Administrative Core

行政核心

• 批准号: 10650142
• 负责人: JANOS ZEMPLENI
• 金额: $ 72.28万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650142
• 关键词: Address; Advisory Committees; Agriculture; American Heart Association; Award; Basic Science; Bioinformatics; Biological; Biomedical Research; Biometry; Center for Translational Science Activities; Centers of Research Excellence; Clinical; Clinical Research; Collaborations; Data Analyses; Development; Development Plans; Disease; Ensure; Equipment; Europe; Evaluation; Event; Experimental Designs; Faculty; Fostering; Foundations; Funding; Goals; Grant; Health; Incentives; Individual; Infrastructure; Institution; Interdisciplinary Study; Leadership; Medical center; Mentors; Metabolic; National Institute of Diabetes and Digestive and Kidney Diseases; Nebraska; Nutritional Study; Obesity; Obesity Epidemic; Obesity associated disease; Peer Review; Phase; Play; Positioning Attribute; Productivity; Publications; Publishing; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Secure; Services; Signal Transduction; Strategic Planning; Supercomputing; Translational Research; Travel; United States; United States National Institutes of Health; Universities; Vision; Visit; cohort; combat; community based participatory research; computerized data processing; data acquisition; dietary; equipment acquisition; foodborne; improved; member; multidisciplinary; nutrition; nutritional genomics; obesity prevention; prevent; professor; programs; recruit; square foot; statistics; success

The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) at the University of Nebraska supports research on the identification of biological, mainly food-borne, signals that prevent, treat, and cure obesity and obesity-related diseases. NPOD, a Center of Biomedical Research Excellence (COBRE), is guided by the overarching goals to strengthen the metabolic, obesity, and nutrition research infrastructure in Nebraska and enhance the ability of NPOD investigators to compete for external research funding – all while making significant research contributions to combatting the national obesity epidemic. Critical to NPOD's ability to operate effectively and efficiently is a strong Administrative Core that provides the programmatic leadership, administrative support, and infrastructure necessary to ensure the center is successful. Importantly, the Administrative Core will maintain continuity in its leadership and the membership of its external and internal advisory committees during COBRE Phase 2. During Phase 1, the Administrative Core played an instrumental role in NPOD success as evidenced by several key metrics. NPOD junior investigators published 154 peer- reviewed publications and secured approximately $31M in research dollars, including 11 major research grants from NIH (three R01, one R21, one R35), the U.S. Department of Agriculture (three), the American Heart Association (two), and the Bill and Melinda Gates Foundation. Center membership grew to 51 multidisciplinary investigators in 16 units with over $96M in external research funding. The Administrative Core secured additional space and equipment for NPOD's Research Core and will play a key role in the center's Phase 2 success by leveraging NIH funding and institutional commitments for five new faculty positions in four departments (plus a UNL Program of Excellence hire in nutrigenomics), approximately $1.2M toward start-up packages, and over $1M in cash matches in support of pilot, seed, and revision grant programs, mentor incentives, and equipment purchases. The Administrative Core will leverage these commitments and Phase 1 successes to 1) increase the critical mass of center investigators conducting multidisciplinary research through new hires, pilot and seed grants, and facilitate the submission of large-scale proposals through providing P01 (or RM1) pilot grant funding; 2) facilitate the transition of junior investigators to independent investigator status by providing honoraria for external and internal mentors, support for individual development plans with milestones, formative and summative evaluations, and networking opportunities via travel support and a visiting professors program; 3) support the success of the Biomedical and Obesity Research Core by coordinating services in experimental design, large data processing, and biostatistics and bioinformatics analyses and facilitating the acquisition of equipment with institutional commitments for five new equipment additions planned in Phase 2; and 4) broaden the scope of center research to include clinical and translational research by recruiting a new hire and considering nine in a pipeline of 21 candidates for project leader slots who have a focus on clinical and translational research.

内布拉斯加州预防肥胖症中心通过饮食分子（NPOD） 内布拉斯加州支持有关鉴定生物学（主要是食物传播）的研究，这些信号是预防，治疗，治疗， 并治愈肥胖和与肥胖有关的疾病。 NPOD，生物医学研究卓越中心（COBRE）， 以加强代谢，肥胖和营养研究基础设施的总体目标为指导 内布拉斯加州并增强了NPOD调查人员争夺外部研究资金的能力 - 为打击国家肥胖流行做出了重要的研究贡献。对NPOD的能力至关重要 有效，有效地运作是一个强大的行政核心，可提供程序化领导， 行政支持以及确保中心成功所需的基础架构。重要的是， 行政核心将保持其领导和外部和内部成员的连续性 在第2阶段的咨询委员会。在第1阶段，行政核心发挥了乐器 几个关键指标证明了NPOD成功中的作用。 NPOD初级调查人员发表了154名同行 审查出版物并获得了大约3100万美元的研究美元，其中包括11项主要研究补助金 美国农业部（三）（三个R01，1 R21，1 R35），美国心脏 协会（两个），比尔和梅琳达·盖茨基金会。中心会员人数增长到51个多学科 16个单位的调查人员拥有超过9600万美元的外部研究资金。行政核心确保了额外 NPOD研究核心的空间和设备，将在中心的第二阶段成功中发挥关键作用 利用NIH的资金和机构承诺在四个部门的五个新教师职位（加上一个 UNL卓越计划雇用营养素学），大约120万美元用于启动套餐，以及以上 100万美元的现金竞赛，以支持飞行员，种子和修订赠款计划，心理激励措施和设备 购买。行政核心将利用这些承诺，并将第一阶段的成功提高到1）增加 通过新员工，飞行员和种子进行多学科研究的中心研究人员的关键质量 通过提供P01（或RM1）试点赠款资金，赠款，并促进提交大规模建议； 2）通过为酬金提供酬金 外部和内部导师，以里程碑，形成性和 通过旅行支持和访问教授计划进行的总结评估和网络机会； 3） 通过协调服务在实验中支持生物医学和肥胖研究核心的成功 设计，大数据处理以及生物统计学和生物信息学分析并支持获得 在第2阶段计划的五个新设备增加的设备承诺； 4）扩大 中心研究的范围包括招募新员工并考虑 有9个在21名候选人的管道中，他们专注于临床和翻译研究。