Laboratory Scientists Lead Length of Stay Malignant Neoplasms Metabolic Minority Modeling Molecular Molecular Genetics Monitor Neoplasm Metastasis Oncogenic Oral Organoids Participant Patients Persons Postdoctoral Fellow Process Published Comment Quality of life Refractory Research Research Institute Research Personnel Resistance Schedule Scientist Series Signal Transduction Signs and Symptoms Switzerland Technology Testing Therapeutic Training Tumor Suppressor Genes United Kingdom Update Woman Work anticancer research base cancer cell cancer genetics cancer genome cancer heterogeneity cancer prevention cancer survival cancer therapy cancer type career data exchange epigenome functional genomics graduate student improved in vivo innovation insight interest laboratory facility lectures meetings member next generation notch protein novel therapeutic intervention novel therapeutics posters prospective protein complex response side effect small molecule inhibitor stem cells structural biology success symposium targeted cancer therapy targeted treatment three dimensional structure tumor tumor heterogeneity tumor immunology tumor metabolism tumor microenvironment tumor progression unpublished works

项目摘要

COLD SPRING HARBOR LABORATORY CONFERENCE MECHANISMS AND MODELS OF CANCER August 16 - 20, 2022 Recent years have produced transformative discoveries that have revealed the mechanisms behind the development and progression of cancer, both from the perspective of the cancer cell and the host response. These advances have resulted in targeted cancer therapies that have extended patient survival, as well as new immune-based therapies that have, in select cases, resulted in cures of previously intractable malignancies. Stunning technological developments have enabled us to interrogate the cancer genome and epigenome with unprecedented depth and sophistication, uncovering the challenges that tumor heterogeneity imposes for cancer therapy, while also enabling more accurate therapeutic monitoring. Advances in functional genomic technologies allow us to turn oncogenes and tumor suppressor genes on an off at will in vitro and in vivo to determine their function. More robust tumor models, such as organoids, have been developed, revealing new insights into cancer cell biology, while enabling the rapid identification and testing of new therapeutics. With advances in structural biology, we can examine the three-dimensional structure of oncogenic proteins and protein complexes, facilitating development of small molecule inhibitors or antagonistic antibodies. Powerful strategies also allow us to interrogate how metabolic reprogramming in cancer cells, opening up the possibility of novel therapeutic approaches that exploit metabolic vulnerabilities. Improvements in computational biology are yielding new insights into biological networks and tumor evolution. Dissemination and use of these technologies, models and mechanism-based approaches in this fast-moving field is greatly facilitated by meetings that bring investigators together to present and openly discuss their latest unpublished research findings. We also need to train the next generation of leaders in the field, and an essential part of this process is this fantastic opportunity for young investigators, such as graduate students and postdocs, to present their work and interact one-on-one with senior investigators. The Mechanisms and Models of Cancer meeting at Cold Spring Harbor Laboratory (CSHL) is one of the premier vehicles for promoting the next intellectual leaps in cancer research and propelling the field into the future to the benefit of cancer patients. The precise scope of the individual sessions will be decided on the basis of the openly submitted abstracts. Each session will be chaired by two established scientists in the field, who will establish the format of each session based on submitted abstracts. The chairs will introduce and give an overview of the topics in their sessions and a brief update on their own research. Particular emphasis will be given to promoting the active participation of graduate students, postdoctoral fellows and new investigators, as well as of leading scientists in the field. Two leading experts in diverse areas of cancer biology will deliver keynote addresses during the conference, and there will also be a “legacy lecture” by a major luminary in the field. It is anticipated that the meeting will provide unique opportunities for the exchange of data and ideas by both junior and senior investigators in different areas of research as they apply to cancer genetics and tumor suppressor genes. Given the success of past meetings held at CSHL on this topic between 1996 and 2020, we anticipate the attendance of about 400 scientists from laboratories around the world.

冷泉港实验室会议癌症的机制和模型 8月16日至2022年近年来产生了变革性发现，揭示了背后的机制从癌细胞的角度和宿主的角度来看，癌症的发展和进展回复。这些进展导致了靶向癌症疗法，这些疗法扩大了患者的生存，以及新的基于免疫的疗法，在某些情况下，可以治愈以前的治疗方法棘手的恶性肿瘤。令人惊叹的技术发展使我们能够询问癌症具有前所未有的深度和精致的基因组和表观基因组，揭示了挑战癌症治疗可能不可能，同时还可以更准确地治疗监测。功能性基因组技术的进步使我们能够将肿瘤基因和肿瘤抑制基因转换为随意在体外和体内确定其功能。更健壮的肿瘤模型，例如类器官，已经开发出来，揭示了对癌细胞生物学的新见解，同时可以快速识别和新疗法的测试。随着结构生物学的进步，我们可以检查三维致癌蛋白和蛋白质复合物的结构，支持小分子抑制剂的发展或拮抗抗体。强大的策略还使我们能够询问代谢重新编程癌细胞，开辟了开发新型治疗方法的可能性漏洞。计算生物学的改善正在对生物网络产生新的见解，肿瘤的演变。这些技术，基于模型和机制的方法的传播和使用在这个快速发展的领域中，会议会大大准备，这些会议使调查人员聚集在一起，并公开讨论他们最新的未发表的研究结果。我们还需要训练下一代该领域的领导者，这一过程的重要组成部分是年轻调查员的绝佳机会，例如研究生和博士后，介绍他们的作品并与高级的一对一互动调查人员。冷春港实验室（CSHL）的癌症会议的机制和模型是促进癌症研究的下一个知识分子的主要车辆之一，并推动涉及癌症患者受益的未来。单个会议的确切范围将是根据公开提交的摘要决定。每个会议将由两个成立的主持人主持该领域的科学家将根据提交的摘要建立每个会话的格式。椅子将介绍并概述他们的会议中的主题，并简要更新研究。特别重点将促进研究生的积极参与，博士后研究员和新调查人员以及该领域的主要科学家。两位主要专家在癌症的潜水区域，生物学将在会议期间提供主题演讲，还将成为该领域的主要灯具的“传统演讲”。预计会议将提供独特的在不同领域的初级和高级调查员交换数据和想法的机会研究它们适用于癌症遗传学和肿瘤抑制基因。鉴于过去的成功在1996年至2020年之间在CSHL举行的有关此主题的会议，我们预计大约有400 来自世界各地实验室的科学家。