Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

内布拉斯加州通过膳食分子预防肥胖病中心

• 批准号: 8904674
• 负责人: JANOS ZEMPLENI
• 金额: $ 220.19万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8904674
• 关键词: Address; American; Area; Biochemistry; Bioinformatics; Biological; Biostatistics Core; Cardiovascular Diseases; Centers of Research Excellence; Charge; Clinical; Clinical Research; Core Facility; Development; Diabetes Mellitus; Diet; Disease; Environment; Epidemic; Epigenetic Process; Faculty; Funding; Goals; Grant; Health; Health Care Costs; Healthcare Systems; High Prevalence; Human; Immunology; Industry; Instruction; Intake; Interdisciplinary Study; Intervention; Investigation; Laboratories; Link; Liver diseases; Medical; Medical center; Mentors; Meta-Analysis; Molecular Biology; NIH Program Announcements; Nebraska; Nutrient; Obesity; Obesity associated disease; Outcome; Personal Satisfaction; Phase; Prevention; Prevention strategy; Program Development; Recommendation; Research; Research Personnel; Research Priority; Research Project Grants; Signal Pathway; Signal Transduction; Staging; Strategic Planning; Stress; Talents; Targeted Research; Techniques; Training; Translating; Translational Research; United States; Universities; Vision; base; clinical practice; combat; community setting; consumer behavior; cost; cost effective; data sharing; economic impact; food science; health economics; health organization; improved; innovation; meetings; multidisciplinary; non-alcoholic fatty liver; novel strategies; nutrition; obesity prevention; prevent; programs; research data dissemination; response; salt intake; saturated fat; success; tool development; user-friendly

The University of Nebraska-Lincoln, in partnership with the University of Nebraska Medical Center, proposes to establish the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) as a Center of Biomedical Research Excellence. NPOD will unite research strengths in nutrient signaling to develop junior faculty talent and utilize novel approaches in discovery-based research and translation to combat the growing epidemic of obesity-related disorders through consumer-friendly and cost-efficient intervention strategies, beginning with a focus on cardiovascular disease, diabetes, and non-alcoholic fatty liver disease. NPOD will create a nationally recognized center charged with developing and sustaining a critical mass of investigators dedicated to obesity research and leverage Center discoveries to devise and implement effective strategies for the prevention of obesity-related diseases through the dietary manipulation of nutrient signaling pathways. The Center's goals will be accomplished through three specific aims to: (1) establish an administrative core and programs to support and enhance NPOD research; (2) develop a critical mass of faculty through the support of five thematically linked primary research projects, a vigorous mentoring program for Project Leaders, a pilot grant program, a Molecular Biology, Bioinformatics and Biostatistics Core facility, and a research tool development program in the Core; and (3) increase research capacity through targeted recruitment of researchers in areas key to Center success. NPOD's world-class, multidisciplinary research environment will be instrumental in supporting the development of strategies to prevent cardiovascular disease, diabetes, and non-alcoholic fatty liver disease; creating a skilled workforce in a national priority area; implementing techniques for translating discoveries in the laboratory to inform clinical practice and influence consumer behavior; and utilizing innovative approaches to instant sharing of research data and dissemination of recommendations for consumers. NPOD investigators bring the breadth of expertise necessary to accomplish the Center's grand vision and share the common tenant that obesity-related diseases can be prevented through the manipulation of nutrient signaling pathways and that this prevention strategy is attractive and accessible to consumers, thus holding great potential for long-term national impact.

内布拉斯加州林肯大学与内布拉斯加州大学医学中心合作 建议通过饮食建立内布拉斯加州预防肥胖症的中心 分子（NPOD）是卓越生物医学研究中心。 NPOD将团结研究优势 在营养信号中发展初级教师人才并利用基于发现的新方法 研究和翻译以通过消费者友好型肥胖相关疾病的流行而与日益增长的流行病作斗争 和经济高效的干预策略，首先要关注心血管疾病， 糖尿病和非酒精性脂肪肝病。 NPOD将创建一个全国认可的中心 通过发展并维持大量研究人员，致力于肥胖研究和 利用中心发现，以制定和实施有效的策略来预防与肥胖有关的 通过营养信号通路的饮食操纵疾病。中心的目标将 通过以下三个特定目标来完成：（1）建立一个行政核心和计划 支持并增强NPOD研究； （2）通过五个 主题链接的主要研究项目，一个针对项目负责人的剧烈指导计划，飞行员 赠款计划，一种分子生物学，生物信息学和生物统计学核心设施，以及研究工具 核心发展计划； （3）通过有针对性的招募来提高研究能力 领域的研究人员关键要取得成功。 NPOD的世界一流的多学科研究环境 将有助于支持预防心血管疾病的策略的制定， 糖尿病和非酒精性脂肪肝病；在国家优先领域创建熟练的劳动力； 实施用于翻译实验室发现的技术，以告知临床实践和 影响消费者的行为；并利用创新方法即时共享研究数据和 传播给消费者的建议。 NPOD调查人员带来了广度的专业知识 完成中心的宏伟愿景并分享与肥胖有关的共同租户所必需的必要 可以通过操纵营养信号通路来防止疾病 预防策略是吸引人的，因此消费者可以使用，因此长期具有巨大的潜力 国家影响力。